R-carrying genotypes of serum paraoxonase (PON1) 192 polymorphism and higher activity ratio are related to susceptibility against ischemic stroke

Mahrooz, Abdolkarim; Gohari, Ghorban; Hashemi, Mohammad Hassan; Zargari, Mehryar; Musavi, Hadis; Alameddine, Mahmoud; Alizadeh, Ahad

doi:10.1007/s11033-012-2027-8

Cited by 20 publications

(14 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…67 Their results are in agreement with the previous work by Liu et al; 21 the presence of the 192 R allele potentiates the risk of stroke, especially in hypertensive subjects. They also found that patients had a significantly higher paraoxon/arylesterase ratio than control subjects and in stroke patients paraoxon/ arylesterase and paraoxon/HDL ratios followed this pattern: QQ < QR < RR.…”

Section: Pon1 and Ischemic Strokesupporting

confidence: 91%

“…They suggest that the ratio of para/aryl, para/HDL and aryl/HDL ratios may prove useful as markers for an augmented predisposition to ischemic stroke. 67 In 2011, Michalak et al studied the association of PON1 triesterase ( paraoxon) and arylesterase activities and conjugated dienes on stroke patient outcome during a 1-year follow-up period. 68 They concluded that the PON/aryl ratio is a significant predictor of ischemic stroke outcome and could be used in the clinical setting to better advantage than the paraoxon or aryl assays alone.…”

Section: Pon1 and Ischemic Strokementioning

confidence: 99%

See 1 more Smart Citation

Paraoxonase 1 in neurological disorders

Menini

Gugliucci

2013

Redox Report

View full text Add to dashboard Cite

Paroxonase 1 displays multiple physiological activities that position it as a putative player in the pathogenesis of neurological disorders. Here we reviewed the literature focusing on the role of paraoxonase 1 (PON1) as a factor in the risk of stroke and the major neurodegenerative diseases. PON1 activity is reduced in stroke patients, which significantly correlates inversely with carotid and cerebral atherosclerosis. The presence of the R allele of the Q192R PON1 polymorphism seems to potentiate this risk for stroke. PON1 exerts peroxidase activities that may be important in neurodegenerative disorders associated with oxidative stress. PON1 is also a key detoxifier of organophosphates and organophosphate exposure has been linked to the development of neurological disorders in which acetylcholine plays a significant role. In Parkinson's disease most of the studies suggest no participation of either L55M or the Q192R polymorphisms in its pathogenesis. However, many studies suggest that the MM55 PON1 genotype is associated with a higher risk for Parkinson's disease in individuals exposed to organophosphates. In Alzheimer's disease most studies have failed to find any association between PON1 polymorphisms and the development of the disease. Some studies show that PON1 activity is decreased in patients with Alzheimer's disease or other dementias, suggesting a possible protective role of PON1. No links between PON1 polymorphisms or activity have been found in other neurodegenerative diseases such as multiple sclerosis and amyotrophic lateral sclerosis. PON1 is a potential player in the pathogenesis of several neurological disorders. More research is warranted to ascertain the precise pathogenic links and the prognostic value of its measurement in neurological patients.

show abstract

Section: Pon1 and Ischemic Strokesupporting

confidence: 91%

Section: Pon1 and Ischemic Strokementioning

confidence: 99%

Paraoxonase 1 in neurological disorders

Menini

Gugliucci

2013

Redox Report

View full text Add to dashboard Cite

show abstract

“…Several studies suggest that a low-level plasma PON-1 activity is associated with increased prevalence of atherosclerosis and could be an independent risk factor for coronary events [12, 39]. …”

Section: Discussionmentioning

confidence: 99%

Grape Polyphenols Increase the Activity of HDL Enzymes in Old and Obese Rats

Zagayko

Kravchenko

Krasilnikova

et al. 2013

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

HDL particles are protein-rich particles that act as a vehicle for reverse cholesterol transport from tissues to the liver. The purpose of this study was to investigate age-dependent changes in the functional activity of HDL and the effect of high-energy diet on this index, as well as to correct it under the influence of grape polyphenols from “Enoant” obtained from Vitis vinifera grapes. We observed the age-dependent composition changes in HDL particle. It was shown that total lipids and triacylglycerol (TG) levels were higher in 24-month-old animals. In obese rats, HDL total lipids and TG levels were higher in 24-month-old than in the 3-month-old and 12-month-old groups but did not differ from 24-month-old group. The plasma HDL paraoxonase (PON) and lecithin:cholesterol acyltransferase (LCAT) activity levels were decreased in old-aged rats, and cholesteryl ester transfer protein (CETP) activity was higher in old rats. Keeping 12-month-old animals on high-fructose diet completely leveled the age differences in the data that have been measured between 12-month-old and 24-month-old rats. After “Enoant” administration, an increase of HDL PON and LCAT activity levels and a reduction of CETP activity were found in 24-month-old and obese rats.

show abstract

“…The association between PON1 and ischemic stroke has been investigated in several previous studies [ 18 , 19 , 24 , 25 , 26 , 27 ]. For example, a meta-analysis including 7384 cases and 11,074 controls, showed that PON1 rs662_G was positively associated with risk of IS with summary OR (95% CI) of 1.10 (1.04–1.17) [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Joint Effects of PON1 Polymorphisms and Vegetable Intake on Ischemic Stroke: A Family-Based Case Control Study

Juan

Jiang

Tang

et al. 2017

IJMS

View full text Add to dashboard Cite

Paraoxonase 1 gene (PON1) polymorphisms and dietary vegetable and fruit intake are both established determinants of ischemic stroke (IS). However, little is known about whether these factors jointly influence the risk of IS. We analyzed the main effects of PON1, as well as the interactions between PON1 and dietary vegetable or fruit intake with the risk of total IS and its subtypes in a family-based case-control study conducted among 2158 Chinese participants (1007 IS cases and 1151 IS-free controls) from 918 families. Conditional logistic regression models, with each family as a stratum, were used to examine the association between rs662 and IS. Gene-diet interactions were tested by including a cross-product term of dietary vegetable or fruit intake by rs662_G allele count in the models. Each copy of the PON1 rs662_G allele was associated with 28% higher risk of total IS (p = 0.008) and 32% higher risk of large artery atherosclerosis subtype (LAA) (p = 0.01). We observed an interaction between rs662 and vegetable intake for both total IS (p = 0.006) and LAA (p = 0.02) after adjustment for covariates. Individuals who carry the rs662_A allele may benefit to a greater extent from intake of vegetables and thus be more effectively protected from ischemic stroke, whereas carriers of the G allele may still remain at greater risk for ischemic stroke due to their genetic backgrounds even when they consume a high level of vegetables. More studies are needed to replicate our findings among other populations.

show abstract

R-carrying genotypes of serum paraoxonase (PON1) 192 polymorphism and higher activity ratio are related to susceptibility against ischemic stroke

Cited by 20 publications

References 36 publications

Paraoxonase 1 in neurological disorders

Paraoxonase 1 in neurological disorders

Grape Polyphenols Increase the Activity of HDL Enzymes in Old and Obese Rats

Joint Effects of PON1 Polymorphisms and Vegetable Intake on Ischemic Stroke: A Family-Based Case Control Study

Contact Info

Product

Resources

About