Quercetin alleviates thermal and cold hyperalgesia in a rat neuropathic pain model by inhibiting Toll-like receptor signaling

Ji, Chunmei; Xu, Yongsheng; Fang, Haisheng; Sun, Dehai; Zhang, Hanli; Li, Xiumei; Yao, Xiaoyin; Wang, Hong

doi:10.1016/j.biopha.2017.07.145

Cited by 42 publications

(29 citation statements)

References 28 publications

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“…SNL-induced mechanical allodynia has been reduced by baicalein [166], EGCG [167], and myricetin [168]. Baicalein [166] and myricetin [168] attenuated SNL-induced thermal hyperalgesia, whereas quercetin attenuated both thermal and cold hyperalgesia in SNL rats [169]. Moreover, pre-administration of quercetin attenuated neuropathic symptoms [169].…”

Section: Spinal Nerve Ligation (Snl)mentioning

confidence: 98%

“…Baicalein [166] and myricetin [168] attenuated SNL-induced thermal hyperalgesia, whereas quercetin attenuated both thermal and cold hyperalgesia in SNL rats [169]. Moreover, pre-administration of quercetin attenuated neuropathic symptoms [169]. In addition to inhibiting neuropathic pain behavior in SNL rats, quercetin inhibited inflammatory response by inhibiting pro-inflammatory cytokines TNF-α and IL-1β and reduced CCL-2 and MMPs [169], which play important roles in the pathogenesis of neuropathic pain [105,170].…”

Section: Spinal Nerve Ligation (Snl)mentioning

confidence: 99%

“…In addition to inhibiting neuropathic pain behavior in SNL rats, quercetin inhibited inflammatory response by inhibiting pro-inflammatory cytokines TNF-α and IL-1β and reduced CCL-2 and MMPs [169], which play important roles in the pathogenesis of neuropathic pain [105,170]. The study further confirmed that quercetin inhibited TLR signaling pathway and NF-κB through activating transforming growth factor-β-activated kinase (TAK-1) [169]. Baicalein has been reported to reverse global histone-H3 acetylation and suppress HDAC1 expression [166].…”

Section: Spinal Nerve Ligation (Snl)mentioning

confidence: 99%

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In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain

Basu

2020

Molecules

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Neuropathic pain is a common symptom and is associated with an impaired quality of life. It is caused by the lesion or disease of the somatosensory system. Neuropathic pain syndromes can be subdivided into two categories: central and peripheral neuropathic pain. The present review highlights the peripheral neuropathic models, including spared nerve injury, spinal nerve ligation, partial sciatic nerve injury, diabetes-induced neuropathy, chemotherapy-induced neuropathy, chronic constriction injury, and related conditions. The drugs which are currently used to attenuate peripheral neuropathy, such as antidepressants, anticonvulsants, baclofen, and clonidine, are associated with adverse side effects. These negative side effects necessitate the investigation of alternative therapeutics for treating neuropathic pain conditions. Flavonoids have been reported to alleviate neuropathic pain in murine models. The present review elucidates that several flavonoids attenuate different peripheral neuropathic pain conditions at behavioral, electrophysiological, biochemical and molecular biological levels in different murine models. Therefore, the flavonoids hold future promise and can be effectively used in treating or mitigating peripheral neuropathic conditions. Thus, future studies should focus on the structure-activity relationships among different categories of flavonoids and develop therapeutic products that enhance their antineuropathic effects.

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Section: Spinal Nerve Ligation (Snl)mentioning

confidence: 98%

Section: Spinal Nerve Ligation (Snl)mentioning

confidence: 99%

Section: Spinal Nerve Ligation (Snl)mentioning

confidence: 99%

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In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain

Basu

2020

Molecules

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“…It is widely distributed in vegetables and herbal preparations and found in high concentrations in broccoli and capers. It is also found in high concentrations (with kaempferol) in raspberry leaf herbal extract and recently has shown safety and efficacy to treat oral lichen planus and an animal model of neuropathic pain .…”

Section: Natural Compoundsmentioning

confidence: 99%

Cell‐based therapies and natural compounds for pain

Shparberg

Vickers

2018

Aust Endodontic J

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Cell-based therapies and natural compounds are increasingly being acknowledged for their potential roles in managing a variety of conditions, including pain. Stem cells have gained attention over the years for their contribution to our understanding of normal and abnormal physiology, their capacity to assist in efficient drug design and screening and their role in regenerative medicine. This chapter will review our current understanding of the complex pathophysiology of pain using adult, embryonic and induced pluripotent stem cells as models. In addition, this chapter outlines several natural compounds that are used in the treatment of neuropathic pain, with a focus on evidence-based information of the polyphenols, polyamines and endocannabinoids derived from plants and food sources. Advantages of these compounds are the higher margins of safety, low incidence of side effects. Recent evidence shows several polyphenols can induce differentiation of healthy stem cells yet inhibit cancer stem cells.

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“…Here, we summarize the recent studies that have evaluated the biological and pharmacological activities of quercetin (Table 1 (Tab. 1) ; References in Table 1: Abdelhalim et al, 2018[ 1 ]; Afifi et al, 2018[ 2 ]; Aghapour et al, 2018[ 3 ]; Ahmed et al, 2018[ 4 ]; Al-Asmari et al, 2018[ 5 ]; Ansar et al, 2016[ 7 ]; Atef et al, 2017[ 8 ]; Beghoul et al, 2017[ 9 ]; Calgarotto et al, 2018[ 11 ]; Chan et al, 2018[ 12 ]; Chang et al, 2017[ 13 ]; Chen et al, 2017[ 14 ]; Damiano et al, 2018[ 16 ]; Dong et al, 2017[ 17 ]; Duranti et al, 2018[ 18 ]; Esrefoglu et al, 2017[ 20 ]; Funakoshi et al, 2017[ 22 ]; Guo et al, 2017[ 23 ]; He et al, 2016[ 24 ]; Huang et al, 2017[ 25 ]; Jeon et al, 2017[ 26 ]; Ji et al, 2017[ 27 ]; Ju et al, 2018[ 28 ]; Kee et al, 2016[ 29 ]; Lan et al, 2017[ 30 ]; Lazo-Gomez and Tapia, 2017[ 31 ]; Li et al, 2018[ 32 ]; Liu and Zhou, 2017[ 34 ]; Liu et al, 2017[ 35 ]; Lu et al, 2018[ 36 ]; Maciel et al, 2016[ 37 ]; Maksymchuk et al, 2017[ 38 ]; Mitani et al, 2017[ 40 ]; Mkhize et al, 2017[ 41 ]; Naseer et al, 2017[ 42 ]; Pandya et al, 2017[ 45 ]; Patrizio et al, 2018[ 46 ]; Qin et al, 2017[ 47 ]; Ren et al, 2018[ 48 ]; Sameni et al, 2018[ 49 ]; Singh et al, 2018[ 51 ]; Sohn et al, 2018[ 52 ]; Tinay et al, 2017[ 53 ]; Veith et al, 2017[ 54 ]; Wu et al, 2018[ 55 ]; Xingyu et al, 2016[ 56 ]; Yang et al, 2017[ 57 ]; Yang et al, 2018[ 58 ]; Yarahmadi et al, 2017[ 60 ]; Yarahmadi et al, 2018[ 59 ]; Yazıcı et al, 2018[ 61 ]; Yuan et al, 2016[ 63 ]; Yuan et al, 2018[ 62 ]; Zhang et...…”

mentioning

confidence: 99%