Radiographic and Histologic Assessment of Calcium Sulfate in Experimental Animal Models and Clinical Use as a Resorbable Bone-Graft Substitute, a Bone-Graft Expander, and a Method for Local Antibiotic Delivery

Turner, Thomas M.; Urban, Robert M.; Gitelis, Steven; Kuo, Ken N.; Andersson, Gunnar

doi:10.2106/00004623-200100021-00003

Cited by 112 publications

(85 citation statements)

References 1 publication

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“…A preclinical canine study showed this material to be superior to CaSO 4 regarding the quantity and quality of bone formed in a contained humeral defect [30][31][32]. This material incorporates a matrix of CaSO 4 and dicalcium phosphate dihydrate (DCPD) into which b-tricalcium phosphate (b-TCP) granules are distributed [32].…”

Section: Introductionmentioning

confidence: 99%

Function After Injection of Benign Bone Lesions with a Bioceramic

Fillingham¹,

Lenart²,

Gitelis³

2012

Clinical Orthopaedics &Amp; Related Research

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Section: Introductionmentioning

confidence: 99%

Function After Injection of Benign Bone Lesions with a Bioceramic

Fillingham¹,

Lenart²,

Gitelis³

2012

Clinical Orthopaedics &Amp; Related Research

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“…2,5,[7][8][9][13][14][15][16]19 We evaluated the dissolution, elution, and biological activity of fastdegrading drug delivery vehicles made from cellulose binder and calcium sulfate dihydrate and from conventional calcium sulfate alpha-hemihydrate crushed into flakes. While this study used the Yarboro-type crushed conventional cast antibiotic-loaded calcium sulfate pellet as a comparison, the crushing/compressing of commercially available calcium sulfate pellets with tobramycin is not recommended by the manufacturer.…”

Section: Discussionmentioning

confidence: 99%

“…Calcium sulfate improves bone healing and repair, even when loaded with an antibiotic. 12,13 Calcium sulfate, optimized to resorb at a rate similar to that of new bone formation (several weeks to months) has been combined with antibiotics to eradicate existing bone infections in clinical and experimental situations. 2,5,[7][8][9][13][14][15][16] A calcium sulfate pellet, engineered to dissolve and elute antibiotic over a shorter period of time, may be advantageous for infection prevention.…”

mentioning

confidence: 99%

Preliminary in vitro evaluation of an adjunctive therapy for extremity wound infection reduction: Rapidly resorbing local antibiotic delivery

Jackson

Richelsoph

Courtney

et al. 2008

Journal Orthopaedic Research

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Despite the continuing advances in treatment of open fractures and musculoskeletal wounds, infection remains a serious complication. Current treatments to prevent infection utilize surgical debridement and irrigation, and high doses of systemic antimicrobial therapy. The aim of this work was to evaluate, in vitro, the potential of a fast-resorbing calcium sulfate pellet loaded with an antibiotic. The pellet could be used as an adjunctive therapy at the time of debridement and irrigation to reduce bacterial wound contamination. Small pellets containing a binder and calcium sulfate were engineered to resorb rapidly (within 24 h) and deliver high local doses of antibiotic (amikacin, gentamicin, or vancomycin) to the wound site while minimizing systemic effects. Results from dissolution, elution, and biological activity tests against P. aeruginosa and S. aureus were used to compare the performance of antibiotic-loaded, rapidly resorbing calcium sulfate pellets to antibiotic-loaded crushed conventional calcium sulfate pellets. Antibiotic-loaded rapidly resorbing pellets dissolved in vitro in deionized water in 12-16 h and released therapeutic antibiotic levels in phosphate buffered saline that were above the minimal inhibitory concentration for P. aeruginosa and S. aureus, completely inhibiting the growth of these bacteria for the life of the pellet. Crushed conventional calcium sulfate pellets dissolved over 4-6 days, but the eluates only contained sufficient antibiotic to inhibit growth for the first 4 h. These data indicate that fast-resorbing pellets can release antibiotics rapidly and at therapeutic levels. Adjunctive therapy with fast-acting pellets is promising and warrants further in vivo studies. ß

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“…Gypsum has been clinically used as a bone substitute material for more than a decade3,4) , and is now commercially available as Osteoset®1, [3][4][5][6].Therefore, it is undisputedly safe to be used as a precursor for HAP blocks. In addition, it should be noted that gypsum has setting ability -in other words, CaSO4.1/2H2O paste can set to form gypsum block.…”

Section: Hydroxyapatitementioning

confidence: 99%

Fabrication of Hydroxyapatite Block from Gypsum Block Based on (NH4)2HPO4 Treatment

Suzuki

Matsuya

Udoh

et al. 2005

Dental Materials Journal

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The aim of this study was to evaluate the feasibility of fabricating low-crystalline, porous apatite block using set gypsum as a precursor based on the fact that apatite is thermodynamically more stable than gypsum. When the set gypsum was immersed in 1 mol/L diammonium hydrogen phosphate aqueous solution at 100°C, it transformed to low-crystalline porous apatite retaining its original shape. The transformation reaction caused a release of sulfate ions due to an ion exchange with phosphate ions, thus leading to a decrease in the pH of the solution.Then, due to decreased pH, dicalcium phosphate anhydrous -which has similar thermodynamic stability at lower pH -was also produced as a by-product. Apatite formed in the present method was low-crystalline, porous B-type carbonate apatite that contained approximately 0.5 wt % CO3, even though no carbonate sources -except carbon dioxide from air -were added to the reaction system. We concluded therefore that this is a useful bone filler fabrication method since B-type carbonate apatite is the biological apatite contained in bone.

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Radiographic and Histologic Assessment of Calcium Sulfate in Experimental Animal Models and Clinical Use as a Resorbable Bone-Graft Substitute, a Bone-Graft Expander, and a Method for Local Antibiotic Delivery

Cited by 112 publications

References 1 publication

Function After Injection of Benign Bone Lesions with a Bioceramic

Function After Injection of Benign Bone Lesions with a Bioceramic

Preliminary in vitro evaluation of an adjunctive therapy for extremity wound infection reduction: Rapidly resorbing local antibiotic delivery

Fabrication of Hydroxyapatite Block from Gypsum Block Based on (NH4)2HPO4 Treatment

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