Synthesis of Tropine-Labeled Atropine I

Synthesis of Tropine-Labeled Atropine III

“…For synthesis of the heterocycle, the Robinson condensation (9, 10) is inherently versatile and has been proven adaptable for microsynthesis (4,11). For synthesis of the heterocycle, the Robinson condensation (9, 10) is inherently versatile and has been proven adaptable for microsynthesis (4,11).…”

“…After suitable storage, N-rnethyl-l4C-tropinel4 was converted to the hydrochloride, in the exact manner described previously (4). lo The gas buret was filled with hydrogen, the system closed, and reduction continued with constant stirring, at room temperature, until the rate of gas uptake Microsynthetic methods for tropine and atropine are described in detail in the first two papers of this d a~~~n P & ; $~~i o $ ;~ : k: 2; ; Fhou, p2i & u~:Oa;layg;sfo;d~ Series (4, 5) and were modified only Slightly for the quate and storage for 3 months causes no decrease in atropine synthesis of N-meth~l-~~C-tro~ine and N-methylyi:ldTS;pe w-2 catalyst was used in earlier work, Reduction 14C-atropine.…”

“…tropanone was prepared from m e t h~l a r n i n e -~~c -HCI, succindialdehyde, and acetone dicarboxylic acid, according to previously described procedures (4,5). The earlier papers should be consulted for essential experimental details.…”