Radiation-induced chromosomal aberrations in human lymphocytes. I. Dependence on the dose of gamma-rays and an anomaly at low doses

Low Doses of Gamma-Radiation Induce Nonlinear Dose Responses in Mammalian and Plant Cells

“…Many years ago it was shown by Russel (1965) that the mutation yield per unit dose was higher at low doses of radiation than at high doses. Similar results were obtained by studying radiation-induced cytogenetic damage (Luchnik and Sevankaev, 1976;Pohl-Rulling et al, 1983;Lloyd et al, 1988;Zaichkina et al, 1997), transformation (Oftedal, 1990), and cell survival (Joiner, 1994;Joiner et al, 1996). Joiner et al (2001) showed that most cell lines have hyperradiosensitivity to very low radiation doses, which is not predicted by backextrapolation of the cell survival curve from higher doses.…”

Chromosome Aberrations Induced by Low Doses of X-rays in Human Lymphocytesin Vitro

“…(1972) found no difference in the number of dicentrics in comparison with the control for doses up to 15 rad . Luchnik and Sevankaev (1976) found more dicentrics than expected from extrapolation of the dose-response curve from higher doses of yradiation . However a plateau was observed between 10 and 30 rad .…”

“…Investigations at the low dose range have been performed by Kucerova, Anderson, Buckton and Evans (1972), Lloyd, Purrott, Dolphin, Bolton, Edwards and Corp (1975), Vulpis, Panetta and Tognacci (1976) and Luchnik and Sevankaev (1976) . The data obtained by these authors suggest that the curves described by the quadratic equation are inadequate at the low dose range .…”

Hypothesis regarding a membrane-associated mechanism of biological action due to low-dose ionizing radiation

“…As shown by many authors [29,30,31,32,33], the yield of cytogenetic damage in this dose interval exceeds the level estimated by extrapolation of dose-effect-relationship curves from high doses, whether it is a linear or linear-quadratic dependence (Fig. 4).…”

“…In Zaichkina et al [31], the dose rate of acute irradiation was 0.47 Gy/min and in Aptikaeva et al [37], the dose rate of chronic irradiation was 10 -4 Gy/min, which means that in both cases the dose rate was beyond the effective interval, therefore no repair was initiated and the dose dependence was linear. The dose rate for the adaptive dose in [29] was 0.3 Gy/min.…”