Concurrent chemoradiotherapy compared with surgery and adjuvant radiotherapy for oral cavity squamous cell carcinoma

Gore, Sinclair M.; Crombie, A.; Batstone, Martin; Clark, Jonathan

doi:10.1002/hed.23626

Cited by 64 publications

(56 citation statements)

References 15 publications

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“…The reported 5-year disease-specific survival was 68% in the surgery arm versus 12% in the chemoradiation arm (p = 0.038) [7] . Similar conclusions have been reported in retrospective studies by Gore et al [8] .…”

Section: Surgery As the Treatment Option In Oral Cancersupporting

confidence: 81%

Preoperative Chemotherapy and Metronomic Scheduling of Chemotherapy in Locally Advanced Oral Cancers

et al. 2016

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Locally advanced oral cavity cancers are treated with a multi-modality approach. Surgery is the most efficient local modality in comparison to chemoradiation in oral cancers. Preoperative chemotherapy has failed its expectations to improve disease-free survival or overall survival in resectable oral cancers. Its use as an organ preservation tool is being studied. Induction chemotherapy followed by assessment for surgery is an appropriate option for borderline resectable or technically unresectable oral cancer. Metronomic chemotherapy is being studied as a bridge to surgery and as adjuvant chemotherapy in locally advanced oral cancers. The role of induction chemotherapy in unresectable oral cancers is unproven. Metronomic chemotherapy has shown improved progression-free survival and overall survival in oral cancers in comparison to intravenous cisplatin. A phase 3 study for confirmation of this finding has begun.

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Section: Surgery As the Treatment Option In Oral Cancersupporting

confidence: 81%

Preoperative Chemotherapy and Metronomic Scheduling of Chemotherapy in Locally Advanced Oral Cancers

et al. 2016

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“…Usually, surgical treatment is preferred in the initial oral cancer, and the cases of progressed oral cancer with cervical lymph node metastasis can be provided with surgical treatment along with chemotherapy and radiation therapy [22]. Previous studies reported that overall survival and disease-specific survival was significantly higher in the surgically treated group compared with no surgery group in oral cavity squamous cell carcinoma [23–25]. Surgery and/or radiation therapy provides disease-specific survival benefit as compared with no therapy within the head and neck region [26].…”

Section: Discussionmentioning

confidence: 99%

“…A main meta-analysis showed only a small significant survival benefit in favour of chemotherapy, so the routine use of chemotherapy is debatable [31]. Studies about oral cancer also showed that combination therapy with chemotherapy after surgical treatment is not significantly better than those who received only surgical treatment or surgery plus radiotherapy [23]. Results from this study suggest that surgery combined with chemotherapy or concurrent chemoradiotherapy may not be significantly associated with overall survival of oral cancer after adjusting for the effect of gender, age, BMI, occupation, origin, education, drinking, smoking, family history, clinical stage, pathological grading.…”

Section: Discussionmentioning

confidence: 99%

Prospective study on factors affecting the prognosis of oral cancer in a Chinese population

et al. 2016

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This study was performed to identify the factors affecting prognosis of oral cancer patients. 1240 pathologically confirmed oral cancer patients were included. The sociodemographic and clinical characteristics of all patients were collected. Univariate and multivariate Cox proportional hazards models were used to assess potential prognostic factors for survival. 1240 oral cancer patients were followed up for 49235.00 person months, and the 5-year overall survival rate was 64.38%. Both univariate and multivariate Cox regression analysis indicated that Body Mass Index < 18.5 kg/m2 (vs 18.5–23.9 kg/m2), age ≥ 55 years (vs < 55 years), clinical stages of II-IV (vs stage I), and poor differentiation (vs well differentiation) were associated with worse survival of oral cancer patients. While surgery (vs non-surgery) and origin of urban area (vs rural area) were protective factors. However, no significant association was found between adjuvant therapy and survival in oral cancer patients.

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“…The primary choice of treatment will normally be surgery, with or without adjuvant radiotherapy [1]. If the functional consequences of surgery would reduce the quality of life to an unacceptable extent, the tumour is considered ‘functionally inoperable’ [2], and organ-sparing chemoradiation treatment will provide a better alternative.…”

Section: Introductionmentioning

confidence: 99%

Predicting 3D lip shapes using facial surface EMG

et al. 2017

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AimThe aim of this study is to prove that facial surface electromyography (sEMG) conveys sufficient information to predict 3D lip shapes. High sEMG predictive accuracy implies we could train a neural control model for activation of biomechanical models by simultaneously recording sEMG signals and their associated motions.Materials and methodsWith a stereo camera set-up, we recorded 3D lip shapes and simultaneously performed sEMG measurements of the facial muscles, applying principal component analysis (PCA) and a modified general regression neural network (GRNN) to link the sEMG measurements to 3D lip shapes. To test reproducibility, we conducted our experiment on five volunteers, evaluating several sEMG features and window lengths in unipolar and bipolar configurations in search of the optimal settings for facial sEMG.ConclusionsThe errors of the two methods were comparable. We managed to predict 3D lip shapes with a mean accuracy of 2.76 mm when using the PCA method and 2.78 mm when using modified GRNN. Whereas performance improved with shorter window lengths, feature type and configuration had little influence.

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Concurrent chemoradiotherapy compared with surgery and adjuvant radiotherapy for oral cavity squamous cell carcinoma

Abstract: Treatment by surgery + adjuvant RT for advanced oral cavity SCC resulted in better disease control than treatment with CRT. This supports traditional surgical treatment algorithms for oral cavity cancer.

Cited by 64 publications

References 15 publications

Preoperative Chemotherapy and Metronomic Scheduling of Chemotherapy in Locally Advanced Oral Cancers

Preoperative Chemotherapy and Metronomic Scheduling of Chemotherapy in Locally Advanced Oral Cancers

Prospective study on factors affecting the prognosis of oral cancer in a Chinese population

Predicting 3D lip shapes using facial surface EMG

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