Radiation Therapy for Life- or Function-threatening Infant Hemangioma

Ogino, Ichiro; Torikai, Katsuyukí; Kobayasi, Shinji; Aida, Noriko; Hata, Masaharu; Kigasawa, Hisato

doi:10.1148/radiology.218.3.r01mr04834

Cited by 53 publications

(37 citation statements)

References 30 publications

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“…In view of this life-threatening condition, the need for rapid correction of the coagulation disorder cannot be overemphasized. If treated with corticosteroids, anticoagulants, antiplatelets, antifibrinolytics, interferon, radiation, or new antiangiogenic factors, the time to reach an acceptable hematological response has been reported to range from a few days to months, definitely longer than if compared to embolization, and not without complications (11,12,14). In our two patients, platelets and fibrin values rose to safe levels within 24 hours after embolization, similar to that reported in other published case reports (3,19).…”

Section: Discussionsupporting

confidence: 88%

Transarterial embolization of giant liver hemangiomas associated with kasabach-merritt syndrome: a case report

Malagari

Alexopoulou²,

Dourakis³

et al. 2007

Acta Radiol

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Of 22 patients with symptomatic giant liver hemangiomas referred for embolization, two females (52 and 74 years) had Kasabach-Merritt syndrome (KMS). Hematocrit values were observed to be 33% and 29%, platelets 4000 and 5400/mm(3), and fibrinogen 98 and 77 mg/dl, respectively. Lesion diameters were 7 and 14 cm, respectively. Hepatic angiography revealed excessive vascular lakes typical of cavernous hemangiomas. Microspheres of 40-300 microm were superselectively injected under fluoroscopic guidance until cessation of flow. Coil packing of the feeding hepatic artery was additionally used in one patient. The procedure was uneventful in both. Partial restoration of platelet count was observed immediately; fibrinogen levels and platelets were restored completely in one patient and partially in the other, without remissions at 2-year follow-up.

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Section: Discussionsupporting

confidence: 88%

Transarterial embolization of giant liver hemangiomas associated with kasabach-merritt syndrome: a case report

Malagari

Alexopoulou²,

Dourakis³

et al. 2007

Acta Radiol

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“…There was assessed progeny of irradiated women in their young age and the significant higher numbers of neural tube defects were observed [44]. Nowadays in the era of lasers, radiotherapy for hemangioma was abandoned, however, some authors appreciate this method in life-or function-threatening hemangiomas [45].…”

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma as a long-term effect after skin vascular malformation radiotherapy

Mańkowski¹,

Osmola‐Mańkowska²,

Olszański³

et al. 2012

pdia

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A b s t r a c tIn the past, vascular anomalies were divided into vascular malformations and vascular tumors. Radiotherapy was one of the leading methods of treatment for vascular malformations and infantile haemangiomas in the past and considered as harmless in those days. Many years later it turned out that management was not necessary and dangerous, even responsible for possible skin cancers appeared within areas exposed to radiotherapy in the future. The case report shows the presence of squamous cell carcinoma within the irradiated vascular malformation of the frontotemporal area in early childhood. The lesion was surgically removed, the defect was covered by split thickness skin graft. The histopathological evaluation confirmed the carcinoma as well as its complete resection. Assessing the adult patients with vascular anomaly one should be aware of possible radiation therapy for that malformation in the past, then the evaluation of the skin must be careful and focused on possible neoplasmatic lesions. K Ke ey y w wo or rd ds s: : radiotherapy, vascular malformations, squamous cell carcinoma.

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“…Combination with arterial embolization should be considered at any time when good feeding arteries are found. Bone growth disorder such as shortening of the extremities was observed in cases of long-bone irradiation with 12-15 Gy, and muscle atrophy was reported in cases receiving 10-16 Gy irradiation [9]. To avoid the late effects of irradiation such as joint contracture, skin burn, and secondary cancer, the total irradiation dose should be kept as low as possible, not exceeding 10 Gy [10].…”

Section: Discussionmentioning

confidence: 99%

Vincristine-resistant Kasabach–Merritt phenomenon successfully treated with low-dose radiotherapy

et al. 2010

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Radiation Therapy for Life- or Function-threatening Infant Hemangioma

Abstract: Radiation therapy (in doses of < or = 10 Gy in 2-Gy fractions) is indicated for life-threatening hemangiomas and for some function-threatening hemangiomas.

Cited by 53 publications

References 30 publications

Transarterial embolization of giant liver hemangiomas associated with kasabach-merritt syndrome: a case report

Transarterial embolization of giant liver hemangiomas associated with kasabach-merritt syndrome: a case report

Squamous cell carcinoma as a long-term effect after skin vascular malformation radiotherapy

Vincristine-resistant Kasabach–Merritt phenomenon successfully treated with low-dose radiotherapy

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