Quercetin and rutin prevent scopolamine-induced memory impairment in zebrafish

Behavioral screening for neuroactive drugs in zebrafish

“…Anxiolytics, including nicotine (Levin et al, 2007;Bencan and Levin, 2008), buspirone, diazepam, and fluoxetine (Bencan et al, 2009;Maximino et al, 2011), and anxiogenics such as caffeine (Egan et al, 2009) alter adult zebrafish anxiety-related behavioral responses as assessed by either a novel tank or light/dark preference paradigms. Drugs that affect adult zebrafish learning and memory tests include nicotine (Levin and Chen, 2004;Levin et al, 2006), the anti-cholinergic scopolamine (Kim et al, 2010;Richetti et al, 2011), the antihistaminerigc a-fluoromethylhistidine (Peitsaro et al, 2003), the NMDA receptor antagonist MK-801 (Swain et al, 2004;Blank et al, 2009), environmental neurotoxins , and melatonin (Rawashdeh et al, 2007). Some work has also been done on the effects of neuroactive drugs on larval zebrafish locomotor behavior.…”

Combretum mucronatumandCapparis thonningiiprevent scopolamine-induced memory deficit in mice

“…The ability of methanol root extract of C. mucronatum and C. thonningii to reverse scopolamine-induced memory deficit could probably result from the activities of their polyphenolics constituents (Richetti et al, 2011). The effects of a flavonoid-rich diet on cognitive function have been linked to the ability of flavonoids to interact with the cellular and molecular framework involved in learning and memory, including synaptic potentiation and plasticity (Harvsteen, 2002).…”

“…Preliminary study in our laboratory has shown that C. mucronatum and C. thonningii are rich in polyphenol (using quercetin as standard). Quercetin and rutin are natural compounds widely found in the diet, have been studied for a long time and shown to have wide physiological effects (Singh et al, 2008), including antidementic effects in zebrafish (Richetti et al, 2011). The effects of a flavonoid-rich diet on cognitive function have been linked to the ability of flavonoids to interact with the cellular and molecular framework involved in learning and memory, including synaptic potentiation and plasticity (Harvsteen, 2002).…”

Neurocognitive Improvement Through Plant Food Bioactives: A Particular Approach to Alzheimer’s Disease

“…Among the tested commercial flavones, luteolin showed a dose-dependent effect, mainly acting as downregulator of NF-Kb and BACE-1, and decreased Ab deposition (Fu et al 2014). On the other hand, by using a standard concentration of 50 mg/kg b.w., Richetti et al (2011) observed that both flavonols, quercetin and rutin, were able to prevent memory and cognitive impairments. Similarly, Mori et al (2013) observed that ferulic acid (30 mg/kg b.w.)…”