Modulation of serum phosphatases activity in Swiss albino mice against gamma irradiation by Mentha piperita Linn.

Abstract

The modulatory influence of mentha oil (Mentha piperita Linn.) against a lethal dose (8.0 Gy) of gamma irradiation on the activities of serum phosphatases in Swiss albino mice was studied at various post-irradiation intervals between 6 h and 30 days. Mentha oil (40 microL/animal/day) given orally for 3 consecutive days prior to whole-body irradiation (8.0 Gy) showed a modulation of activity of serum phosphatases. The values of acid phosphatase activities were significantly higher in the irradiated groups throughout the experiment compared with the mentha treated unirradiated animals. However, the acid phosphatase activity of mentha treated irradiated animals showed a significant decline over untreated irradiated animals at all autopsy intervals, which attained the normal value on day 5. On the contrary, a marked decrease in serum alkaline phosphatase activity was noted in both irradiated groups but in the mentha treated irradiated group the values of alkaline phosphatase activity were found to be significantly higher than the respective control during the period of study being normal at day 5 post-irradiation and onwards.

Influence of the Leaf Extract of Mentha arvensis Linn. (Mint) on the Survival of Mice Exposed to Different Doses of Gamma Radiation

“…Recently, another species of mint (Mentha piperta) has been reported to inhibit the radiation-induced elevation in the alkaline and acid phosphatases [34]. Similarly, other plant extracts like Ocimum sanctum [8,9,17], Panax ginseng [57], Spirulina platensis [27], Chlorella vulgaris [38], garlic [41], Ginkgo biloba [3] and Phyllanthus niruri [48] have been reported to be radioprotective.…”

Radioprotective potential of mint: A brief review

“…[20] Mint reduces Serum Phosphatases Studies by Samarth et al, [55,56] have shown that both oil as well as the aqueous extract of M. piperita modulated levels of serum phosphatases at different assay time points (6 h and 30 days post-irradiation). Exposure of Swiss albino mice to lethal dose of γ irradiation (8.0 Gy) caused a marked increase in the activities of serum phosphatases and acid phosphatase.…”

Mentha piperita as a pivotal neuro-protective agent against gamma irradiation induced DNA fragmentation and apoptosis

“…Many synthetic as well as natural agents have the efficacy as a protector against radiation injuries (Nair et al 2001). Plant extracts such as Mentha (Samarth et al 2002) have been found to have radioprotective effects in mammals. Mentha piperita (Linn.…”