Low Doses of Gamma-Radiation Induce Nonlinear Dose Responses in Mammalian and Plant Cells

Заичкина, С. И.; Rozanova, O. M.; Aptikaeva, G. F.; Achmadieva, A. Ch.; Klokov, Dmitry

doi:10.1080/15401420490519861

Cited by 28 publications

(17 citation statements)

References 19 publications

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“…2d). Such a tri-phasic dose-response has been described by several authors while ascribing the dose-response pattern induced by low LET gamma radiation with respect to micronuclei inductions in Chinese hamster fibroblast cells and Vicia faba root cells, and aberrant cell inductions in barley root cells (Geras kin et al 2003) and human lymphocytes (Zaichkina et al 2004). This complex dose-response pattern is thought to be indicative of the status of DNA repair processes with DNA repair activation being stimulated or triggered by a certain threshold dose or level of DNA damage.…”

Section: Resultsmentioning

confidence: 99%

“…However, the scientific basis for the LNT concept has been challenged over the years as experimental data have shown a non-linear dose-response at low doses (Luchnik 1957, TimofeeffRessovsky andLuchnik 1960). Such non-linear data have led to the recent view that biological effects of ionizing radiation should not be extrapolated from high to low doses based on the LNT model (Zaichkina et al 2004).…”

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confidence: 99%

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Non-Linear Dose Response of a Few Plant Taxa to Acute Gamma Radiation

George¹,

Patel²,

Rane³

et al. 2014

CYTOLOGIA

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SummaryMicronuclei induction serves as an essential biomarker of radiation stress in a living system, and the simplicity of its detection technique has made it a widely used indicator of radiation damage. The present study was conducted to reveal the cytological dose-response of a few plant taxa, viz., Allium cepa var. aggregatum Linn., Allium sativum Linn., Chlorophytum comosum (Thunb.) Jacques and Eichhornia crassipes (Mart.) Solms, to low LET gamma radiation with special emphasis on the pattern of micronuclei induced across low and high dose regimes. A tri-phasic nonlinear dose-response pattern was observed in the four taxa studied, characterised by a low dose linear segment, a plateau and a high dose linear segment. Despite a similar response trend, the critical doses where the phase transitions occurred varied amongst the plant taxa, giving an indication to their relative radiosensitivities. E. crassipes and A. sativum, with their lower critical doses for slope modifications of phase transitions, were concluded as being more radiosensitive as compared to C. comosum and A. cepa, which had relatively higher critical doses.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Non-Linear Dose Response of a Few Plant Taxa to Acute Gamma Radiation

George¹,

Patel²,

Rane³

et al. 2014

CYTOLOGIA

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“…For these reasons, it is recognized worldwide that more research on biological effects of low dose/dose-rate radiation is needed to accurately predict health risks and benefits of low dose/dose-rate radiation. As a consequence, many studies on biological effects of low dose/dose-rate radiation have been conducted under several funding agencies across the world, including the Low Dose Radiation Research Program of the U.S. Department of Energy (Brooks 2015 Results from studies conducted under the low dose programs worldwide have provided evidence of a new paradigm in radiation biology [i.e., a non-linear response curve (Tubiana et al 2009)], as determined by the frequencies of chromosomal damage (Zaichkina et al 2004;Rithidech et al 2012a andb, 2013), cell killing (Aykin-Burns et al 2011), cell transformation (Redpath 2005), mutations (Wickliffe et al 2003), apoptosis (Portess et al 2007), reactive oxygen species (ROS) status of the cells (Feinendegen et al 2004), and cancer (Mitchel et al 2004). Importantly, beneficial (not detrimental) effects of exposure to low doses (≤10 cGy) of radiation have been found (Luckey 1982;Bond et al 1991;Feinendegen 2005;Tubiana et al 2006;Feinendegen et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Health Benefits of Exposure to Low-dose Radiation

Rithidech

2016

Health Physics

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Although there is no doubt that exposure to high doses of radiation (delivered at a high dose-rate) induces harmful effects, the health risks and benefits of exposure to low levels (delivered at a low dose-rate) of toxic agents is still a challenging public health issue. There has been a considerable amount of published data against the linear no-threshold (LNT) model for assessing risk of cancers induced by radiation. The LNT model for risk assessment creates "radiophobia," which is a serious public health issue. It is now time to move forward to a paradigm shift in health risk assessment of low-dose exposure by taking the differences between responses to low and high doses into consideration. Moreover, future research directed toward the identification of mechanisms associated with responses to low-dose radiation is critically needed to fully understand their beneficial effects.

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“…Potentially, non-linear dependencies such as those described for immune modulatory effects after LD-IR, play a role. There are many studies indicating that dose-response curves for LD-IR are non-linear, displaying discontinuous dose dependencies and that they reflect the hypersensitivity of cells to LD-IR not being predictable by extrapolation from the high dose IR response [86][87][88].…”

Section: Effects Of Low Dose (<05 Gy) Irradiation On Normal Stem Cellsmentioning

confidence: 99%