Influence of the Leaf Extract of Mentha arvensis Linn. (Mint) on the Survival of Mice Exposed to Different Doses of Gamma Radiation

Jagetia, Ganesh Chandra; Baliga, Manjeshwar Shrinath

doi:10.1007/s00066-002-0841-y

Cited by 60 publications

(41 citation statements)

References 36 publications

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“…17 • AME + irradiation: This group of animals was injected with AME intraperitoneally once daily for 5 consecutive days before exposure to γ radiation. 18 …”

Section: Preparation Of Drugs and Mode Of Administrationmentioning

confidence: 97%

Fruit Extract of Aegle marmelos Protects Mice Against Radiation-Induced Lethality

2004

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The radioprotective effect of a hydroalcoholic extracted material from the fruit of Aegle marmelos (AME) was studied in mice exposed to different doses of gamma radiation. The optimum dose for radioprotection was determined by administering 0, 5, 10, 20, 40, or 80 mg/kg body weight of AME intraperitoneally (ip) once daily, consecutively for 5 days before exposure to 10 Gy of gamma radiation. A total of 20 mg/kg of AME for 5 consecutive days before irradiation was found to afford maximum protection as evidenced by the highest number of survivors after 30 days postirradiation. Animals from all groups were monitored for 30 days postirradiation for development of symptoms of radiation sickness and mortality. Treatment of mice with AME before exposure to different doses of gamma radiation reduced the severity of symptoms of radiation sickness and mortality with all exposure doses. This was accompanied by an increase in number of survivors in the AME + irradiation group when compared with the concurrent sterile physiological saline (SPS) + irradiation group. AME pretreatment protected mice against the gastrointestinal as well as bone marrow deaths, as evidenced by the greater number of survivors on day 10 or 30, respectively. LD50/30 was found to be 8.2 Gy for the SPS + irradiation group, while it was 8.8 Gy for AME + irradiation. The dose-reduction factor (DRF) was found to be 1.1 for AME + irradiation group. The acute toxicity study of AME showed that it was nontoxic up to a dose of 6 g/kg body weight, the highest drug dose that could be administered. Irradiation of animals resulted in a dose-dependent elevation in lipid peroxidation in liver, kidney, stomach, and intestine of mice. Conversely, GSH concentration declined in a dose-dependent manner. Treatment of animals with AME before irradiation caused a significant decrease in the lipid peroxidation accompanied by a significant elevation in the GSH concentration in liver, kidney, stomach, and intestine of mice determined at 31 days postirradiation.

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“…17 • AME + irradiation: This group of animals was injected with AME intraperitoneally once daily for 5 consecutive days before exposure to γ radiation. 18 …”

Section: Preparation Of Drugs and Mode Of Administrationmentioning

confidence: 97%

Fruit Extract of Aegle marmelos Protects Mice Against Radiation-Induced Lethality

2004

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“…Plant extracts eliciting radioprotective efficacy contain a plethora of compounds including antioxidants, immunostimulants, cell proliferation stimulators, anti-inflammatory and antimicrobial agents, some of which may act in isolation as well as in combination with other constituents from the same plant [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Using of Coffee and Cardamom Mixture to Ameliorate Oxidative Stress Induced in γ-irradiated Rats

Hamzaa¹,

Osman²

2012

Biochem Anal Biochem

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Human exposure to ionizing radiation induced overproduction of free radicals leading to oxidative stress. This study aims to evaluate the possibility of using of coffee and cardamom mixture, as natural antioxidant compounds, to ameliorate the damage effect of oxidative stress. Phenolic contents in coffee and essential oils in cardamom were identified by using HPLC chromatography and GC/MS analysis. Four groups of adult male rats were used; the control group (A), the second group (B) received orally mixture extract of coffee and cardamom (60 mg/100g body weight) for 8 weeks, the third group (C) γ-irradiated (6 GY) and the fourth group (D) received orally mixture extract for 8 weeks and exposed to γ-irradiation at the 4th week. The results revealed that the administration of mixture extract of coffee and cardamom were significantly reduced the damage effect induced by γ-irradiation exposure. Accordingly, it could be concluded that, via the adjustment of the antioxidant status, decreasing the releasing of lipid peroxides and the subsequent amending of different biochemical parameters and some hormones, mixture of coffee and cardamom could ameliorate the hazardous effects of oxidative stress induced by irradiation exposure.

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“…[1] There are many investigations which proved the potential of plant extract as radioprotective. Some of the plant's extract having potential radioprotective are Gingko biloba, [2] Centella asiatica, [3] Hippophae rhamnoides, [4] Osimum sanctum, [5] Panax ginseng, [6] Podophyllum hexandrum, [7] Tinospora cordifolia, [8] Emblica officinalis, [9] Phyllanthus amarus, [10] Amaranthus paniculatus, [11] Piper longum, [12] Syzigium cumini, [13] Mentha arvensis, [14] Mentha piperita, [15] Zingiber officinale, [16] Ageratum conyzoides, [17] Aegle marmelos [18] and Aphanamixis polystachya. [19] Bixa oreallana is a shrub used as an ornamental plant in India and is best known as the source of the natural pigment annatto, produced from the fruit.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of Bixa orellana L. against radiation induced chromosomal aberration in Swiss Albino Mice.

Karchuli¹,

Ganesh²

2009

Int. J. Phytomed

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Radioprotective effect of hydroalcoholic extract of seeds of Bixa orellana have been studied by examining chromosome aberration in cells of bone marrow in irradiated mice. Healthy adult Swiss mice were injected intraperitoneally (ip) with 500 mg kg -1 body weight, 1000 mg kg -1 of or double distilled water (DDW). They were exposed to whole body irradiation of 2.0 Gy gamma radiation 30 min later. After 24 h, chromosomal aberrations were studied in the bone marrow of the femur by routine metaphase preparation after colchicine treatment. Radiation (4.0 Gy) increased the number of aberrant cells from less than 1% in controls to almost 20%. Pretreatment with the extract compounds resulted in a significant reduction in the percentage of aberrant metaphases as well as in the different types of aberration scored. The extract was not toxic at 1500 mg kg -1 body weight. Being non toxic and easily available natural source Bixa orellana extract may be use for as radioprotective for human beings.

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Influence of the Leaf Extract of Mentha arvensis Linn. (Mint) on the Survival of Mice Exposed to Different Doses of Gamma Radiation

Abstract: From our study it is clear that mint extract provides protection against the radiation-induced sickness and mortality and the optimum protective dose of 10 mg/kg is safe from the point of drug-induced toxicity.

Cited by 60 publications

References 36 publications

Fruit Extract of Aegle marmelos Protects Mice Against Radiation-Induced Lethality

Fruit Extract of Aegle marmelos Protects Mice Against Radiation-Induced Lethality

Using of Coffee and Cardamom Mixture to Ameliorate Oxidative Stress Induced in γ-irradiated Rats

Protective effect of Bixa orellana L. against radiation induced chromosomal aberration in Swiss Albino Mice.

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