Quercetin Diminishes the Binding of Hemoglobin to the Red Blood Cell Membrane

Cesquini, Maristela; Tenor, A.C.; Torsoni, Márcio Alberto; Stoppa, Graziela R.; Pereira, Ariovaldo Lopes; Ogo, Satie Hatsushika

doi:10.1089/109454501750225695

Cited by 6 publications

(2 citation statements)

References 46 publications

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“…In agreement with previous reports (Trotta et al 1982;Rice-Evans et al 1985), the presence of t-BOOH leads to the formation of metHb and hemichrome in Hb solution. Exposure of intact RBC to t-BOOH also caused lipid peroxidation and the binding of Hb to membrane (Chiu et al 1996;Cesquini et al 2001).…”

Section: Discussionmentioning

confidence: 99%

The Beneficial Effect of Three Flavonols Against Oxidative Damage

Pereira

Cesquini

Tomizawa

et al. 2003

J Food Biochemistry

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The ability of three related naturally occurring flavonols in inhibiting Hb oxidation and lipid peroxidation of human erythrocyte membranes was evaluated. The flavonols tested exhibited the following order of potency to inhibit tert‐butyl hydroperoxide‐induced Hb oxidation: quercetin > rutin > morin. The Hb oxidation was estimated by the extent of metHb and hemichrome formation induced by tert‐butyl hydroperoxide. Quercetin or rutin (0.5 mM) increased oxyHb levels about 33% and 10%, respectively. Morin (0.5 mM) was pro‐oxidant, decreasing the oxyHb about 7%. Despite the pro‐oxidant action on Hb oxidation, morin offered greater protection against lipid peroxidation than rutin, preventing the formation of TBA reactive substances by 33.1%, at 0.2 mM. However, quercetin (0.2 mM) provided approximately 50% protection against TBARS formation. The results show that the flavonoids tested are protective for Hb oxidation and lipid peroxidation on erythrocyte membrane subjected to oxidative stress. Quercetin in particular, may be useful in diminishing oxidative damage to red blood cells

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Section: Discussionmentioning

confidence: 99%

The Beneficial Effect of Three Flavonols Against Oxidative Damage

Pereira

Cesquini

Tomizawa

et al. 2003

J Food Biochemistry

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“…Hb oxidation leads to the formation of hemichrome, which binds to the membrane and causes RBC removal by the reticuloendothelial system. Quercetin has previously been shown to reduce the levels of the membrane-bound hemichrome and to suppress lipid peroxidation (12).…”

Section: Ameliorative Potentials Of Quercetin Against Lead-induced Hementioning

confidence: 99%

Ameliorative Potentials of Quercetin against Lead-Induced Hematological and Testicular Alterations in Albino Rats

2017

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Lead is one of the oldest environmental and occupational toxins. Health hazards from increased lead exposure as a result of industrial and environmental pollution are recognized. The aim of the present study was to investigate the protective effects of quercetin as a model of an antioxidant drug against the toxic effects of lead acetate on the blood and the testis of rats. The lead concentrations were determined in blood and the testis. Testosterone (T), luteinizing hormone (LH) and follicle stimulating hormone (FSH) were assessed in serum. Hemoglobin (Hb) content, packed cell volume (PCV), white blood cell (WBC) and red blood cell (RBC) counts were evaluated in the whole blood. Our results showed that administration of lead acetate was associated with an increased lead levels in blood as well as in the testis. Lead acetate administration also caused a decrease in testicular function, Hb content, PCV and RBC count in comparison to the respective mean values of the control. In addition, lead acetate increased WBC count and induced alterations in sperm count, sperm motility and sperm abnormality and histopathology. In the contrary, administration of lead acetate along with quercetin partially restored the studied parameters to normal values. In conclusion, the treatment with quercetin may provide a partial protection against the toxic effects induced by lead acetate in blood and the testis of rats.

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