Radiation-Induced Ultrastructural Changes in Lysosomes. I. Cytochemical Analysis

Modulation of serum phosphatases activity in Swiss albino mice against gamma irradiation by Mentha piperita Linn.

“…An enhanced golgi activity and peroxidation of lysosomal membranes after irradiation causing lysis of membrane and leakage of the enzymes is attributed to an increased acid phosphtase level (Wills and Wilkinson, 1966). The release of enzymes from lysosomes may be due to activation of pre-existing latent enzymes or due to the synthesis of new lysosomes as a consequence of radiation (Rene et al, 1971). It is well known that radiation increases the permeability of membranes for several materials and hence an increase in the serum acid phosphatase activity is seen after irradiation.…”

Characterization of chloroquine-induced autophagic vacuoles isolated from rat liver

“…A relatively high incidence of cellular autophagy is frequently exhibited by cells of tissues undergoing regeneration (Becker and Lane, 1965), atrophy (Helminen, 1976), differentiation (Scharrer, 1966) or embryological development (Locke and Collins, 1965;Locke and McMahon, 1971). The appearance of autophagic vacuoles in tissues can be drastically increased following exposure of animals to diverse chemical, physical, and biological agents, such as: glucagon (Ashford and Porter, 1962;Arstila and Trump, 1968;Deter, 1971Deter, , 1975a, chloroquine (Abraham et al, 1968), mitotic inhibitors (Arstila et al, 1974;Hirsimaki et al, 1975), cyclic AMP (Hirsimaki et al, 1975;Shelburne and Trump, 1968), actinomycin D (Arstila and Trump, 1968;Kovacs, 1972;Shelburne et al, 1973), DDT (Gray et al, 1970), hypoxia (Abraham et al, 1967;Cole et al, 1971), and ionizing irradiation (Hendlee and Alders, 1968;Rene et al, 1971;Jordan et al, 1972).…”

Ultracytochemical Changes in the Distribution of Acid Phosphatase and Thiamine Pyrophosphatase Activity in the Nerve Cells of the Cerebrum of Thiamine-Deficient Rats

“…Increase in ACPase activity by radiation is related to cellular necrobiosis (52). ACPase positive large membrane-delimited bodies with heterogenous content tend also to accumulate (21), and accordingly these bodies apparently represent residual bodies originated from autophagic vacuoles.…”