Radiation-associated angiosarcoma: Diagnostic and therapeutic implications—Two case reports and a review of the literature

Cafiero, Ferdinando; Gipponi, Marco; Peressini, A.; Queirolo, Paola; Bertoglio, Sergio; Comandini, Danila; Percivale, Pierluigi; Sertoli, Mario Roberto; Badellino, F

doi:10.1002/(sici)1097-0142(19960615)77:12<2496::aid-cncr12>3.0.co;2-n

Cited by 87 publications

(40 citation statements)

References 31 publications

(2 reference statements)

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“…Secondary angiosarcoma can manifest as either a palpable mass or as just an alteration in skin color (1,6,7). The size and location of palpable masses vary from small cutaneous nodules (the cutaneous subtype) (13) to large lumps that constitute the entire breast (the intraparenchymal subtype).…”

Section: Discussionmentioning

confidence: 99%

“…Results from fine-needle aspiration and punch biopsies are generally not diagnostic and can be misleading because they may resemble those of other entities, such as radiation-related morphea or metastatic breast carcinoma (6,7,13,18). Findings from full-thickness incisional biopsies or excisional biopsy specimens should be conclusive, and these procedures are indicated if angiosarcoma is suspected (4,7,13,18).…”

Section: Discussionmentioning

confidence: 99%

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Angiosarcoma of the Breast

Lim¹,

Goei²

2007

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Angiosarcoma of the Breast

Lim¹,

Goei²

2007

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“…Classical tumor cells reveal the presence of CD31, CD34 and factor VIII (11). In the early stages, epithelioid angiosarcomas are able to metastasize to lymph nodes and parenchymal organs, particularly the lung, bone and soft tissue (1,3). In total, >50% of patients succumb to the disease within 2-3 years of a confirmed diagnosis (4,9).…”

Section: Discussionmentioning

confidence: 99%

“…Angiosarcoma accounts for ~2% of soft tissue sarcomas (1). Epithelioid angiosarcoma is a rare type of angiosarcoma that was first reported by Ng et al in 1996 (2).…”

Section: Introductionmentioning

confidence: 99%

Imaging features of soft tissue epithelioid angiosarcoma in the lower extremity: A case report

Liu

Shi

et al. 2016

Oncology Letters

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Abstract. Epithelioid angiosarcomas are extremely rare malignant tumors formed from endothelial cells. The majority of studies reporting these tumors have been concerned with the clinical and pathological aspects, with limited reporting of radiological diagnosis. The aim of the present study was to provide a reference to improve understanding of diagnosis, treatment choice and prognosis assessment of epithelioid angiosarcoma. The current study reports the case of a 44-year-old woman with epithelioid angiosarcoma located in the deep soft tissue of the lower extremities. Physical examination of the right thigh revealed a palpable hard mass and movement was clearly restricted and painful. X-ray, computed tomography (CT) scans and magnetic resonance imaging (MRI) were used to evaluate the imaging features of the tumor. Using X-ray and CT scanning, an inhomogenous tumor with osteolytic osseous destruction was observed. MRI revealed that the bordering skeletal muscles were infiltrated. The patient was treated with palliative surgery and chemotherapy, but succumbed to disease 1 year later. IntroductionAngiosarcoma accounts for ~2% of soft tissue sarcomas (1). Epithelioid angiosarcoma is a rare type of angiosarcoma that was first reported by Ng et al in 1996 (2). Epithelioid angiosarcoma occurs in various sites, including the skin, head and neck, lungs, breasts, adrenal glands, bones and deep soft tissue in the extremities (3-8). Epithelioid angioma has a male predilection and typically occurs in adults, with the highest incidence being in the seventh decade of life (4). Treatment modalities include surgical resection of the primary tumor, radiation therapy and chemotherapy (4-6). Within 2-3 years of diagnosis, ~50% of patient succumb to disease, however, 20-30% of patients are free of disease (4,9). Advanced age, increased tumor size and a retroperitoneal primary site are considered to be adverse prognostic factors (9). Although pathological examination is the gold standard of diagnosis, radiological studies may provide assistance for determining the treatment choice and assessing the prognosis (10). Magnetic resonance imaging (MRI) reveals the infiltration of the lesion, and computed tomography (CT) angiography (CTA) reveals the involvement of the arteries in the lower extremities, which determines whether or not thrombosis is present (3,4). The current study presents the imaging analysis of a patient with epithelioid angiosarcoma that occurred in the deep soft tissue of the lower extremities. Written informed consent was obtained from the patient. Case reportA 44-year-old woman presented at the Department of Radiology, The Affiliated Hospital of Xuzhou Medical College (Jiangsu, China) on September 16, 2012 with soreness in the medial side of the right thigh, which had developed over 2 months. Almost 1 month later, a mass had evolved at the painful site; however, the pain was not associated with exertion. A physical examination revealed an increased temperature on the medial side, at the mid-shaft of the femur. The ma...

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“…T he rarity of these cases was such that no change in the current policy of conservative therapy with radiotherapy for breast cancer was advocated. 32 Angiosarcom as of the breast or overlying skin are now the m ost com m on sarcom a following breast conservation treatment, 37 and have a better prognosis than the other types of sarcom a, with m ost cases cured by m astectom y, particularly if they are diagnosed early. M alignant ® brous histiocytomas and ® brosarcom as have also been reported.…”

Section: B Reast Cancermentioning

confidence: 99%

Should Cancer Survivors Fear Radiation‐Induced Sarcomas?

Feigen

1997

Sarcoma

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A bstractPurpose/Results. Ionizing radiation is carcinogenic and the induction of a second malignancy is a serious potential long-term complication of radiotherapy. The incidence of radiation-induced sarcomas was evaluated from many large epidemiological surveys of long-term cancer survivors reported in the literature over the past 30 years and only one case was found for every 1000 patients irradiated. D iscussion. Although greater numbers of cancer patients are receiving radical radiotherapy and surviving free of disease for longer intervals, cases of radiation-induced sarcomas are rare and should not deter patients from accepting radiotherapy as treatment for curable cancers. With improvements in the administration of radiotherapy over the past two decades which are resulting in less damage to bone and soft tissues, it is likely that fewer cases of this condition will be seen in the future. If these sarcomas are diagnosed early, long-term survival can be achieved with surgical excision and possibly re-irradiation, as occurs in other types of sarcomas.K ey w ords: radiation-induced sarcoma, bone sarcom a, soft tissue sarcom a.

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Radiation-associated angiosarcoma: Diagnostic and therapeutic implications—Two case reports and a review of the literature

Abstract: BACKGROUND. Angiosarcoma (AS) accounts for 1 to 2% of all soft tissue sarcoma.

Cited by 87 publications

References 31 publications

Angiosarcoma of the Breast

Angiosarcoma of the Breast

Imaging features of soft tissue epithelioid angiosarcoma in the lower extremity: A case report

Should Cancer Survivors Fear Radiation‐Induced Sarcomas?

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