Quimioterapia da doença de Chagas: estado da arte e perspectivas no desenvolvimento de novos fármacos

Dias, Luiz C.; Dessoy, Marco A.; Silva, Jean Jerley N.; Thiemann, Otávio Henrique; Oliva, Glaucius; Andricopulo, Adriano D.

doi:10.1590/s0100-40422009000900038

Cited by 94 publications

(126 citation statements)

References 49 publications

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“…35 The ICBG assembles academic expertise in the field of NTDs in Brazil with experience in partnership with Drugs for Neglected Diseases Initiative (DNDi). 36,37 Screening natural products has special advantages for parasitic diseases, as well as other infectious and cancer, since the remarkable structural diversity of natural products can represent potential source of novel pharmacophores. 38 …”

Section: The Need For Antifungal Anticancer and Antiprotozoal Agentsmentioning

confidence: 99%

Microbial Symbionts of Insects are the Focus of the First International Cooperative Biodiversity Group (ICBG) in Brazil

Pupo¹,

Currie²,

Clardy³

2016

J. Braz. Chem. Soc.

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The basic aim of the ICBG (International Cooperative Biodiversity Group) program is to benefit both the host country and the global scientific community by discovering and developing new solutions to human health problems based on previously unexplored genetic resources. The first ICBG in Brazil is jointly supported by the Fogarty International Center of the National Institutes of Health (FIC/NIH) in the USA and by the São Paulo Research Foundation (FAPESP) in Brazil. The ongoing ICBG, developed under the BIOTA-FAPESP Program, is based on the highly evolved fungus-growing ant multilateral symbiosis between three mutualists and one parasite. The project aligns chemical ecology and therapeutic application, increasing the chances of discovering new antifungal, antibacterial, anticancer and antiprotozoal hits and leads. In this article we describe the rationale of the ICBG and the legal requirements to develop this type of international collaborative project in Brazil.

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Section: The Need For Antifungal Anticancer and Antiprotozoal Agentsmentioning

confidence: 99%

Microbial Symbionts of Insects are the Focus of the First International Cooperative Biodiversity Group (ICBG) in Brazil

Pupo¹,

Currie²,

Clardy³

2016

J. Braz. Chem. Soc.

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“…Chagas disease is an infectious process caused by the protozoan Trypanosoma cruzi, which in turn is transmitted to humans through triatomine insects commonly known as "barbers" [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Computational study of aromatic compounds inhibiting<em> Trypanosoma cruzi</em> glyceraldehyde 3-phosphate dehydrogenase

Delmondes

Moraes

Stefani

2017

Proceedings of MOL2NET 2017, International Conference on Multidisciplinary Sciences, 3rd Edition

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Chagas disease is caused by the protozoan Trypanosoma cruzi and is widely distributed throughout Latin America. Because it is a pathology neglected by the pharmaceutical industry and because existing drugs have low efficacy and several side effects, interest in new drugs has been increasing. Due to the necessity of the discovery of new structures, the objective of this work was to relate the biological activity of natural and semi-synthetic aromatic compounds, inhibitors of glyceraldehyde 3-phosphate dehydrogenase enzyme, with descriptors calculated by molecular modeling, such as HOMO-LUMO frontier orbitals, partition coefficient (LogP) and water solubility (LogS), in addition to performing a molecular docking study, in order to obtain a better molecular view of the interaction of the aromatic compounds with the active site of the enzyme. It was observed that the compounds involved in the study interacted attractively with the enzyme, in accordance with experimental studies, and had adequate solubility for good pharmacokinetics. It was also possible to relate the pharmacological activity of some compounds with the energy of the LUMO orbital. The study showed that the methodology used in this work can be used to understand the interaction of active compounds with their respective targets, saving time and resources. __________________________________________________________________________________ Keywords: Chagas disease, molecular docking, molecular modeling, aromatic compounds Graphical Abstract:MOL2NET, 2017, 3, http://sciforum.net/conference/mol2net-03 2 Introduction:

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“…A maioria dos pacientes se encontra na fase aguda e possui aparência saudável, não havendo evidências de danos aos órgãos. Essa fase é seguida pela fase crônica, que se inicia à medida que os níveis de parasitemia diminuem em intensidade (WHO, 2000;DIAS et al, 2009).…”

Section: Doenças Negligenciadasunclassified

“…No entanto, 20 a 30% dos indivíduos infectados irão para a próxima etapa, na qual desenvolverão complicações apresentadas na forma de lesões em vários órgãos. O coração e o sistema digestivo são os principais órgãos atingidos, e, sendo assim, a referida condição será denominada forma cardíaca, quando atingir o coração, e forma digestiva, quando atingir o sistema digestivo (WHO, 2000(WHO, , 2012bDIAS et al, 2009).…”

Section: Doenças Negligenciadasunclassified

Candidatos a leishmanicidas, antichagásicos e tuberculostáticos: estudo da síntese de fármacos dirigidos de hidroximetilnitrofural com manana para liberação específica em macrófagos

Primi¹

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Quimioterapia da doença de Chagas: estado da arte e perspectivas no desenvolvimento de novos fármacos

Cited by 94 publications

References 49 publications

Microbial Symbionts of Insects are the Focus of the First International Cooperative Biodiversity Group (ICBG) in Brazil

Microbial Symbionts of Insects are the Focus of the First International Cooperative Biodiversity Group (ICBG) in Brazil

Computational study of aromatic compounds inhibiting<em> Trypanosoma cruzi</em> glyceraldehyde 3-phosphate dehydrogenase

Candidatos a leishmanicidas, antichagásicos e tuberculostáticos: estudo da síntese de fármacos dirigidos de hidroximetilnitrofural com manana para liberação específica em macrófagos

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