Quercetin and its role in biological functions: an updated review

Kim, Jae Kwang; Park, Sang Un

doi:10.17179/excli2018-1538

Cited by 35 publications

(21 citation statements)

References 66 publications

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“…Quercetin, yet another important and well-investigated compound from propolis, similar to caffeic acid, CAPE, and other propolis-related molecules, displays proapoptotic, anti-invasive, and antiangiogenic properties [ 367 , 368 , 369 , 370 , 371 , 372 , 373 , 374 , 375 ]. Epidemiological studies have indicated that supplementation with quercetin may be associated with the prevention of lung, breast, colon, ovarian, and prostate cancer [ 367 , 368 , 369 , 370 , 371 , 374 , 375 ]. Quercetin decreased the invasion of the highly metastatic B16-BL6 melanoma cells in vitro [ 376 ].…”

Section: Antitumor Activity Of Propolis and Its Polyphenolic/flavonoi...mentioning

confidence: 99%

Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer

Oršolić

Jembrek

2022

IJMS

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In recent years, interest in natural products such as alternative sources of pharmaceuticals for numerous chronic diseases, including tumors, has been renewed. Propolis, a natural product collected by honeybees, and polyphenolic/flavonoid propolis-related components modulate all steps of the cancer progression process. Anticancer activity of propolis and its compounds relies on various mechanisms: cell-cycle arrest and attenuation of cancer cells proliferation, reduction in the number of cancer stem cells, induction of apoptosis, modulation of oncogene signaling pathways, inhibition of matrix metalloproteinases, prevention of metastasis, anti-angiogenesis, anti-inflammatory effects accompanied by the modulation of the tumor microenvironment (by modifying macrophage activation and polarization), epigenetic regulation, antiviral and bactericidal activities, modulation of gut microbiota, and attenuation of chemotherapy-induced deleterious side effects. Ingredients from propolis also ”sensitize“ cancer cells to chemotherapeutic agents, likely by blocking the activation of the transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). In this review, we summarize the current knowledge related to the the effects of flavonoids and other polyphenolic compounds from propolis on tumor growth and metastasizing ability, and discuss possible molecular and cellular mechanisms involved in the modulation of inflammatory pathways and cellular processes that affect survival, proliferation, invasion, angiogenesis, and metastasis of the tumor.

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Section: Antitumor Activity Of Propolis and Its Polyphenolic/flavonoi...mentioning

confidence: 99%

Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer

Oršolić

Jembrek

2022

IJMS

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“…For example, catechins appear to be absorbed in amount smaller than intake due to their rapid metabolization [ 214 ]. Therefore, an increase in the bioavailablity of flavonoids envisaged by current research [ 215 ]. To this end, complexity and chronicity as basic characteristcs of plenty of human diseases as well as sex, age, comorbidities, genetic similarity, and environmental factors should be carefully considered and appropriately modeled in research and individualised application of flavonoids [ 216 ].…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Flavonoids against non-physiologic inflammation attributed to cancer initiation, development, and progression—3PM pathways

et al. 2021

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Inflammation is an essential pillar of the immune defense. On the other hand, chronic inflammation is considered a hallmark of cancer initiation and progression. Chronic inflammation demonstrates a potential to induce complex changes at molecular, cellular, and organ levels including but not restricted to the stagnation and impairment of healing processes, uncontrolled production of aggressive ROS/RNS, triggered DNA mutations and damage, compromised efficacy of the DNA repair machinery, significantly upregulated cytokine/chemokine release and associated patho-physiologic protein synthesis, activated signaling pathways involved in carcinogenesis and tumor progression, abnormal tissue remodeling, and created pre-metastatic niches, among others. The anti-inflammatory activities of flavonoids demonstrate clinically relevant potential as preventive and therapeutic agents to improve individual outcomes in diseases linked to the low-grade systemic and chronic inflammation, including cancers. To this end, flavonoids are potent modulators of pro-inflammatory gene expression being, therefore, of great interest as agents selectively suppressing molecular targets within pro-inflammatory pathways. This paper provides in-depth analysis of anti-inflammatory properties of flavonoids, highlights corresponding mechanisms and targeted molecular pathways, and proposes potential treatment models for multi-level cancer prevention in the framework of predictive, preventive, and personalized medicine (PPPM / 3PM). To this end, individualized profiling and patient stratification are essential for implementing targeted anti-inflammatory approaches. Most prominent examples are presented for the proposed application of flavonoid-conducted anti-inflammatory treatments in overall cancer management.

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“…Quercetin is a unique bioflavonoid ubiquitously found in onion, broccoli, apples, berries, tea, and red wines. Quercetin has been reported with a wide range of therapeutic activities, such as antioxidant, anti-inflammatory, anti-amyloidogenic, and neuroprotective activities [ 14 , 15 , 16 , 17 ]. The ability of quercetin to inhibit xanthine oxidase and lipid peroxidation or its oxygen-scavenging activity exerts its neuroprotective activity [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effect of Quercetin and Memantine against AlCl3-Induced Neurotoxicity in Albino Wistar Rats

Jadhav

Kulkarni

2023

Molecules

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Recent evidences indicate that there is a substantial increase in worldwide cases of dementia. Alzheimer's disease is the leading cause of dementia and may contribute to 60–70% of cases. Quercetin is a unique bioflavonoid that has numerous therapeutic benefits such as anti-allergy, anti-ulcer, anti-inflammatory, anti-hypertensive, anti-cancer, immuno-modulatory, anti-infective, antioxidant, acetylcholinesterase inhibitory activity, neuroprotective effects, etc. In the present study, we evaluated the neuroprotective effect of orally administered quercetin with memantine in albino Wistar rats after inducing neurotoxicity through AlCl3 (100 mg/kg, p.o.). Chronic administration of AlCl3 resulted in poor retention of memory and significant oxidative damage. Various behavioral parameters, such as locomotor activity, Morris water maze, elevated plus maze, and passive avoidance test, were assessed on days 21 and 42 of the study. The animals were euthanatized following the completion of the last behavioral assessment. Various oxidative stress parameters were assessed to know the extent of oxidative damage to brain tissue. Quercetin with memantine has shown significant improvement in behavioral studies, inhibition of AChE activity, and reduction in oxidative stress parameters. Histopathological studies assessed for cortex and hippocampus using hematoxylin and eosin (H&E), and Congo red stain demonstrated a reduction in amyloid-β plaque formation after treatment of quercetin with memantine. Immunohistochemistry showed that quercetin with memantine treatment also improved the expression of brain-derived neurotrophic factor (BDNF) and inhibited amyloid-β plaque formation. The present study results demonstrated protective effects of treatment of quercetin with memantine in the neurotoxicity linked to aluminum chloride in albino Wistar rats .

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Quercetin and its role in biological functions: an updated review

Cited by 35 publications

References 66 publications

Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer

Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer

Flavonoids against non-physiologic inflammation attributed to cancer initiation, development, and progression—3PM pathways

Neuroprotective Effect of Quercetin and Memantine against AlCl3-Induced Neurotoxicity in Albino Wistar Rats

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