Radiation Safety With Use of I-125 Seeds for Localization of Nonpalpable Breast Lesions

Pavlicek, William; Walton, Heidi A.; Karstaedt, Patricia J.; Gray, Richard

doi:10.1016/j.acra.2006.03.017

Cited by 70 publications

(69 citation statements)

References 6 publications

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“…The rate of positive margins in our study was 6%, which is at least comparable to the 8% rate reported by Gray et al (14)(15)(16)(17) and is well below the rate of 50,9% for excisions utilizing wire localization that was reported by Velanovic et al (29), both studies in non-palpable breast tumours. In a another prospective randomized trial of radioactive seed localization versus wire localization of non-palpable breast lesions, Hughes et al (30) found that radioactive seed localization resulted in a 35% relative improvement in the rate of negative margins in the first specimen and a 62% relative improvement in the rate of re-operation for positive margins.…”

Section: Lymph Node Statussupporting

confidence: 62%

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Identification of residual breast tumour localization after neo-adjuvant chemotherapy using a radioactive 125 Iodine seed

Riet

Maaskant

Creemers

et al. 2010

European Journal of Surgical Oncology (EJSO)

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. M A N U S C R I P T A C C E P T E D ARTICLE IN PRESS M A N U S C R I P T A C C E P T E D ARTICLE IN PRESS3 AbstractIntroduction The use of neo-adjuvant chemotherapy has increased in the treatment of loco-regionally

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Section: Lymph Node Statussupporting

confidence: 62%

“…(15)(16) The 125 Iodine ( 125 I) labelled titanium seed has been described for the localisation of non palpable breast tumours. (14)(15)(16)(17). We used the 125 I seed to mark the tumour bed in patients who were planned to receive neo-adjuvant chemotherapy for breast M A N U S C R I P T…”

Section: Introductionmentioning

confidence: 99%

Identification of residual breast tumour localization after neo-adjuvant chemotherapy using a radioactive 125 Iodine seed

Riet

Maaskant

Creemers

et al. 2010

European Journal of Surgical Oncology (EJSO)

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“…The removed breast tissue requires special handling by the surgeon (Jakub et al, 2010) and pathologist (Graham et al, 2012). It also requires all of the involved personnel to pay careful attention to all of the radiation safety procedures and nuclear regulatory issues (Pavlicek et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Radioactive Seed Localization for Nonpalpable Breast Lesions in a Community Hospital Setting

Wheeler

Harrod

Liu

et al. 2016

CCO

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“…Due to 125Iodine radioemission, doubts arose regarding the doses absorbed by the patient and by the medical team. According to Pavlicek et al 23 , the maximum dose deposited in the residual breast that received the seed implant is rather low, around 2 cGy, equivalent to the dose of two X-ray incidences of a routine mammography. A survey on the amount of radiation received by the surgical team showed that no one received a dose higher than the environmental level 24 , proving the absence of risk to the medical staff, to the patient and to the general population.…”

Section: Introductionmentioning

confidence: 99%

Use of 125iodine seeds (ROLLIS) for intra-operative localization of nonpalpable breast lesions: analysis of the implant of 338 seeds in 284 patients

A¹,

Franca²,

Oliveira³

et al. 2017

Rev. Bras. Mastol. (Impr.)

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To analyze the feasibility, efficacy and results of the use of 125Iodine seeds for intra-operative localization of nonpalpable breast lesions. Method: Retrospective review of 284 patients, referred by various breast specialist surgeons, with radiologically detected but clinically nonpalpable microcalcifications or nodules, submitted to pre-operatory 125Iodine seed implant, between July 2012 and September 2016. A total of 338 seeds were implanted in ordinary radiologic departments, supported by ultrasonography or mammography exams, chosen according to the morphologic aspect of the lesion. Radioguided surgical procedure took place on the same day or few days after the implant of the seeds, with the help of a radiation detector called Gamaprobe, which directs the surgeons towards the radioactive seeds and to the lesion to be resected. Results: All implants were performed as outpatient procedures, with patients immediately returning to their daily activities. No complications such as pain, bleeding, infeccion and haematoma were recorded. Pathologists had no difficulty in preparing the surgical specimens for histopathologic analysis. Surgical safety margins were considered adequate in all pathologic reports, with no need for re-operations. The healing process was not jeopardized by radiation, and the surgeons were pleased with the improvement on intraoperative lesions localizations and shortening on operatory time. Cosmetic results were well accepted by the patients. Conclusion: The 125Iodine seed implant is an effective alternative method for intraoperative localization of radiologically detectable and clinically nonpalpable breast lesions.

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Radiation Safety With Use of I-125 Seeds for Localization of Nonpalpable Breast Lesions

Cited by 70 publications

References 6 publications

Identification of residual breast tumour localization after neo-adjuvant chemotherapy using a radioactive 125 Iodine seed

Identification of residual breast tumour localization after neo-adjuvant chemotherapy using a radioactive 125 Iodine seed

Radioactive Seed Localization for Nonpalpable Breast Lesions in a Community Hospital Setting

Use of 125iodine seeds (ROLLIS) for intra-operative localization of nonpalpable breast lesions: analysis of the implant of 338 seeds in 284 patients

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