Quercitrin protects against ultraviolet B-induced cell death in vitro and in an in vivo zebrafish model

Yang, Hye-Won; Ham, Young-Min; Yoon, Weon‐Jong; Roh, Seong Woon; Jeon, You‐Jin; Oda, Tatsuya; Kang, Sung-Myung; Kang, Min‐Cheol; Kim, Eun-A; Kim, Daekyung; Kim, Kil-Nam

doi:10.1016/j.jphotobiol.2012.05.020

Cited by 58 publications

(43 citation statements)

References 36 publications

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“…Daily flavonoid intake (typically present in onion, apple, grape, wine, herbs, and spices) in the human diet is highly variable, with estimations ranging from 23 mg/day to more than 500 mg/day (Felgines et al, 2000; Hertog et al, 1993). Flavonoids are efficient antioxidants that scavenge oxygen radicals and possess anticancer, hypolipidemic, anti-aging, and anti-inflammatory activities (Yang et al, 2012). These biological activities exerted by flavonoids are mainly attributed to their antioxidant properties (Hollman et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Quercitrin protects skin from UVB-induced oxidative damage

Yin

Son

et al. 2013

Toxicology and Applied Pharmacology

142

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Exposure of the skin to ultraviolet B (UVB) radiation causes oxidative damage to skin, resulting in sunburn, photoaging, and skin cancer. It is generally believed that the skin damage induced by UV irradiation is a consequence of generation of reactive oxygen species (ROS). Recently, there is an increased interest in the use of natural products as chemopreventive agents for non-melanoma skin cancer (NMSC) due to their antioxidants and anti-inflammatory properties. Quercitrin, glycosylated form of quercetin, is the most common flavonoid in nature with antioxidant properties. The present study investigated the possible beneficial effects of quercitrin to inhibit UVB irradiation-induced oxidative damage in vitro and in vivo. Our results showed that quercitrin decreased ROS generation induced by UVB irradiation in JB6 cells. Quercitrin restored catalase expression and GSH/GSSG ratio reduced by UVB exposure, two major antioxidant enzymes, leading to reductions of oxidative DNA damage and apoptosis and protection of the skin from inflammation caused by UVB exposure. The present study demonstrated that quercitrin functions as an antioxidant against UVB irradiation-induced oxidative damage to skin.

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Section: Introductionmentioning

confidence: 99%

Quercitrin protects skin from UVB-induced oxidative damage

Yin

Son

et al. 2013

Toxicology and Applied Pharmacology

142

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“…short life span, comparatively small size, and similarity to mammals (Ko et al 2011). Zebrafish have previously been used in several studies as an in vivo model for UV protective research (Dong et al 2007, Ko et al 2011, Yang et al 2012). Hence, we selected zebrafish as an in vivo model to investigate the UVB protective effect of Spirogyra sp.…”

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confidence: 99%

Protective effect of gallic acid derivatives from the freshwater green alga Spirogyra sp. against ultraviolet B-induced apoptosis through reactive oxygen species clearance in human keratinocytes and zebrafish

Wang¹,

Ryu²,

Kim³

et al. 2017

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“…Authors like Yasin et al () consider that antioxidant supplementation improves the meat quality and, if antioxidants accumulate in edible tissues, they render a food with functional characteristics. In aquatic organisms, the use of antioxidants like lipoic acid or quercetin improves the nutritional value of aquaculture products and renders the organisms more resilient to stress conditions, common in aquaculture practice as hypoxia followed by reoxigenation (Martins et al, ; Shin, Yoo, Min, Lee, & Choi, ; Yang et al, ). In this way, the increment of total flavonoids levels in shrimp, particularly in muscle (Figure ) can be considered as the acquisition of functional properties.…”

Section: Discussionmentioning

confidence: 99%

“…The higher antioxidant content found mainly in muscle of L. vannamei cannot be considered only in terms of food of better quality and functional properties for human consumption but also for the animal welfare itself. Higher antioxidant competence augments animal resilience against pro‐oxidant insults and exposure to toxic molecules (Monserrat et al, ; Yang et al, ). Martins et al () found that diets for L. vannamei supplemented with lipoic acid prevented the loss of antioxidant competence in gills after a condition of hypoxia/reoxygenation.…”

Section: Discussionmentioning

confidence: 99%

“…In fish species, quercetin supplementation showed to improve both antioxidant and zootechnical parameters in tilapia (Zhai and Liu, ) and ameliorated the pro‐oxidant effects induced by antibiotics in silver catfish (Pês et al, ). In zebrafish Danio rerio cells, treatment with quercetin was efficient in the reduction in ROS generation after ultraviolet radiation (280–315 nm: UVB) exposure (Yang et al, ).…”

Section: Introductionmentioning

confidence: 99%

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Quercetin influence in water quality and biochemical responses of shrimpLitopenaeus vannameireared in Biofloc Technology System

2018

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Biofloc Technology System (BFT) is a rearing method that uses microorganism communities to preserve water quality and improves several biological parameters of Pacific white shrimp Litopenaeus vannamei. The water of a BFT system received four different concentrations of the antioxidant quercetin every 24 hr plus a control treatment, without adding quercetin. During 7 days, several water quality parameters were analysed daily. Results indicated that all parameters remained in the optimal range for L. vannamei. In a second experiment, shrimps were maintained in a BFT system with (1 mg/L) or without quercetin addition during 30 days. At the end of the experimental period, it was measured total flavonoids content and lipid peroxidation in muscle and hepatopancreas of shrimps. The results indicated that: (a) flavonoid content in muscle and hepatopancreas of shrimps increased after 10 and 20 days of quercetin treatment, respectively; (b) lipid peroxidation was reduced in both organs after antioxidant treatment; (c) weight gain was improved in quercetinsupplemented shrimps. It is concluded that bioflocs of BFT systems treated with quercetin increased their antioxidant capacity without changing water quality parameters for the appropriate development of shrimp culture and improved growth and reduced the oxidative damage of reared organisms. K E Y W O R D S antioxidant supplements, BFT, flavonoids, functional food, water quality

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Quercitrin protects against ultraviolet B-induced cell death in vitro and in an in vivo zebrafish model

Cited by 58 publications

References 36 publications

Quercitrin protects skin from UVB-induced oxidative damage

Quercitrin protects skin from UVB-induced oxidative damage

Protective effect of gallic acid derivatives from the freshwater green alga Spirogyra sp. against ultraviolet B-induced apoptosis through reactive oxygen species clearance in human keratinocytes and zebrafish

Quercetin influence in water quality and biochemical responses of shrimpLitopenaeus vannameireared in Biofloc Technology System

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