Preparation of Sr-containing carbonate apatite as a bone substitute and its properties

Abstract

Sr-containing carbonate apatite (SrCAp) specimens of varied Sr contents, ranging from 0 to 13.3 mol%, were prepared through a phosphate treatment of set gypsum-and-carbonate mixture at 100°C for 7 days. Effects of Sr content in SrCAp on microstructure, osteoblast-like cell (MC3T3-E1) attachment and proliferation, and alkaline phosphatase (ALP) activity were evaluated. Sr 2+ ion substituted Ca 2+ ion in the apatite lattice. Carbonate content was about 9-13.6 wt%, increasing in content level as Sr content increased. Sr addition benefited cell attachment but had no significant influence on cell proliferation, although the latter was inhibited at the highest Sr content. ALP activity reached a peak in specimen containing 3.4 mol% of Sr. The present study revealed that SrCAp is a promising candidate for use as a bone substitute material with good resorbabilty and osteoconductivity.

Characterization of Sr-substituted hydroxyapatite thin film by sputtering technique from mixture targets of hydroxyapatite and strontium apatite

“…Figure 3 shows SEM micrographs of the as-sputtered films of Sr0-Sr100. This result is consistent with the results of other studies [16,28]. After the hydrothermal treatment, the surface morphology was drastically changed (Fig.…”

Periodontal Regeneration Using Strontium-Loaded Mesoporous Bioactive Glass Scaffolds in Osteoporotic Rats

“…It has previously been demonstrated that Sr significantly influences osteoblastic differentiation by increasing alkaline phosphatase activity, real-time PCR for ALP and osteocalcin mRNA expression, and alizarin red staining for mineralization. Furthermore, recent investigations have also demonstrated a positive correlation of Sr incorporation into biomaterials [38], [39].…”

Strontium folate loaded biohybrid scaffolds seeded with dental pulp stem cells induce in vivo bone regeneration in critical sized defects

“…2 It is known, that the process of bone formation is tightly controlled by several systemic and in situ biological agents. Strontium is well known to impart positive effects on human mesenchymal stem cells (hMSC) differentiation, bone formation and remodeling ability in vivo [3][4][5][6][7][8] by a dual effect, namely the decrease of osteoblast activity and the increase of osteoclast activity, 9 constituting the main reasons to be used for treatment of osteoporosis during the last few decades, mainly in the form of complexes with organic acids such as ranelic acid via oral administration. In this regard, a controlled local release of strontium is the most desired administration "route" in order to overcome some of the drawbacks associated with existing methods of systemic administration.…”