Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer

Oršolić, Nada; Jembrek, Maja Jazvinšćak

doi:10.3390/ijms231810479

Cited by 36 publications

(35 citation statements)

References 419 publications

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“…Accumulating evidence suggests that TME, including cancer cells and immune cells, supports tumor growth and evasion (19,20) . Several studies have pointed to the critical task carried out by CD39 in generating this immunosuppressive environment (21,22) .…”

Section: Discussionmentioning

confidence: 99%

Spatial distribution of PD-1+CD39+CD8+ T cell in TME refined its tumorigenic and immunotherapeutic biomarker in lung cancer

Zhai

Zhang

Wang

et al. 2022

Preprint

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Purpose CD8 + T cells in tumors are heterogenous and comprise multiple differentiation states. It has been reported that human tumor-infiltrating CD8 + T cells can express CD39 and more evidences proposed CD39 as a marker of exhausted and tumor reactive CD8 + T cells. However, no studies have delved into the spatial distribution of the CD39 + CD8 + T cell subsets in lung cancer, which could help to evaluate the immune microenvironment for developing the future immunotherapy approaches. Methods A total of 53 lung cancer patients prior to any therapy were included. A subset of tumor-infiltrating CD8 + T cells marked by expression of the immunosuppressive ATP ecto-nucleotidase CD39 and PD-1 was analyzed. Neoplasm-superficial biopsy and intratumoral EBUS-TBNA were used to assess the peripheral and central tumor microenvironment respectively. Results The CD39 + CD8 + T cells were ubiquitously infiltrated in lung cancer tissue, as well as dominantly accumulated in peritumoral compartment of larger tumor. In comparison to their CD39- counterparts, CD39 + CD8 + T cells from both sites showed significantly higher expression of PD-1 in line with co-distribution of PD-1 + CD8 + T cell in TME of lung cancer. Particularly, most of CD39 + CD8 + T cells located at peripheral TME exhibited an exhausted phenotype compatible with PD-1 expression in contrast to the reported center of tumor. Furthermore, compared with CD39 + CD8 + T cells, PD-1 + CD39 + CD8 + T cells act as a better biomarker to predict response to anti-PD-1 therapy. Conclusion Spatial heterogeneity may be critical to elicit CD39 expression on lung cancer associated CD8 + T cells. More increased of PD-1 + CD39 + CD8 + T cells within peripheral TME constitute tumorigenic role and act as a candidate biomarker for immunotherapy to lung cancer.

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Section: Discussionmentioning

confidence: 99%

Spatial distribution of PD-1+CD39+CD8+ T cell in TME refined its tumorigenic and immunotherapeutic biomarker in lung cancer

Zhai

Zhang

Wang

et al. 2022

Preprint

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“…Propolis reduces oxidative stress in wounds by inducing the expression of antioxidant related genes (hemeoxygenase-1 (HO-1), glutamate-cysteine ligase- modifier GCLM and- catalytic GCLC subunits) and improves collagen expression and cell viability on cells exposed to high levels of oxidative stress. It was also demonstrated that propolis and some of its active substances have a pronounced cytostatic [ 64 , 65 , 66 , 67 , 68 ] anticarcinogenic and antitumor effect both in in vitro and in vivo tumor models [ 64 , 65 , 66 , 67 , 68 ]. Honeybee propolis and its components (CA, CAPE, artepilin C, quercetin, naringenin, resveratrol, galangin, genistein and other) are the most promising as antitumor and anti-inflammatory agents [ 5 , 57 , 58 , 64 , 65 , 66 , 67 , 68 ].…”

Section: Botanical Sources Of Propolismentioning

confidence: 99%

“…It was also demonstrated that propolis and some of its active substances have a pronounced cytostatic [ 64 , 65 , 66 , 67 , 68 ] anticarcinogenic and antitumor effect both in in vitro and in vivo tumor models [ 64 , 65 , 66 , 67 , 68 ]. Honeybee propolis and its components (CA, CAPE, artepilin C, quercetin, naringenin, resveratrol, galangin, genistein and other) are the most promising as antitumor and anti-inflammatory agents [ 5 , 57 , 58 , 64 , 65 , 66 , 67 , 68 ]. This strategy opens a new venue for cancer prevention to cancer treatment as well as treatment of numerous diseases associated with oxidative stress and inflammation, including allergy diseases.…”

Section: Botanical Sources Of Propolismentioning

confidence: 99%

“…Thus, lipoxygenase plays a decisive role in pathological processes, such as inflammation or allergies [ 54 , 55 , 56 , 70 , 71 , 125 , 126 ]. Moreover, certain enzymatic products of lipoxygenases are thought to be essential for tumorigenesis [ 65 ]. The attracted neutrophils at the site of inflammation produce superoxide via respiratory burst by their NADPH oxidase.…”

Section: Role Of Propolis and Its Components In Allergymentioning

confidence: 99%

“…Flavonoids have powerful antioxidant properties in vitro and in vivo and are able to scavenge a wide range of reactive oxygen, nitrogen, and chlorine species, such as superoxide, hydroxyl radical, peroxyl radicals, hypochlorous acid, and peroxynitrous acid ( Table 9 ). Flavonoids can also chelate metal ions, often resulting in decreased prooxidant activity of metal ions [ 55 , 56 , 65 , 70 , 71 , 96 , 101 , 120 , 136 ].…”

Section: Role Of Propolis and Its Components In Allergymentioning

confidence: 99%

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Allergic Inflammation: Effect of Propolis and Its Flavonoids

Oršolić

2022

Molecules

Self Cite

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The incidence of allergic diseases and their complications are increasing worldwide. Today, people increasingly use natural products, which has been termed a “return to nature”. Natural products with healing properties, especially those obtained from plants and bees, have been used in the prevention and treatment of numerous chronic diseases, including allergy and/or inflammation. Propolis is a multi-component resin rich in flavonoids, collected and transformed by honeybees from buds and plant wounds for the construction and adaptation of their nests. This article describes the current views regarding the possible mechanisms and multiple benefits of flavonoids in combating allergy and allergy-related complications. These benefits arise from flavonoid anti-allergic, anti-inflammatory, antioxidative, and wound healing activities and their effects on microbe-immune system interactions in developing host responses to different allergens. Finally, this article presents various aspects of allergy pathobiology and possible molecular approaches in their treatment. Possible mechanisms regarding the antiallergic action of propolis on the microbiota of the digestive and respiratory tracts and skin diseases as a method to selectively remove allergenic molecules by the process of bacterial biotransformation are also reported.

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MT1‐MMP and TIMP‐2 are first expressed in the colon glands after a single dose of azoxymethane (AOM)

da Silva,

Freitas,

do Carmo

et al. 2023

The Anatomical Record

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Tissue inhibitor of metalloproteinase‐2 (TIMP‐2) and membrane‐type 1‐matrix metalloproteinase (MT1‐MMP) are always expressed during the cancer process. The aim was to identify which regions of the colon mucosa MT1‐MMP and TIMP‐2 begin to express themselves, as well as to establish their expression in relation to cell proliferation and mucin production. After intraperitoneal injection of 15 mg/kg of azoxymethane (AOM) at 4, 12, and 20 weeks, histological sections of the middle segment of the rat colon mucosa were evaluated by immunohistochemistry for cell proliferation and expression of MT1‐MMP and TIMP‐2 and histochemistry for mucin. As a result, a single dose of AOM initially increased the intensity of MT1‐MMP and TIMP‐2 expression in the conjunctive cells and glands, concurrently with alterations in the distribution of the mucin produced in the gland of the large intestine mucosa and cell proliferation. As a result, at 4 and 12 weeks, a single dose of AOM initially stimulated the expression of MT1‐MMP and TIMP‐2 in the conjunctive cells and glands with greater intensity. Changes in the cell proliferation and distribution of the mucin produced in the large intestine mucosa gland were observed. We conclude that MT1‐MMP and TIMP‐2 were first and strongly expressed in all cells of the colon glands, concurrently with an increase in cell proliferation and a diffuse dispersion of mucin, indicating the onset of the dysplasia process following a single dosage of AOM.

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Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer

Cited by 36 publications

References 419 publications

Spatial distribution of PD-1+CD39+CD8+ T cell in TME refined its tumorigenic and immunotherapeutic biomarker in lung cancer

Spatial distribution of PD-1+CD39+CD8+ T cell in TME refined its tumorigenic and immunotherapeutic biomarker in lung cancer

Allergic Inflammation: Effect of Propolis and Its Flavonoids

MT1‐MMP and TIMP‐2 are first expressed in the colon glands after a single dose of azoxymethane (AOM)

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