Ameliorative Potentials of Quercetin against Lead-Induced Hematological and Testicular Alterations in Albino Rats

Al‐Omair, Mohammed A.; Sedky, A.; Ali, Alaa E.

doi:10.4077/cjp.2017.baf440

Cited by 17 publications

(6 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Strategies to minimise oxidative stress using quercetin have been tested and reported in both in vitro and in vivo experiments, with diverse findings. Some reports indicated an improvement in semen quality (Aldemir et al, 2014;Al-Omair et al, 2017) and testicular histograms (Bharti et al, 2016;Abd-Ellah et al, 2016); in contrast, others have found either no improvement on the variables cited above or a damaging effect of quercetin supplementation, such as increased rates of sperm morphology and reduced motility (Liang et al, 2016;Filho et al, 2017). Generally, the recommendation of oral antioxidants during infertility cases is a routine practice amongst human and veterinarian clinicians and this practice is based on the premise that increased seminal oxidative stress could be linked to the deficiency in seminal antioxidants (Fanaei et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Impact of quercetin supplementation on testicular functions in summer heat-stressed rabbits

et al. 2020

View full text Add to dashboard Cite

<p>The current study was designed to determine the effects of dietary quercetin on epididymal sperm and testicular changes in male rabbits during summer heat stress (HS). Twelve adult male New Zealand white rabbits were submitted to summer heat conditions (temperature-humidity index 29.9±1.2). One group was fed a basal ration (BR; n = 6), whereas the other group was fed the same basal diet supplemented with quercetin (30 mg/kg d; Que-BR; n = 6) for 60 d, and both groups were sacrificed at the end of the experiment. Epididymis and testicles isolation was done for sperm, histopathology and apoptosis assessments. The results showed that quercetin improved epididymis weight, but did not affect other testicular dimensions except testicular length. A significant improvement was observed in epididymal sperm motility, concentration, kinematic parameters, viability, mitochondrial potential and acrosome integrity in Que-BR compared to the BR group. Lowered serum malondialdehyde level was observed in quercetin supplemented rabbits. Moreover, the quercetin supplementation maintained the interstitial stroma, seminiferous tubules architecture, germinal and Sertoli cells under HS, decreasing the apoptotic germ cell rate in seminiferous tubules. In conclusion, HS condition affects the sperm and testes configurations in rabbits and dietary quercetin minimises oxidative stress, which in turn protects the testes and sperm against HS induced damage.</p>

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of quercetin supplementation on testicular functions in summer heat-stressed rabbits

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Quercetin (QCN) co-administration ameliorated Pb-adversely toxic alterations that impacted the cellular organization and activation of the apoptotic pathways in the testis (Al-Omair et al 2017 ; Khodabandeh et al 2021 ). Moreover, the oxidative injury was significantly recovered, and the antioxidant biomarkers such as GSH levels, SOD, and CAT activities were close to normal with co-administration of QCN, and the toxic symptoms following exposure to Al 2 O 3 NPs in mice were avoided (Shrivastava et al 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Ameliorative effects of quercetin against hepatic toxicity of oral sub-chronic co-exposure to aluminum oxide nanoparticles and lead-acetate in male rats

Abo‐EL‐Sooud

Abd‐Elhakim

Hashem

et al. 2022

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

The present study was designed to evaluate the probable ameliorative role of quercetin (QCN) against oxidative hepatotoxicity induced by aluminum oxide nanoparticles (Al2O3NPs) with a diameter < 30 nm and lead acetate (Pb) co-exposure in adult male Sprague–Dawley rats. Rats were weighed and allocated to seven groups (n = 10 each) and were treated orally via orogastric gavage for 60 successive days: rats of the 1st group were kept as control given distilled water (1 ml/kg), rats of the 2nd group received 2 ml/kg BW/day corn oil; rats of the 3rd group were administered 20 mg/kg BW QCN/day; rats of the 4th group received 100 mg/kg BW Al2O3NPs; rats of the 5th group received 50 mg/kg BW Pb; rats of the 6th group co-received Al2O3NPs and Pb at the same previous doses; and rats of the 7th group were co-administered Al2O3NPs, Pb, and QCN at the same previous doses. At the end of the experiment, serum levels of alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total, direct, indirect bilirubin, triglycerides, total cholesterol, HDL, VLDL, and LDL were estimated. The hepatic oxidative stress biomarkers as superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione peroxidase (GPx), were also evaluated. Finally, the histopathological and histomorphometric evaluations and the residues of Al and Pb in hepatic tissues were assessed. Al2O3NPs and/or Pb exposure significantly elevated lipid peroxidation levels and considerably altered the hepatic biochemical parameters; nevertheless, QCN significantly reduced hepatic enzymes compared to toxicant exposed groups. Additionally, QCN significantly improved Al2O3NPs-afforded liver tissue damage, as established in microscopic findings on the liver in the group treated with Al2O3NPs + Pb. Conclusively, QCN could be a candidate natural agent to safeguard the liver versus the co-harmful impacts of Al2O3NPs and Pb toxicity.

show abstract

“…The damaged testis tissue in LA group is supported by (Al-Omair et al, 2017) who showed degenerations, and deformities in the testis architecture. Also, testis damage by LA was confirmed in the rat by (Mabrouk, 2018;Ali and Al-Derawi, 2018).…”

Section: Discussionmentioning

confidence: 78%

Effect of Vitamin C Against Lead Acetate Toxicity on Sperm Count, Sperm Morphology and Testis Tissue in the Rat Before and in Recovery Period

2020

ZJPAS

View full text Add to dashboard Cite

The present study was conducted to investigate the effect of lead acetate (LA) (30 mg/Kg B.wt/day), and vitamin C (Vit.C) (100 mg/Kg B.wt/day) against LA toxicity in adult male rats. The design of study included two experiments (exp.). In exp-I rats were divided into 3 groups. Group I: control, group II: received LA, and group III: received LA coadministrated with Vit.C, for 6 weeks. In exp-II rats were divided into 4 groups. Group I: control, group II: received LA, group III: received LA coadministrated with Vit.C, and group IV: received LA. The groups were treated for 6 weeks, then groups II, &III in order to be recover were left without treatment (as control) for additional 6 weeks. While group IV after cessation of LA received Vit.C within recovery period (for 6 weeks). At the end of each experiment rats were sacrificed. Blood samples were collected and used for determination of serum MDA. Histological sections were made from testis. Sperm characteristics included sperm count was determined from caudal epididymis and sperm abnormalities from left vas deferens. In exp-I, LA group showed significantly decreased sperm count, significant increase in sperm abnormalities and MDA, and testicular tissue damage. While in group III Vit.C against LA significantly improved sperm characteristics and testicular tissue as well. In exp-II, Group II showed almost no improvement in sperm characteristics and testicular tissue, whereas MDA was increased non-significantly from control. In group III the coadministrated Vit.C with LA, markedly improved sperm characteristics, and testicular tissue similar to Vit.C against LA in exp-I. Meanwhile, the improvement by Vit.C in group IV was occurred in lesser extent. In conclusions, Vit.C had a protective effect against LA toxicity, and it was markedly more effective when coadministrated along with LA rather than its administration after cessation of LA.

show abstract

Ameliorative Potentials of Quercetin against Lead-Induced Hematological and Testicular Alterations in Albino Rats

Cited by 17 publications

References 35 publications

Impact of quercetin supplementation on testicular functions in summer heat-stressed rabbits

Impact of quercetin supplementation on testicular functions in summer heat-stressed rabbits

Ameliorative effects of quercetin against hepatic toxicity of oral sub-chronic co-exposure to aluminum oxide nanoparticles and lead-acetate in male rats

Effect of Vitamin C Against Lead Acetate Toxicity on Sperm Count, Sperm Morphology and Testis Tissue in the Rat Before and in Recovery Period

Contact Info

Product

Resources

About