Radioimmunoassay of serum SP 1 and HPL in normal and abnormal pregnancies

Abstract

Serum concentrations of the pregnancy-specific beta 1-glycoprotein (SP 1) and human placental lactogen (HPL) were measured by radioimmunoassay in 372 blood samples obtained from 40 women in the second half of a normal singleton pregnancy. The mean level of SP 1 steadily increased from 40 micrograms/ml in the 22nd week of pregnancy to 168 micrograms/ml in the 36th week of gestation and thereafter reached a plateau. The half-life of SP 1 during the first week after delivery was about 39 h. The clinical value of SP 1 in comparison to HPL estimations was assessed in a prospective study of a few high risk pregnancies. There were no significant differences between serum SP 1 and HPL levels in pregnancies complicated by preeclampsia with or without intrauterine growth retardation and in twin pregnancies. Serum HPL and SP 1 levels were equally effective in predicting placental insufficiency with fetal growth retardation.

Pregnancy‐Specific β1Glycoprotein, SP1 in Maternal Serum During Uncomplicated Single Pregnancies

“…Such a study was considered to give a more relevant reference material than when repeated samples were taken from a small number of women, especially if single observations are to be compared with the reference population. The SPI levels for the second half of pregnancy obtained in this study are comparable to those in a few other reports (27,33), though in most earlier reports higher values are given (10,39). These discrepancies are most likely explained by differences in the size and selection of the reference populations, the methods used for determination of SP,, including the choice of references, and the approach to statistical evaluations.…”

Glycan characterization of pregnancy-specific glycoprotein 1 and its identification as a novel Galectin-1 ligand

“…delivery (Pluta et al 1979. The circulating levels of Gal-1 in maternal serum are dysregulated in pregnancy complications and several studies indicate its potential use as marker for preeclampsia, miscarriage, and recurrent fetal loss (Hirashima et al 2017, Jeschke et al 2007, Schnabel et al 2016, Than et al 2008).…”

Pregnancy-specific glycoprotein 1 (PSG1) activates TGF-β and prevents dextran sodium sulfate (DSS)-induced colitis in mice

“…PSG1 is the most abundantly expressed of the 11 different PSG genes, which reach a median concentration of 168μg/ml at week 36 of pregnancy, when a plateau is reached 9 . PSGs belong to carcinoembryonic antigen (CEA) family but differ from other CEA family members in that they are secreted rather than membrane-bound.…”