Grape Polyphenols Increase the Activity of HDL Enzymes in Old and Obese Rats

Zagayko, A. L.; Kravchenko, Ganna; Krasilnikova, O. A.; Ogai, Yuri O.

doi:10.1155/2013/593761

Cited by 20 publications

(28 citation statements)

References 38 publications

(43 reference statements)

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“…This effect was reasoned to the increase in HDL paraoxonase HDL PON that leads to increasing the cellular response via the increase in the receptors (20). HDL increasing is linked to the generation of is oflavone genistein by polyphenols that leads to activation of protein kinase mitogen (21). In the case of glucose, our study shows a significant decrease in G3 when compared to G2 and G1 at 21 and 42 day of age.…”

Section: Discussionmentioning

confidence: 52%

Effect of supplementation of red grape pomace in ration on some blood traits of broiler

Al-Mihna¹

2017

QJVMS

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This study was conducted in the animal field of Veterinary Medicine College / University of Al-Qadisiyah., The trial lasted 42 days between 2016/10/19 -2016 for the purpose of knowing the effect of adding grape pomace (GP) to the ration on some blood characteristics of broilers. In the study, 150 chicks (Ross-308) were randomized to three groups (50 chicks) for each group (25 replicates). The first group was the control treatment (G1) that was given no food additive. The second group was (G2) and was given 25 g of GP / kg of ration along experiment duration. The third treatment (G3) was given 50 g GP / kg of ration throughout the experiment period. The results showed decreases in the level of cholesterol both in G2 and G3 compared to G1 (P≤ 0.05). There was also a significant improvement in the level of triglycerides in G3 (P≤ 0.05) at age 21 days, while there was a significant improvement in these lipids in G2 and G3 (P≤ 0.05) at age 42 days. The results showed a significant decrease (P≤ 0.05) in the LDL of G2 and G3 at 21 days of age plus a significant decrease in G3 at 42 days of age. The results also showed a significant increase (P≤ 0.05) in the HDL of G2. G3 overran G1 and G1+ G2 at the age of 21 and 42 days respectively. The results revealed a significant decrease (P≤ 0.05) in glucose level of G3 at age 21 days and 42 days. G2 showed significant difference at age 21 days and no significant difference at age 42. In conclusion, the grape pomace in ( 2.5% or 5% ) of broiler ration leads to improve the performance traits, health benefits and some of the blood parameters in broilers, the traits that we used are considered as health indicators, growth promoters, production and performance effectors.

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Section: Discussionmentioning

confidence: 52%

Effect of supplementation of red grape pomace in ration on some blood traits of broiler

Al-Mihna¹

2017

QJVMS

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“…Our research group found a positive association with a strong increase of HDL after G8000 intake. Zagayko et al (2013) observed a reduction of cholesterol ester transfer protein (CETP) and an increase of HDL enzymes activity in rats after 21 days of grape polyphenol concentrate. These findings are in good agreement with our results.…”

Section: Discussionmentioning

confidence: 99%

Novel natural food colourant G8000 benefits LDL- and HDL-cholesterol in humans

Peres

Gollucke

Soares

et al. 2015

International Journal of Food Sciences and Nutrition

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The aim of this study was to investigate the phenolic composition of a natural food colourant (G8000™) as well as its effects on plasma markers after 28-day consumption by healthy individuals at a dietary dose (70 g). Parameters of total cholesterol and its fractions, triglycerides and plasma enzymes biomarkers of muscle injury were measured. Major compounds identified in G8000™ by ESI-MS showed the presence of anthocyanins, organic acids, phenolic acids as well as monosaccharides. HDL levels significantly increased from 43 ± 10.2 mg/dL to 95 ± 16.9 mg/dL. LDL levels significantly decreased from 110 ± 40.9 mg/dL to 69 ± 39 mg/dL (p < 0.001). No significant statistical differences (p > 0.05) were observed for total cholesterol, triglycerides and VLDL. After the intake, plasma enzyme CK-MB decreased from 20 ± 12.1 U/L to 10 ± 1.9 U/L while LDH levels increased from 275 ± 124.4 U/L to 317 ± 114.7 U/L (p < 0.005). No significant differences were observed for CK levels. Taken together, dietary intake of natural colourant G8000™ was able to exert beneficial effects on atherosclerosis biomarkers.

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“…Another aspect that should be considered is the age of participants cited in the studies. Although there is no evidence in the literature demonstrating the effects of age in response to grape juice consumption on memory and other clinical-functional outcomes, it has been reported in experimental findings that the consumption of polyphenols acts in an agedependent manner in some biomarkers, which could affect some clinical data [44]. Then, these results led us to infer that the age and time of grape juice consumption might be strictly related to its impact on memory performance.…”

Section: Sift Deskmentioning

confidence: 91%

Grape juice consumption and/or exercise training-induced neuroplasticity and memory improvement in healthy elderly women

Elsner¹,

Trevizol²,

Bassôa³

et al. 2018

SDRP-JCMP

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Background: Emerging evidences have been pointed out that exercise in combination with dietary factors is able to affect molecular events related to synaptic plasticity and cognitive improvement. Therefore, this study sought to verify the impact of grape juice consumption and/or exercise in plasma neurotrophic factor (BDNF) levels and memory performance in elderly women. Methods: Nineteen healthy elderly women were randomly distributed in two groups: Grape Juice Group (GJG, n=9) and Grape Juice + Exercise Group (GJEG, n=10). The GJG was instructed to drunk daily the grape juice (400 ml) for 30 days, while the GJEG was also submitted to a physical exercise intervention (twice a week, 60 min/session). Memory function was assessed via the MoCA (Montreal Cognitive Assessment) and blood sampling was taken for BDNF analysis pre/post intervention in both groups. Results: It was observed a significant increase on BDNF levels in GJG (p=0.000) and GJEG (p=0.041) after intervention, while the memory improvement was verified only in GJEG (p=0.024). No differences between groups were found in the variables. Conclusion: In conclusion, the grape juice consumption per se is capable to modulates/increases BDNF levels, response that was not potentiated by exercise practice. On the other hand, the memory performance was improved only when grape juice consumption is combined to exercise intervention in healthy elderly women.

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Grape Polyphenols Increase the Activity of HDL Enzymes in Old and Obese Rats

Cited by 20 publications

References 38 publications

Effect of supplementation of red grape pomace in ration on some blood traits of broiler

Effect of supplementation of red grape pomace in ration on some blood traits of broiler

Novel natural food colourant G8000 benefits LDL- and HDL-cholesterol in humans

Grape juice consumption and/or exercise training-induced neuroplasticity and memory improvement in healthy elderly women

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