Quantitative imaging of arsenic and its species in goat following long term oral exposure

Effect of vitamin E supplementation on arsenic induced alteration in blood biochemical profile, oxidant/antioxidant status, serum cortisol level and retention of arsenic and selenium in goats

“…It binds with the thiol group of enzymes and proteins present in the hepatic cells, thereby, disfunctioning the hepatocytic plasma membrane leading to increased AST and ALT activity [29]. Similar to the present experiment, increased AST and ALT activity on arsenic exposure has also been reported in goats [17,30,31], sheep [32] and cattle [33]. Supplementation of 250 IU vitamin E/ kg diet was able to improve these transaminases as it protects free radicals responsible for oxidative stress; thereby inhibiting the production of ROS.…”

“…Furthermore, the evidence of moderate to high arsenic residues in the muscles and other edible tissues represent a potential public health hazard. Arsenic contents of feed and tissues also had a strong positive correlation in animal models [31,49]. Similar to our finding, elevated residual arsenic concentration in tissues was observed in the arsenic exposed rats [50,51] A c c e p t e d M a n u s c r i p t 14 in arsenic and arsenic + vitamin E supplemented kids as observed in our earlier study [54].…”

Hepatoprotective activity of Tephrosia purpurea against arsenic induced toxicity in rats

“…The increased levels of hepatic serum enzymes can be corroborated with the earlier reports. [15] Lower activity of serum enzymes in Tephrosia purpurea treated group was probably due to the presence of flavonoids[16] that produces hepatocellular membrane stability, prevention of cellular leakage and increasing hepatic regeneration. Liver is the main site of synthesis of proteins, therefore hepatic damage caused by arsenic leads to decrease in the levels of serum total protein in group treated only with NaAsO 2 .…”

“…[3] Generally arsenic undergoes hepatic biomethylation to monomethylarsonic acid and dimethylarsinic acids and are potent inhibitors if GSH reductase and causes hepatotoxicity in human and animals. [4]…”

Nephrotoxic Effects of Arsenic in Albino Mice

“…Arsenic has an affinity toward the SH group of proteins [3] that leads to inhibition of cellular respiration, impaired glycolysis and oxidative process [4] and finally death of cells. Though almost all the systems are being affected, liver and kidneys are most susceptible to arsenic toxicity [5].…”