Quercetin-induced amelioration of deltamethrin stress in freshwater teleost, Channa punctata: Multiple biomarker analysis

Bhattacharjee, Parmita; Borah, Anupom; Das, Suchismita

doi:10.1016/j.cbpc.2019.108626

Cited by 14 publications

(10 citation statements)

References 60 publications

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“…This improvement effect of quercetin could be due to its antioxidant activities, which in turn could stimulate immune cells in the nervous systems and induce antioxidant and antiinflammatory effects to maintain the integrity of the nervous systems [ 101 ]. In accordance with the present study, Bhattacharjee, et al [ 102 ] reported that supplementation of freshwater teleost, Channa punctata, with quercetin ameliorated the AchE inhibitory effect induced by deltamethrin. Eventually, the current findings emphasized that quercetin had an antioxidant role in controlling blood performance, biochemical, hepato-renal, and antioxidant alterations induced by ABM exposure in Nile tilapia.…”

Section: Discussionsupporting

confidence: 92%

Ameliorative Effect of Quercetin against Abamectin-Induced Hemato-Biochemical Alterations and Hepatorenal Oxidative Damage in Nile Tilapia, Oreochromis niloticus

Mansour

Mahboub

Amen

et al. 2022

Animals

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Abamectin (ABM) is a common agricultural pesticide and veterinary anthelmintic drug. It can discharge from the sites of application to aquatic systems via surface run-off or spray drift, causing harmful effects to aquatic organisms. The present study investigated the protective effect of dietary quercetin supplementation on hemato-biochemical parameters and hepato-renal oxidative stress biomarkers in Nile tilapia (Oreochromis niloticus) exposed to a sublethal dose of ABM. Fish were allocated into six equal groups. The first group was kept as a control group. The second and third groups (Q400, and Q800) were fed diets supplemented with two quercetin levels (400 and 800 mg/kg diet), respectively. The fourth group (ABM) was intoxicated with 20.73 µg/L of ABM. The fifth and sixth groups (ABM + Q400, and ABM + Q800) were fed diet supplemented with two quercetin levels (400 and 800 mg/kg diet) and simultaneously intoxicated with ABM for 60 days. The results showed that ABM significantly decreased RBCs, hemoglobin content, hematocrit, total protein, albumin levels, and acetylcholinesterase activity activities compared to the control. Meanwhile, ABM significantly increased white blood cells, glucose, total lipids, cholesterol, and alanine and aspartate aminotransferase activities. Liver and kidney levels of lipid peroxidation was significantly increased, while hepato-renal antioxidant biomarkers (reduced glutathione, super oxide dismutase, catalase, and total antioxidant capacity) were significantly decreased upon ABM exposure. On the other hand, quercetin dietary supplementation improved the hemato-biochemical alterations and alleviated oxidative stress induced by ABM exposure. Fish supplemented with quercetin at a level of 800 mg/kg diet showed better alleviating effects against ABM compared to 400 mg/kg diet. Based on these study findings, we suggest that quercetin dietary supplementation (800 mg/kg) offered direct protection against ABM-induced physiological disturbance and oxidative stress in Nile tilapia.

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Section: Discussionsupporting

confidence: 92%

Ameliorative Effect of Quercetin against Abamectin-Induced Hemato-Biochemical Alterations and Hepatorenal Oxidative Damage in Nile Tilapia, Oreochromis niloticus

Mansour

Mahboub

Amen

et al. 2022

Animals

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“…The increased concentration of WBC in response to QUR may indicate the immunogenic effects of QUR. Our results were in agreement with other studies on fish (Bhattacharjee et al, 2020; Ibrahim et al, 2021; Pês et al, 2016) and other vertebrates (Alam et al, 2017; Badr et al, 2019; Donmez et al, 2019; Patel et al, 2020; Selvakumar et al, 2013). Treatment of Channa punctata with QUR for 21 days recovered the deltamethrin‐induced decreases in RBC, WBC, Hb and Hct (Bhattacharjee et al, 2020).…”

Section: Discussionsupporting

confidence: 93%

“…Our results were in agreement with other studies on fish (Bhattacharjee et al, 2020; Ibrahim et al, 2021; Pês et al, 2016) and other vertebrates (Alam et al, 2017; Badr et al, 2019; Donmez et al, 2019; Patel et al, 2020; Selvakumar et al, 2013). Treatment of Channa punctata with QUR for 21 days recovered the deltamethrin‐induced decreases in RBC, WBC, Hb and Hct (Bhattacharjee et al, 2020). Ibrahim et al (2021) observed significant elevations in RBC, WBC, Hb and Hct, following supplementation of Nile tilapia with QUR nanoparticles.…”

Section: Discussionsupporting

confidence: 93%

Dietary quercetin improved growth, body composition, haematology, immunity and resistance to Aeromonas hydrophila infection in common carp ( Cyprinus carpio )

Jasim

Al‐Mosawi

Khalikov

et al. 2022

Aquaculture Research

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The present study was conducted to evaluate the growth, immunity, haematology, antioxidant components and resistances to Aeromonas hydrophila infection in the common carp, Cyprinus carpio fed quercetin (QUR) enriched diet. A number of 360 fish (30.5 ± 1.5 g) were distributed into 12 tanks (30 fish/tank) in three replicates and fed experimental diets containing 0% (control), 0.1% (1 g/kg diet), 0.5% (5 g/kg diet) and 1% (10 g/kg diet) QUR for 60 days. Based on the results, the survival and growth performance (weight gain [%], specific growth rate and feed conversion ratio) improved in response to dietary QUR (p < 0.01). The analysis of fish body composition indicated higher content of protein in 0.5% and 1% QUR-supplemented fish compared to others (p < 0.01). The plasma (complement activity, IgM content, lysozyme activity, bactericidal activity, total protein, total albumin) and mucus (IgM content, lysozyme activity) immune components significantly increased almost all in the supplemented fish compared to those in the control group; however, the highest values were observed in group of 1% QUR (p < 0.01). The mucosal protease and alkaline phosphatase increased only in fish fed 1% QUR (p < 0.01). The expression of the immune-related genes (C3, Lyz and IgM) significantly increased in response to 0.5 and 1% QUR compared to control (p < 0.01). The expression of the inflammatory genes, tumour necrosis factorα (TNFα) and interleukin-8 (IL-8) significantly declined in fish fed 1% QUR compared to supplemented fish. The activity of liver antioxidant enzymes [superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT)] was also increased by QUR supplementation. The highest liver antioxidant enzyme activity was found in group of 1% QUR (p < 0.01). The QUR supplementation also affected haematology of the fish. In this regard, the values of RBC, Hct and WBC significantly elevated in response to dietary QUR (p < 0.01). The MCHC and MCH indices significantly increased in fish fed 0.5 and 1% QUR compared to other diets (p < 0.01). As an indicator of oxidative stress, the levels of malondialdehyde (MDA) showed no significant differences between the experimental groups (p > 0.01). The fish supplemented with 0.5 and 1% QUR significantly showed higher survival rate after challenge with A. hydrophila compared to other experimental groups (p < 0.01). In conclusion, QUR at optimal

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“…In addition to its anticancer, antiviral, antibacterial, and anti-inflammatory effects, quercetin also has good antioxidant activity and free radical scavenging effects [ 33 ]. Previous studies have shown that quercetin is closely related to immune responses and disease resistance in aquatic animals [ 20 , 21 , 22 ]. Therefore, in this study, the anti-infective effect of quercetin combined with florfenicol in VP AHPND -infected L. vannamei was evaluated, and the combined effect of the two drugs was compared with the effect of quercetin or florfenicol used alone.…”

Section: Discussionmentioning

confidence: 99%

“…Quercetin has many biological activities such as anti-inflammatory, antioxidant, anti-tumor, and immune activities [ 18 , 19 ]. Adding quercetin to the diets of aquaculture animals improved their immunity and antioxidant capacity [ 20 , 21 , 22 ]. Thus, aquaculture animals’ disease resistance could involve both florfenicol and quercetin.…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Combined Utilization of Quercetin and Florfenicol on Acute Hepatopancreatic Necrosis Syndrome Infected Litopenaeus vannamei

Zhai

Chang

et al. 2022

Antibiotics

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This study aimed to determine the immunity, survival rate, and disease resistance of Litopenaeus vannamei treated using quercetin and florfenicol alone or in combination, after infection with acute hepatopancreatic necrosis syndrome caused by Vibrio parahaemolyticus (VPAHPND). After infection with VPAHPND, different types of feed were given to the shrimp for 5 days, including a control diet (drug-free), florfenicol only diet (15 mg/kg), quercetin only diet (400 mg/kg), a low-dose florfenicol/quercetin combined diet (200 mg/kg quercetin + 7.0 mg/kg florfenicol), a moderate-dose florfenicol/quercetin combined diet (400 mg/kg quercetin + 15 mg/kg florfenicol), and a high-dose florfenicol/quercetin combined diet (800 mg/kg quercetin + 30 mg/kg florfenicol). The cumulative mortality of shrimp was significantly reduced in the drug combination groups compared with either drug used alone (p < 0.05). The density of Vibrio was significantly lower and the immune parameters were significantly increased in the drug combination groups compared with either drug used alone (p < 0.05). Moreover, in the drug combination groups, the hepatopancreas tubules showed better integrity and structure compared with those when either drug was used alone. Therefore, compared with single drug treatment, the florfenicol and quercetin combination enhanced disease resistance, survival, and immune activity of VPAHPND-infected shrimp. When the combination treatment is used, the dosage of florfenicol can be reduced and a better therapeutic effect is obtained.

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Quercetin-induced amelioration of deltamethrin stress in freshwater teleost, Channa punctata: Multiple biomarker analysis

Cited by 14 publications

References 60 publications

Ameliorative Effect of Quercetin against Abamectin-Induced Hemato-Biochemical Alterations and Hepatorenal Oxidative Damage in Nile Tilapia, Oreochromis niloticus

Ameliorative Effect of Quercetin against Abamectin-Induced Hemato-Biochemical Alterations and Hepatorenal Oxidative Damage in Nile Tilapia, Oreochromis niloticus

Dietary quercetin improved growth, body composition, haematology, immunity and resistance to Aeromonas hydrophila infection in common carp ( Cyprinus carpio )

Protective Effects of Combined Utilization of Quercetin and Florfenicol on Acute Hepatopancreatic Necrosis Syndrome Infected Litopenaeus vannamei

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