Rak tarczycy po terapii jodem radioaktywnym z powodu nadczynności tarczycy — opis serii przypadków i przegląd piśmiennictwa

Abstract

Introduction: To assess the rate of thyroid cancer and mortality rate in a cohort of patients who received RAI 131 treatment for hyperthyroidism and to report the index cases' characteristics and management Material and methods: A cohort of 264 patients who received RAI 131 treatment for different causes of thyrotoxicosis were followed up over a period of 18 years (1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014) by physical exam, radiological evaluation and serial thyroid function tests. Results: During the follow up period, three cases of thyroid cancer were identified. The prevalence of thyroid cancer was 1.136% of cases who received RAI 131 . The relative risk was 378.79 (95% CI: 76.8 < RR < 1868.23). The P value was < 0.0000004 and the SMR is 1.99/1000. Conclusions: The prevalence of thyroid cancer was 1.136% in the cohort of patients treated with RAI

Downregulation of TSPAN13 by miR-369-3p inhibits cell proliferation in papillary thyroid cancer (PTC)

“…Currently, the preferred treatment for thyroid cancer is surgery, where complete excision is performed in approximately 86% of patients and partial in 12% of patients [4]. In selected patients (with FTC and PTC) radioactive iodine (RAI) remnant ablation is considered, to remove residual thyroid tissue and microscopic disease [5]. Nevertheless, surgical excision of the thyroid gland may damage the parathyroid glands and lead to disorders of calcium metabolism.…”

Risk and Prognosis of Thyroid Cancer in Patients with Graves’ Disease: An Umbrella Review

“…Exclusion criteria were (1) non-English articles, (2) articles whose full text was not available, (3) articles in which thyroid cancer risk in patients with GD was not the primary outcome [5,[23][24][25], (4) articles discussing the association between thyroid cancer and radioiodine-treated disease [26,27], (5) articles in which there was no evidence of clear statistical methodology used [28][29][30], (6) articles including case reports [31,32] and/or rare histological types of thyroid carcinoma [33].…”