Radioactive Iodine-Associated Cytomorphologic Alterations in Thyroid Follicular Epithelium: Is Recognition Possible in Fine-Needle Aspiration Specimens?

Sturgis, Charles D.

doi:10.1002/(sici)1097-0339(199909)21:3<207::aid-dc13>3.0.co;2-e

Cited by 17 publications

(3 citation statements)

References 15 publications

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“…Ogawa et al showed that treatment with radioactive iodine (RAI 131 ) deactivates the tumour suppressor gene that is commonly found in anaplastic thyroid cancer rather than differentiated thyroid cancer [24]. There are also some cytomorphological changes in thyroid follicular epithelium caused by radioactive iodine treatment, as reported by Stugis [25]. Radioactive iodine treatment plays a significant role in induction of cellular atypia with progressive metaplastic changes in patients with Graves' disease.…”

Section: Discussionmentioning

confidence: 99%

Rak tarczycy po terapii jodem radioaktywnym z powodu nadczynności tarczycy — opis serii przypadków i przegląd piśmiennictwa

Eyadeh

Al-Sarihin

Etewi

et al. 2017

Endokrynologia Polska

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Introduction: To assess the rate of thyroid cancer and mortality rate in a cohort of patients who received RAI 131 treatment for hyperthyroidism and to report the index cases' characteristics and management Material and methods: A cohort of 264 patients who received RAI 131 treatment for different causes of thyrotoxicosis were followed up over a period of 18 years (1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014) by physical exam, radiological evaluation and serial thyroid function tests. Results: During the follow up period, three cases of thyroid cancer were identified. The prevalence of thyroid cancer was 1.136% of cases who received RAI 131 . The relative risk was 378.79 (95% CI: 76.8 < RR < 1868.23). The P value was < 0.0000004 and the SMR is 1.99/1000. Conclusions: The prevalence of thyroid cancer was 1.136% in the cohort of patients treated with RAI

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Section: Discussionmentioning

confidence: 99%

Rak tarczycy po terapii jodem radioaktywnym z powodu nadczynności tarczycy — opis serii przypadków i przegląd piśmiennictwa

Eyadeh

Al-Sarihin

Etewi

et al. 2017

Endokrynologia Polska

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“…These antibodies also can stimulate angiogenesis, which contributes to thyroid tumor cell growth, by activating vascular endothelial growth factor [8]. Sturgis [9] reported cytomorphologic alterations in thyroid follicular epithelium, which is associated with RAI therapy. Before treatment, Graves' disease typically lack significant atypia, while after RAI therapy, nuclear atypia, and progressive cellular metaplasia could be seen microscopically.…”

Section: Discussionmentioning

confidence: 99%

Anaplastic Thyroid Carcinoma Following Radioactive Iodine Therapy for Graves' Disease

Kim

Jung

et al. 2013

Endocrinol Metab

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Radioactive iodine (RAI) therapy has been used as a treatment option for Graves' disease, and it has been widely accepted to be safe. On the other hand, some evidence suggests that RAI therapy is possibly associated with a small increased risk of thyroid cancer. Herein, we report a rare case of anaplastic thyroid carcinoma (ATC) associated with Graves' disease, following RAI treatment. A 42-year-old woman had been diagnosed with Graves' disease and although she was treated with an antithyroid drug, she remained in a hyperthyroid state, which led to two RAI treatments. More than 10 years later, the patient revisited our clinic due to hoarseness, dysphagia, and dyspnea, which had lasted for 2 months. Neck computed tomography suggested thyroid carcinoma and a lymph node biopsy showed metastatic papillary carcinoma. The patient underwent total thyroidectomy and was finally diagnosed as having an ATC. It is not clear if the occurrence of ATC reported here was influenced by the RAI therapy or alternatively, it may only represent the delayed recognition of a rare change in the natural history of Graves' disease. Nevertheless, this report is worthwhile since it presents a very rare case of ATC that occurred eleven years after the RAI therapy for Graves' disease.

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“…[195,196] L'analyse cytologique des nodules de la MB pose un problème diagnostique : certaines modifications morpho-cytologiques basedowiennes peuvent ressembler à celles observées lors du cancer papillaire. Les thérapeutiques employées, en particulier l'iode 131, peuvent également induire des altérations cytologiques.…”

Section: Quels Risques ?unclassified

Recommandations de la Société française d’endocrinologie pour la prise en charge des nodules thyroïdiens

2011

La Presse Médicale

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Radioactive Iodine-Associated Cytomorphologic Alterations in Thyroid Follicular Epithelium: Is Recognition Possible in Fine-Needle Aspiration Specimens?

Cited by 17 publications

References 15 publications

Rak tarczycy po terapii jodem radioaktywnym z powodu nadczynności tarczycy — opis serii przypadków i przegląd piśmiennictwa

Rak tarczycy po terapii jodem radioaktywnym z powodu nadczynności tarczycy — opis serii przypadków i przegląd piśmiennictwa

Anaplastic Thyroid Carcinoma Following Radioactive Iodine Therapy for Graves' Disease

Recommandations de la Société française d’endocrinologie pour la prise en charge des nodules thyroïdiens

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