Fabrication of Hydroxyapatite Block from Gypsum Block Based on (NH4)2HPO4 Treatment

Suzuki, Yumiko; Matsuya, Shigeki; Udoh, K.; Nakagawa, Masaharu; Tsukiyama, Yoshihiro; Koyano, Kiyoshi; Ishikawa, Kunio

doi:10.4012/dmj.24.515

Cited by 30 publications

(20 citation statements)

References 18 publications

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“…We have proposed numerous novel methods to fabricate CAp blocks without the sintering process [7][8][9][10] . Using calcium carbonate as a precursor and via phosphatization in an appropriate phosphate solution, the precursor was transformed into CAp block with its original shape retained.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Sr-containing carbonate apatite as a bone substitute and its properties

et al. 2012

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Sr-containing carbonate apatite (SrCAp) specimens of varied Sr contents, ranging from 0 to 13.3 mol%, were prepared through a phosphate treatment of set gypsum-and-carbonate mixture at 100°C for 7 days. Effects of Sr content in SrCAp on microstructure, osteoblast-like cell (MC3T3-E1) attachment and proliferation, and alkaline phosphatase (ALP) activity were evaluated. Sr 2+ ion substituted Ca 2+ ion in the apatite lattice. Carbonate content was about 9-13.6 wt%, increasing in content level as Sr content increased. Sr addition benefited cell attachment but had no significant influence on cell proliferation, although the latter was inhibited at the highest Sr content. ALP activity reached a peak in specimen containing 3.4 mol% of Sr. The present study revealed that SrCAp is a promising candidate for use as a bone substitute material with good resorbabilty and osteoconductivity.

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Section: Introductionmentioning

confidence: 99%

Preparation of Sr-containing carbonate apatite as a bone substitute and its properties

et al. 2012

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“…Therefore, HAp block was fabricated when set gypsum was exposed to aqueous phosphate salt solution 8) . In the present study, the lack of carbonate content in gypsum is amply compensated by the abundant carbonate content in calcite.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of B-type carbonate apatite blocks by the phosphorization of free-molding gypsum-calcite composite

et al. 2008

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B-type carbonate apatite (CO3Ap) block may be an ideal artificial bone substitute because it is closer in chemical composition to bone mineral. In the present study, the feasibility to fabricate CO3Ap blocks was investigated using compositional transformation, which was based on the dissolution-precipitation reaction of a gypsum-calcite composite with freemolding behavior. For the compositional change, or phosphorization, gypsum-calcite composites of varying CaCO3 contents were immersed in 1 mol/L (NH4)3PO4 aqueous solution at 100°C for 24 hours. No macroscopic changes were found after the treatment, whereas microscopic change was observed at SEM level. X-ray diffraction, Fourier transform infrared spectroscopy and CHN analysis indicated that the composites were B-type CO3Ap containing approximately 6 -7 wt％ of CO3, a value similar to that of biological bone apatite. Diametral tensile strength of the CO3Ap block was approximately 1-3 MPa. Based on the results obtained, it was therefore concluded that gypsum-calcite was a good candidate for the fabrication of CO3Ap blocks, coupled with the advantage that the composite can be molded to any shape by virtue of the setting property of gypsum.

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“…Several methods have been proposed for the fabrication of apatite blocks based on dissolution-precipitation reaction using gypsum as a precursor. Treatment of set gypsum with diammonium hydrogen phosphate solution resulted in hydroxyapatite 15) . However, CO3Ap blocks cannot be prepared using this method since this system is free of carbonate ions.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of carbonate apatite blocks from set gypsum based on dissolutionprecipitation reaction in phosphate-carbonate mixed solution

et al. 2014

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Carbonate apatite (CO 3 Ap), fabricated by dissolution-precipitation reaction based on an appropriate precursor, is expected to be replaced by bone according to bone remodeling cycle. One of the precursor candidates is gypsum because it shows self-setting ability, which then enables it to be shaped and molded. The aim of this study, therefore, was to fabricate CO 3 Ap blocks from set gypsum. Set gypsum was immersed in a mixed solution of 0.4 mol/L disodium hydrogen phosphate (Na 2 HPO 4 ) and 0.4 mol/L sodium hydrogen carbonate (NaHCO 3 ) at 80-200°C for 6-48 h. Powder X-ray diffraction patterns and Fourier transform infrared spectra showed that CO 3 Ap block was fabricated by dissolution-precipitation reaction in Na 2 HPO 4 -NaHCO 3 solution using set gypsum in 48 h when the temperature was 100°C or higher. Conversion rate to CO 3 Ap increased with treatment temperature. CO 3 Ap block containing a larger amount of carbonate was obtained when treated at lower temperature.

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Fabrication of Hydroxyapatite Block from Gypsum Block Based on (NH4)2HPO4 Treatment

Cited by 30 publications

References 18 publications

Preparation of Sr-containing carbonate apatite as a bone substitute and its properties

Preparation of Sr-containing carbonate apatite as a bone substitute and its properties

Fabrication of B-type carbonate apatite blocks by the phosphorization of free-molding gypsum-calcite composite

Fabrication of carbonate apatite blocks from set gypsum based on dissolutionprecipitation reaction in phosphate-carbonate mixed solution

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