Radical radiotherapy compared with surgery for advanced squamous cell carcinoma of the base of tongue

Pol, M. van de; Levendag, Peter C.; Bree, Remco R. de; Franssen, Jan Huib; Smeele, Ludwig E.; Nijdam, Wideke; Jansen, Peter P.; Meeuwis, Cees A.; Leemans, C. René

doi:10.1016/j.brachy.2004.04.002

Cited by 13 publications

(6 citation statements)

References 27 publications

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“…Eating in public and normalcy of diet was stated around 80% level (100% is normal), which compares well to our SOMA/LENT grade 1 for dysphagia and taste alteration. There is no variable in the SOMA/LENT scale for understandability of speech, which was rated in 90% level in previous studies [4, 5]. We noticed only 1 patient with that problem in our material.…”

Section: Discussionmentioning

confidence: 73%

“…In a large review of the literature it seems clear that surgery and postoperative EBRT yields worse the functional outcome [6]. There are two studies with long-term functional outcome in 30 [4] and 8 patients [5], respectively, evaluated by the performance status scale proposed by List et al [35]. Eating in public and normalcy of diet was stated around 80% level (100% is normal), which compares well to our SOMA/LENT grade 1 for dysphagia and taste alteration.…”

Section: Discussionmentioning

confidence: 99%

“…Xerostomia was rated ( n = 8) [5] as 3.3 in the VAS measure (0 = no xerostomia) compared to SOMA/LENT grade 2 (partial and persistent) in our series. The median values of the WHO-performance and the global quality of life were very good in our long-term follow up.…”

Section: Discussionmentioning

confidence: 99%

“…In two papers surgery plus postoperative external beam radiotherapy (EBRT) with combined EBRT plus brachytherapy (BT) boost were compared. Local control and survival were similar but they presented better functional performance with EBRT+BT [4, 5]. The full dose of EBRT alone is also a feasible alternative [6] in the primary treatment.…”

Section: Purposementioning

confidence: 99%

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Clinical Investigations Pulsed dose rate brachytherapy as the boost in combination with external beam irradiation in base of tongue cancer. Long-term results from a uniform clinical series

Johansson

Karlsson²,

Reizenstein

et al. 2011

jcb

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PurposeTo evaluate long time outcome with regard to local tumour control, side effects and quality of life of combined pulsed dose rate (PDR) boost and hyperfractionated accelerated external beam radiotherapy (EBRT) for primary base of tongue (BOT) cancers.Material and methodsBetween 1994 and 2007, the number of 83 patients were treated with primary T1-T4 BOT cancers. Seven patients (8%) were T1-2N0 (AJCC stage I-II) and 76 (92%) patients were T1-2N+ or T3-4N0-2 (AJCC stage III-IV). The mean estimated primary tumour volume was 15.4 (1-75) cm3. EBRT was given with 1.7 Gy bid to 40.8 Gy to primary tumour and bilateral neck lymph nodes in 2.5 weeks. PDR boost of 35 Gy and a neck dissection in clinical node positive case was performed 2-3 weeks later. The patients were followed for a median of 54 (2-168) months.ResultsThe 2-, 5- and 10-years rates of actuarial local control were 91%, 89% and 85%, overall survival 85%, 65% and 44%, disease free survival 86%, 80% and 76%, respectively. The regional control rate was 95%. Six patients (7%) developed distant metastases. A dosimetric analysis showed a mean of 100% isodose volume of 58.2 (16.7-134) cm3. In a review of late complications 11 cases of minor (13%) and 5 of major soft tissue necroses (6%), as well as 6 cases of osteoradionecroses (7%) were found. The patients median subjective SOMA/LENT scoring at last follow up was as follow: grade 0 for pain and trismus, grade 1 for dysphagia and taste alteration, and grade 2 for xerostomia. Global visual-analogue-scale (VAS) scoring of quality of life was 8.ConclusionLocal and regional tumour control rate was excellent in this treatment protocol. The data shows the PDR boost as at least as effective as published continuous low dose rate (CLDR) results.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Purposementioning

confidence: 99%

See 2 more Smart Citations

Clinical Investigations Pulsed dose rate brachytherapy as the boost in combination with external beam irradiation in base of tongue cancer. Long-term results from a uniform clinical series

Johansson

Karlsson²,

Reizenstein

et al. 2011

jcb

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“…arterial chemotherapy [14], or interstitial radiotherapy [10,15,16]. However, super-selective intra-arterial chemotherapy and interstitial radiotherapy cannot be performed at every institution as mentioned above, and with concurrent radiochemotherapy, higher doses can cause severe damage [17].…”

Section: Discussionmentioning

confidence: 97%

Treatment results for 84 patients with base of tongue cancer

Yoshimoto

Kawabata

Mitani

et al. 2007

Acta Oto-Laryngologica

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The main treatment options were radiotherapy for primary lesions < or = T2 and surgery for primary lesions > or = T3. Overall disease-specific 5-year cumulative survival rate was 59.8%, but there was no significant difference in survival rate at each stage between the two treatments. Among patients who died of the primary disease, the area that was most difficult to control was the superior margin of the lateral wall of the oropharynx (n=7). The incidence of contralateral or retropharyngeal lymph node metastasis was low if tumors neither crossed the midline nor infiltrated the lateral wall. While total laryngectomy was performed on 48 patients, the larynx was operatively preserved in 5 T3 patients and one T4 patient.

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Concurrent chemoradiotherapy compared with surgery and adjuvant radiotherapy for oral cavity squamous cell carcinoma

et al. 2014

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Radical radiotherapy compared with surgery for advanced squamous cell carcinoma of the base of tongue

Cited by 13 publications

References 27 publications

Clinical Investigations Pulsed dose rate brachytherapy as the boost in combination with external beam irradiation in base of tongue cancer. Long-term results from a uniform clinical series

Clinical Investigations Pulsed dose rate brachytherapy as the boost in combination with external beam irradiation in base of tongue cancer. Long-term results from a uniform clinical series

Treatment results for 84 patients with base of tongue cancer

Concurrent chemoradiotherapy compared with surgery and adjuvant radiotherapy for oral cavity squamous cell carcinoma

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