Radiobiological effects of high-let particles: DNA strand breaks

Chatterjee, A.

doi:10.1016/0168-9002(89)90950-9

Cited by 17 publications

(4 citation statements)

References 21 publications

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“…To extend the modelling to the chemical stage of interaction one needs to know the spatial distribution of radiolysis products relative to DNA nucleotides . Chatterjee et al (1986), Chatterjee (1989 and Holley et al . (1990) used computer models taking into account the DNA structure and the related chemistry, using the concept of `core' and penumbra' for the track structure.…”

Section: Introductionmentioning

confidence: 91%

Modelling of Radiation Damage by¹²⁵I on a Nucleosome

Terrissol

1994

International Journal of Radiation Biology

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Studies of early physical interactions of ionizing radiation in biological medium have evolved from water cylinders or spheres to structured volumes representing nucleosomal DNA, based on spatial co-ordinates for each individual atom. Regarding the physico-chemical and chemical stages, the models of DNA have evolved from inactive geometrical objects to active participation of DNA in the reactions with the radical species. In this paper data are presented on the modelling of the interaction of low energy electrons with nucleosomal DNA. The nucleosome core unit has been modelled as a 146-bp helical DNA, containing > 9000 atoms, wound around the core unit. The yields of strand breaks for low energy electrons has been obtained by placing the nucleosome target in a liquid water environment and introducing a number of assumptions for the induction of strand breaks. The calculated results for the induction of ssb and dsb by 125I decays agree with experimental data, confirming the plausibility of this nucleosome model as well as the characterization of the interaction of ionizing radiation in terms of the energy deposition and the assumptions made for the strand breaks.

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Section: Introductionmentioning

confidence: 91%

Modelling of Radiation Damage by¹²⁵I on a Nucleosome

Terrissol

1994

International Journal of Radiation Biology

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“…Their detailed definition and calculation method were described elsewhere (31,32). One can see here that the local dose varies as the reciprocal of the square of the radial distance from the trajectory of a bombarding charged particle.…”

Section: Effect Of Different Bombarded Ionsmentioning

confidence: 99%

Conductometric Analysis for the Formation of Poly(Vinylidene Fluoride)-Based Ion Track Membranes

Yamaki¹,

Nuryanthi²,

Koshikawa³

et al. 2011

ECS Trans.

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Poly(vinylidene fluoride) (PVDF) films were irradiated with 450 MeV 129 Xe and 2.2 GeV 197 Au ion beams, and then the resulting latent tracks were etched in a 9 mol dm -3 aqueous KOH solution at 80ºC that had been poured into a conductometric cell. At the same time, the evolution of cylindrical nanopores was monitored by measuring the conductance through the membrane. This in-situ measurement enabled us to examine how the etching kinetics were affected by the various experimental conditions including the parameters (mass and velocity) of the bombarded ions and cell voltages applied between the electrodes. The track etch rate, V T , radial etch rate, V R , and pore radius reaching the final plateau significantly depended on the deposited energy within each track, which is represented by the linear energy transfer (LET). Interestingly, applying a higher voltage to the cell promoted track etching up to the breakthrough probably because the electrophoretic migration of dissolved products occurred out of each pore.

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“…Theoretical studies in radiation biology with high-LET charged particles have been helpful in understanding some types of DNA damage as double-strand breaks [8]. High-LET radiation features a highly structured deposition of energy along the charged particle tracks [9].…”

Section: Introductionmentioning

confidence: 99%

Fragmentation of Plasmid DNA Produced by Gamma Radiation: A Theoretical Approach

2012

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Breaks in DNA, resulting in fragmented parts, can be produced by ionizing radiation which, in turn, is the starting point in the search for novel physical aspects of DNA strands. Double-strand breaks in particular cause disruption of the DNA strand, splitting it into several fragments. In order to study effects produced by radiation in plasmid DNA, a new simple mechanical model for this molecule is proposed. In this model, a Morse-like potential and a high-LET component are used to describe the DNA-radiation interaction. Two power laws, used to fit results of the model, suggest that, firstly, distribution of fragment size is nonextensive and, secondly, that a transition phase is present in the DNA fragment distribution pattern.

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Radiobiological effects of high-let particles: DNA strand breaks

Cited by 17 publications

References 21 publications

Modelling of Radiation Damage by¹²⁵I on a Nucleosome

Modelling of Radiation Damage by¹²⁵I on a Nucleosome

Conductometric Analysis for the Formation of Poly(Vinylidene Fluoride)-Based Ion Track Membranes

Fragmentation of Plasmid DNA Produced by Gamma Radiation: A Theoretical Approach

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Radiobiological effects of high-let particles: DNA strand breaks

Cited by 17 publications

References 21 publications

Modelling of Radiation Damage by125I on a Nucleosome

Modelling of Radiation Damage by125I on a Nucleosome

Conductometric Analysis for the Formation of Poly(Vinylidene Fluoride)-Based Ion Track Membranes

Fragmentation of Plasmid DNA Produced by Gamma Radiation: A Theoretical Approach

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Modelling of Radiation Damage by¹²⁵I on a Nucleosome

Modelling of Radiation Damage by¹²⁵I on a Nucleosome