Synthesis of tropine-labeled atropine II Prototype synthesis for the preparation of tropine-14C and atropine-14C from arabinose-14C

Schmidt, Gilbert C.; Eling, Thomas E.; McOwen, John M.; Drach, John C.

doi:10.1002/jps.2600561116

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2009

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Cited by 8 publications

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“…Using the microsynthetic procedures described previously (7,9), three different tropine-labeled atropines were prepared. From citric-3-I4C acid, tropanone-3-14C (44%), and atropine-3-14C (26%) were synthesized with a specific activity of 1 mc./ mmole.…”

Section: Discussionmentioning

confidence: 99%

“…The reaction was studied in detail, a reproducible microcondensation procedure developed, and the microesterification of tropine and tropic acid standardized (7). At the same time, a prototype procedure was developed for the microsynthesis of succindialdehyde and tropine from arabinose (9) which would be used to label the 1,5,6, and 7 positions of atropine. At the same time, a prototype procedure was developed for the microsynthesis of succindialdehyde and tropine from arabinose (9) which would be used to label the 1,5,6, and 7 positions of atropine.…”

Section: Keyphrasesmentioning

confidence: 99%

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