Neurocognitive Improvement Through Plant Food Bioactives: A Particular Approach to Alzheimer’s Disease

Martins, Natália; Ferreira, Isabel C.F.R.

doi:10.1007/978-3-319-51639-4_11

Cited by 7 publications

(6 citation statements)

References 92 publications

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“…Various cholinesterase inhibitors such as galantamine, tacrine, and rivastigmine are produced synthetically. However, these drugs have side effects such as nausea, diarrhea, dizziness, and vomiting [14]. For these reasons, the discovery of natural and safe enzyme inhibitors has become inevitable.…”

Section: Anticholinergic Activitymentioning

confidence: 99%

Investigation of Anticholinesterase and Anticancer Effects of Verbascum insulare Boiss. Et Heldr. Extracts Growing in Mus Region

Alan

Almaz

2022

Bitlis Eren Üniversitesi Fen Bilimleri Dergisi

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Since the existence of humanity, plants have been used in many treatment methods. Members of the genus Verbascum, also known as mullein, a member of the Scrophulariaceae family, have been evaluated for their traditional use against various ailments. In this study, the anticholinesterase and anticancer activities of Verbascum member Verbascum insulare Boiss. Et Heldr. collected from Muş region were investigated. V. insulare leaf ethanol (L-EtOH), leaf purified water (L-PW), root ethanol (R-EtOH), and root purified water (R-PW) extracts were obtained. The anticancer activity of the extracts against HT-29, MCF-7, and L-929 cell lines was examined using the 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test and the anticholinesterase activity was determined. It was found that the ethanol extract showed higher anticancer activity against cancer cell lines than the pure water extract and had more effective anticholinergic influences. No study has been found in the literature on the anticancer and anticholinesterase activity of this plant. Therefore, the results obtained from this study will contribute significantly to the development of herbal medicine in the future.

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Section: Anticholinergic Activitymentioning

confidence: 99%

Investigation of Anticholinesterase and Anticancer Effects of Verbascum insulare Boiss. Et Heldr. Extracts Growing in Mus Region

Alan

Almaz

2022

Bitlis Eren Üniversitesi Fen Bilimleri Dergisi

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“…Various cholinesterase inhibitors such as galantamine, tacrine, and rivastigmine are produced synthetically (Gülçin et al, 2016;Taslimi et al, 2017;Biçer et al, 2019). However, these drugs have side effects such as nausea, diarrhoea, dizziness, and vomiting (Martins and Ferreira, 2017). For these reasons, the discovery of natural and safe enzyme inhibitors has become inevitable.…”

Section: Anticholinergics Activitymentioning

confidence: 99%

Biological active compounds and biological activities of the foam used in the traditional kerebiç dessert

Savcı¹

2022

IFRJ

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In the present work, foam and water extracts were obtained from Gypsophila root, which forms the foam part of the dessert known as kerebiç. The bioactive compounds of samples were analysed with Fourier transform infrared (FT-IR) and high-performance liquid chromatography (HPLC). To determine their antioxidant properties, ferric-reducing antioxidant power (FRAP) method, cupric-reducing antioxidant capacity (CUPRAC) method, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonate (ABTS) method, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging method, and total antioxidant activity method were performed. The pUC18 plasmid DNA was used to investigate the effect of the samples on the deoxyribonucleic acid (DNA). In addition, the inhibitory properties of the samples against key enzymes (acetyl and butyryl-cholinesterases) involved in the pathogenesis of diseases were investigated. Based on the results of FT-IR analysis, terpenes and sugars were detected in the extracts. Based on the HPLC results, glucose, fructose, maleic acid, acetic acid, acetoin, and 2,3 butanediol were detected in the extracts. Antioxidant results showed that extracts had similar and moderate activities as compared to the standard antioxidants. It was observed that the extracts preserved the stable structure of pUC18 plasmid DNA, but could not remove the scavenging effect of peroxide. In addition, it was determined that the extracts showed a stronger inhibitory effect on acetylcholinesterase (AChE) and butyryl-cholinesterases (BChE) than galantamine, which was used as the control.

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“…It also inhibits 12/15-lipoxygenases and GSK3 β activity, reduces BACE1 and A β production, prevents tau phosphorylation, and restores spine density and LTP in AD model [ 165 , 166 ]. In addition to inhibiting A β -induced depolarization, 19 also functions as an antagonist of AMPA ( α -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) and NMDA receptors and improves neurocognition [ 167 , 168 ]. It also attenuates neurological deficits and preserves blood-brain barrier integrity in a rat model of intracerebral hemorrhage and inhibits AChE [ 169 – 172 ].…”

Section: Classical Examples Of Neuroprotective Drugs Of Plant-origmentioning

confidence: 99%

Plants-Derived Neuroprotective Agents: Cutting the Cycle of Cell Death through Multiple Mechanisms

Elufioye

Berida

Habtemariam

2017

Evidence-Based Complementary and Alternative Medicine

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Neuroprotection is the preservation of the structure and function of neurons from insults arising from cellular injuries induced by a variety of agents or neurodegenerative diseases (NDs). The various NDs including Alzheimer's, Parkinson's, and Huntington's diseases as well as amyotropic lateral sclerosis affect millions of people around the world with the main risk factor being advancing age. Each of these diseases affects specific neurons and/or regions in the brain and involves characteristic pathological and molecular features. Hence, several in vitro and in vivo study models specific to each disease have been employed to study NDs with the aim of understanding their underlying mechanisms and identifying new therapeutic strategies. Of the most prevalent drug development efforts employed in the past few decades, mechanisms implicated in the accumulation of protein-based deposits, oxidative stress, neuroinflammation, and certain neurotransmitter deficits such as acetylcholine and dopamine have been scrutinized in great detail. In this review, we presented classical examples of plant-derived neuroprotective agents by highlighting their structural class and specific mechanisms of action. Many of these natural products that have shown therapeutic efficacies appear to be working through the above-mentioned key multiple mechanisms of action.

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Neurocognitive Improvement Through Plant Food Bioactives: A Particular Approach to Alzheimer’s Disease

Cited by 7 publications

References 92 publications

Investigation of Anticholinesterase and Anticancer Effects of Verbascum insulare Boiss. Et Heldr. Extracts Growing in Mus Region

Investigation of Anticholinesterase and Anticancer Effects of Verbascum insulare Boiss. Et Heldr. Extracts Growing in Mus Region

Biological active compounds and biological activities of the foam used in the traditional kerebiç dessert

Plants-Derived Neuroprotective Agents: Cutting the Cycle of Cell Death through Multiple Mechanisms

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