Rabies: Still a silent killer targeting the poor

Wilde, Henry; Ghai, Siriporn; Hemachudha, Thiravat

doi:10.1016/j.vaccine.2017.03.001

Cited by 14 publications

(14 citation statements)

References 4 publications

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“…8,9 Health service inequalities remain at the heart of the rabies problem, with poorer and typically rural communities not enjoying good access to veterinary and human health services being the most vulnerable. 8,10,11,12 Further compounding the problem is the lack of accurate surveillance statistics that could bolster the support for rabies control and prevention programmes in the affected country. 11,12,13,14 Apart from the loss of human life, the cost of the provision of rabies PEP to prevent rabies infection in humans where dog rabies endemically occurs presents a significant economic burden.…”

Section: Introductionmentioning

confidence: 99%

“…8,10,11,12 Further compounding the problem is the lack of accurate surveillance statistics that could bolster the support for rabies control and prevention programmes in the affected country. 11,12,13,14 Apart from the loss of human life, the cost of the provision of rabies PEP to prevent rabies infection in humans where dog rabies endemically occurs presents a significant economic burden. 8,12 The global annual expenditure for rabies PEP biologicals and delivery of the treatment has been estimated to be $8.6 billion.…”

Section: Introductionmentioning

confidence: 99%

“…11,12,13,14 Apart from the loss of human life, the cost of the provision of rabies PEP to prevent rabies infection in humans where dog rabies endemically occurs presents a significant economic burden. 8,12 The global annual expenditure for rabies PEP biologicals and delivery of the treatment has been estimated to be $8.6 billion. 8 Background: Rabies is an untreatable and highly fatal viral zoonosis.…”

Section: Introductionmentioning

confidence: 99%

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A dog bite study in a dog rabies-affected area in South Africa

Weyer¹,

Roux

Kajese

et al. 2020

Southern African Journal of Infectious Diseases

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Background: Rabies is an untreatable and highly fatal viral zoonosis. Despite the ability to control and prevent the disease, it is estimated that one person dies of rabies every 10 minutes in developing countries. However, the true burden of the disease remains undefined in most developing countries because of a lack of systematic surveillance. Dog bite data obtained from healthcare facilities where dog bite victims seek medical care may provide an additional source of information that can be used to inform the burden of disease and identify points for interventions for improved delivery of post-exposure prophylaxis (PEP) to prevent the disease.Methods: A descriptive epidemiological study was conducted using data obtained from dog bite registers and patient case files at a healthcare facility for a two year period (2015-2017).Results: The study reported frequency, demographics, source, geographic and temporal distribution of bite cases reported to a hospital serving a rabies-affected community. In addition, the post-exposure management of dog bite cases at this facility is described.Conclusion: Dog bites was not an infrequently reported at the healthcare facility, with up to 29 cases reported in a month during the study period. The affected population was defined and it is motivated that this information is useful for targeted health interventions. Findings related to the delivery of PEP may also be used to direct training and re-training of healthcare workers for improved delivery of PEP.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A dog bite study in a dog rabies-affected area in South Africa

Weyer¹,

Roux

Kajese

et al. 2020

Southern African Journal of Infectious Diseases

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“…As bullet-shaped, single-stranded, negative-sense RNA virus, rabies virus is the causative agent of the ancient zoonosis rabies known to cause acute encephalomyelitis, and is almost universally fatal in unimmunized patients [2]. The total number of reported human rabies deaths by WHO have been mostly estimates, varying between 40,000 to 60,000 cases annually over the past 3-4 decades [1]. The majority of deaths are caused by unvaccinated dogs, and often in poor and remote regions, where post exposure rabies prophylaxis is neither readily available nor affordable [3].…”

Section: Discussionmentioning

confidence: 99%

“…Encephalitis and neurological signs are iconic symptoms of rabies [1]. Coronary artery disease has become so common that anyone with the complaint of chest discomfort is suspected.…”

Section: Introductionmentioning

confidence: 99%

Rabies in coronary care unit: a case report

Liu¹,

Yang²,

Yang³

2018

biomedicalresearch

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Rabies features encephalitis and neurological symptoms. Although its clinical course can be prolonged by life support measures, its fatal outcome is virtually inevitable. Coronary artery disease has become so common that anyone complaining of chest discomfort is suspected. Despite the fact that rabies encephalitis is often complicated with heart impairment or myocarditis, it can still be ignored when cardiac symptoms like chest discomfort or shortness of breath act as chief complaints. This case report demonstrates a rabies patient presenting with conditions similar to acute coronary syndrome; he even underwent coronary angiography. He was the only rabies patient admitted by cardiologists in our hospital. This case reminded us that some unusual cause of cardiac manifestations needs to be considered during daily management of chest discomfort.

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