Combretum mucronatumandCapparis thonningiiprevent scopolamine-induced memory deficit in mice

Novel potential of metformin on valproic acid‐induced autism spectrum disorder in rats: involvement of antioxidant defence system

“…Findings from this study showed that in utero VPA exposure resulted in poor spatial learning ability evidenced in the prolongation of escape latency in MWM task. More so, we have earlier reported strong correlation between escape latency and path length in MWM task [48]. Moreover, in the probe trial, VPA significantly reduced time spent at platform location indicative of reference memory deficit.…”

Antidepressant and Anxiolytic Effects of the Methanol Root Extract of Capparis thonningii: Involvement of Monoaminergic, Cholinergic and GABAergic Systems

“…The antidepressant-like action of the extract was confi rmed in the TST. In addition, the antidepressant-like eff ect of extract cannot be attributed to psychostimulant eff ect as shown in the open fi eld test, it did not aff ect signifi cantly the ambulatory or rearing behaviour in the digiscan activity meter [ 4 ] . This indicates that increased motor activity were not involved in the action seen in both FST and TST, and confi rms the assumption that the antidepressant-like eff ect of the extract is specifi c. It has been demonstrated that swimming is sensitive to serotoninergic compounds, such as the selective serotonin reuptake inhibitor fl uoxetine, and that climbing is sensitive to tricyclic antidepressants and drugs with selective eff ects on noradrenergic transmission [ 26 -28 ] .…”

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“…as a means of enhancing wound healing 6 . The methanol root extracts of C. mucronatum has also been shown to have anti-inflammatory effects invivo by interaction with the opioid pathway 2 .…”

“…The methanol extract has also been shown to have activity against some pathogenic bacteria, namely: Streptococcus pyogenes, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus cereus, and Bacillus subtilis 3 . Recent investigations have also shown that C. mucronatum prevents scopolamineinduced memory deficit in mice due to its significant anti-cholinesterase, antioxidant and antidementic properties, and may be useful in the management of Alzheimer's disease 2 .…”