Quercitrin protects skin from UVB-induced oxidative damage

Abstract

Exposure of the skin to ultraviolet B (UVB) radiation causes oxidative damage to skin, resulting in sunburn, photoaging, and skin cancer. It is generally believed that the skin damage induced by UV irradiation is a consequence of generation of reactive oxygen species (ROS). Recently, there is an increased interest in the use of natural products as chemopreventive agents for non-melanoma skin cancer (NMSC) due to their antioxidants and anti-inflammatory properties. Quercitrin, glycosylated form of quercetin, is the most common flavonoid in nature with antioxidant properties. The present study investigated the possible beneficial effects of quercitrin to inhibit UVB irradiation-induced oxidative damage in vitro and in vivo. Our results showed that quercitrin decreased ROS generation induced by UVB irradiation in JB6 cells. Quercitrin restored catalase expression and GSH/GSSG ratio reduced by UVB exposure, two major antioxidant enzymes, leading to reductions of oxidative DNA damage and apoptosis and protection of the skin from inflammation caused by UVB exposure. The present study demonstrated that quercitrin functions as an antioxidant against UVB irradiation-induced oxidative damage to skin.

Pimpinella alpina Molk Administration is Capable of Increasing Antioxidant and Decreasing Prooxidant Level following UVB Irradiation

“…These results demonstrated that PaM administration during 15 days in rats was capable of increasing activity of antioxidant SOD and CAT much better rather than 7 days administration. This result was similar with the quercetine administration in mice during 7 days compared with 1 day 50 . Correlation test between SOD activity and MDA concentration as well as SOD and 8OHdG with Pearson methods on each group displayed a strong negative correlation (-0.931 and -0.913; p < 0.001) respectively.…”

“…A study reported that UVB irradiation on cells induced dramatic depletion of GSH and therefore caused a decrease in GSH/GSSG ratio. Quercetine restored the GSH depletion back to control level 50 . The result of the present study was in alignment with the previous studies.…”

“…This was in contrast to CAT activity, which was already absent in the limbal region after the 4 days UVB irradiation procedure 34 . The decrease in SOD and CAT following UVB irradiation is probably induced by reducing GSH/GSSG ratio 35 .…”

Hydroalcoholic Extract from Copaifera Langsdorffii Has Skin Wound Healing Activity in Rats

“…The HPLC chromatographic analyses allowed the identification of two major phenolic compounds, quercetin-3-O-a-L-rhamnopyranoside (quercitrin) and kaempferol-3-O-a-L-rhamnopyranoside (afzelin) in hydroalcoholic extract of Copaifera langsdorffii leaves. Quercitrin and afzelin are glycosides of quercetin which have shown antioxidant [26], anti-inflammatory [27] activities and protection against UV-damage [28,29]. By the biological properties of these phenolic compounds, the skin wound healing capacity may be related with the presence of the two major flavonoids in the extract.…”

Genetic analysis of the human hair roots as a tool for spaceflight experiments

“…In addition, Yin et al also suggested that DNA damage was induced in the mouse skin upon exposure to ultraviolet radiation [48]. These results suggested that the skin, which contains hair follicles, receive the effects on gene condition by physiological changes or extraordinary environments.…”