Quercetin nanoparticles induced autophagy and apoptosis through AKT/ERK/Caspase-3 signaling pathway in human neuroglioma cells: In vitro and in vivo

Lou, Miao; Zhang, Lina; Ji, Peigang; Feng, Fuqiang; Liu, Jinghui; Yang, Chen; Li, Bao-fu; Wang, Liang

doi:10.1016/j.biopha.2016.08.055

Cited by 107 publications

(55 citation statements)

References 41 publications

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“…14 Recent researches affirm that drug delivery via nanoparticles can improve efficacy with decreasing side effects. 15 In this regard, poly(ethylene glycol)-block-(poly(ethylenediamine l-glutamate)-graft-poly(ε-benzyloxycarbonyll-lysine)) (PEG-b-(PELG-g-PZLL)) is synthesized and QUE/PEG-b-(PELG-g-PZLL) (QUE/P) nanoparticle complex is measured in vitro and vivo.…”

Section: Introductionmentioning

confidence: 99%

Quercetin nanoparticle complex attenuated diabetic nephropathy via regulating the expression level of ICAM-1 on endothelium

Tong¹,

Liu²,

Yan³

et al. 2017

IJN

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The purpose of the study was to reveal the therapeutic effect of quercetin (QUE) nanoparticle complex on diabetic nephropathy (DN) by regulating the expression of intercellular adhesion molecular-1 (ICAM-1) on endothelium as compared to free QUE. QUE 10 mg/kg as a single abdominal subcutaneous injection daily for 8 weeks continuously in diabetic rats and 10 mg/kg QUE nanoparticle complex as a single abdominal subcutaneous injection every 5 days, continuously administered for 8 weeks to diabetic rats. Blood and left kidneys were collected; pathological change of kidney, renal function, oxidative stress level, blood glucose level, serum lipid, urine protein, and albumin/creatinine ratio were measured; and neutrophil adhesion, ICAM-1 expression, and CD11b + cells infiltration were observed. Both QUE and QUE nanoparticle complex preconditioning ameliorated the pathological damage of kidney and improved renal function, alleviated renal oxidative stress injury, restricted inflammatory cells infiltration, and downregulated the ICAM-1 expression as compared to DN group, while QUE nanoparticle complex significantly alleviated this effect.

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Section: Introductionmentioning

confidence: 99%

Quercetin nanoparticle complex attenuated diabetic nephropathy via regulating the expression level of ICAM-1 on endothelium

Tong¹,

Liu²,

Yan³

et al. 2017

IJN

View full text Add to dashboard Cite

show abstract

“…Huang et al () suggested that the amount of NPs in endocytosis might be a key factor in the autophagic effect. Earlier studies have shown that various NPs induce autophagy in different cells by using TEM (Hussain et al, ; Sun et al, ; Laha et al, ; Huang et al, ; Lou et al, ). The ICP‐AES results showed increased concentrations of IONPs in the cells ( P < 0.05).…”

Section: Discussionmentioning

confidence: 99%

Iron oxide nanoparticles induced cytotoxicity, oxidative stress and DNA damage in lymphocytes

2017

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Over the past few decades nanotechnology and material science has progressed extremely rapidly. Iron oxide nanoparticles (IONPs) owing to their unique magnetic properties have a great potential for their biomedical and bioengineering applications. However, there is an inevitable need to address the issue of safety and health effects of these nanoparticles. Hence, the present study was aimed to assess the cytotoxic effects of IONPs on rats' lymphocytes. Using different assays, we studied diverse parameters including mitochondrial membrane potential, intracellular accumulation of reactive oxygen species (ROS), lactate dehydrogenase activity, antioxidant enzymes activity and DNA damage measurements. Intracellular metal uptake and ultrastructure analysis were also carried out through inductively coupled plasma atomic emission spectroscopy, transmission electron microscopy respectively. The results show that the IONP-induced oxidative stress was concentration-dependent in nature, with significant (P < 0.05) increase in ROS levels, lipid peroxidation level as well as depletion of antioxidant enzymes and glutathione. Moreover, we observed morphological changes in the cell after intracellular uptake and localization of nanoparticles in cells. From the findings of the study, it may be concluded that IONPs induce ROS-mediated cytotoxicity in lymphocytes. Copyright © 2017 John Wiley & Sons, Ltd.

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“…Another flavonoid, quercetin, is a potent antioxidant that is present in natural sources such as berries, onions, apples, and red wine [3, 55]. Quercetin’s anticancer efficacy in colon cancer and neurogliomas results from activating the novel cell death pathway, autophagy (type II programmed cell death), and mitogen-activated protein kinases (MAPK or extracellular signal-related kinase [ERK]) signaling pathways [56–58]. Accordingly, several studies on flavonoids support the potential role of flavonoids in both cancer treatment and prevention [1].…”

Section: Flavonoids In Cancer Chemopreventionmentioning

confidence: 99%

Cancer chemoprevention through dietary flavonoids: what’s limiting?

2017

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Flavonoids are polyphenols that are found in numerous edible plant species. Data obtained from preclinical and clinical studies suggest that specific flavonoids are chemo-preventive and cytotoxic against various cancers via a multitude of mechanisms. However, the clinical use of flavonoids is limited due to challenges associated with their effective use, including (1) the isolation and purification of flavonoids from their natural resources; (2) demonstration of the effects of flavonoids in reducing the risk of certain cancer, in tandem with the cost and time needed for epidemiological studies, and (3) numerous pharmacokinetic challenges (e.g., bioavailability, drug–drug interactions, and metabolic instability). Currently, numerous approaches are being used to surmount some of these challenges, thereby increasing the likelihood of flavonoids being used as chemo-preventive drugs in the clinic. In this review, we summarize the most important challenges and efforts that are being made to surmount these challenges.

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Quercetin nanoparticles induced autophagy and apoptosis through AKT/ERK/Caspase-3 signaling pathway in human neuroglioma cells: In vitro and in vivo

Cited by 107 publications

References 41 publications

Quercetin nanoparticle complex attenuated diabetic nephropathy via regulating the expression level of ICAM-1 on endothelium

Quercetin nanoparticle complex attenuated diabetic nephropathy via regulating the expression level of ICAM-1 on endothelium

Iron oxide nanoparticles induced cytotoxicity, oxidative stress and DNA damage in lymphocytes

Cancer chemoprevention through dietary flavonoids: what’s limiting?

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