Radioaktive Markierung von Tropan‐Alkaloiden, III. Darstellung von ³H‐Atropin und ³H‐Nor‐(–‐)‐cocain Beschreibung einer Apparatur für Tritierungen mit ³H₂‐Gas

Abstract

3H‐Atropin (Aktivität: 16.5 mC/mMol) und 3H‐Nor‐(–‐)‐cocain (Aktivität: 2.5 mC/mMol) wurden durch Einwirkung von Tritium‐Gas auf Atropin und Nor‐(–‐)‐cocain in einer dafür besonders entwickelten Apparatur dargestellt.

Synthesis of Tropine-Labeled Atropine I

“…The resulting mass was heated at 100" for 7 min., and the excess acetyl chloride removed at 50", in vucuo, using a flash e~a p o r a t o r .~ Crystallization of the oily product, which otherwise required several days, was initiated by seeding with a crystal of pure O-acetyltropic acid.4 When stored for 2 4 hr., in a vacuum desiccator, over calcium chloride, the product crystallized as a solid mass which was immediately coiiverted to the acid chloride. To the 0-acetyltropic acid, contained in the original reaction vessel and 1 In some micro experiments, 395 mg. tropic acid and 0.36 ml. acetyl chloride were used.…”