In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain

Abstract

Neuropathic pain is a common symptom and is associated with an impaired quality of life. It is caused by the lesion or disease of the somatosensory system. Neuropathic pain syndromes can be subdivided into two categories: central and peripheral neuropathic pain. The present review highlights the peripheral neuropathic models, including spared nerve injury, spinal nerve ligation, partial sciatic nerve injury, diabetes-induced neuropathy, chemotherapy-induced neuropathy, chronic constriction injury, and related conditions. The drugs which are currently used to attenuate peripheral neuropathy, such as antidepressants, anticonvulsants, baclofen, and clonidine, are associated with adverse side effects. These negative side effects necessitate the investigation of alternative therapeutics for treating neuropathic pain conditions. Flavonoids have been reported to alleviate neuropathic pain in murine models. The present review elucidates that several flavonoids attenuate different peripheral neuropathic pain conditions at behavioral, electrophysiological, biochemical and molecular biological levels in different murine models. Therefore, the flavonoids hold future promise and can be effectively used in treating or mitigating peripheral neuropathic conditions. Thus, future studies should focus on the structure-activity relationships among different categories of flavonoids and develop therapeutic products that enhance their antineuropathic effects.

Exploring the Promise of Flavonoids to Combat Neuropathic Pain: From Molecular Mechanisms to Therapeutic Implications

“…Moreover, kaempferol decreased advanced glycation end products and epigallocatechin gallate (EGCG) causes a reduction of 8-hydroxy-2-deoxyguanosine, which is considered as the major form of free radical-mediated oxidative stress in the nucleus and mitochondria (Valavanidis et al, 2009). It has also been found that in the diabetic animal model, genistein and naringenin raised nerve growth factor (NGF) in sciatic nerves (Basu and Basu, 2020). Therefore, NGF servesas the survival and life maintenance of the neurons.…”

“…Conversely, these treatments cause a 30-50% decline in pain and are frequently restricted owing to their noticeable adverse effects, with dominant sedative action. Nowadays, natural products like plant secondary metabolites are widely used to treat several chronic diseases due to their limited adverse effects as well as high efficacy (Uddin et al, 2018bBegum et al, 2019;Samsuzzaman et al, 2019;Thangapandiyan et al, 2019;Basu and Basu, 2020). Flavonoids are a broad group of secondary metabolites, extensively found in many fruits, vegetables, wine, cocoa, and tea (Chun et al, 2007;Egert and Rimbach, 2011).…”

Менеджмент Хронической Постпроцедурной Боли В Стоматологии

“…Нейропатичний біль виникає внаслідок прямого пошкодження або захворювання, що впливає на соматосенсорну систему, яка складається з периферичних волокон (мієлінізованих A та A і немієлінізованих C) і центральних нейронів [8]. Часто цей біль пов'язаний із травмою або дисфункцією периферичної нервової системи, яка врешті-решт впливає на центральну нервову систему (ЦНС).…”

ALIAmides Update: Palmitoylethanolamide and Its Formulations on Management of Peripheral Neuropathic Pain

“…The International Association for the Study of Pain (IASP) describes pain as "an unpleasant sensory and emotional experience that is associated with real or probable tissue damage, as defined in rapports of such injury" [1]. Although it is easy to conceptualize pain as a homogeneous entity, in reality there are several different types, each with distinct neurobiological and pathophysiological mechanisms.…”