Quantitative HPTLC analysis of phenylpropanoids in<i>Rhodiola</i>species

Rumalla, Chidananda Swamy; Avula, Bharathi; Ali, Zulfıqar; Smillie, Troy J.; Filion, Vicky; Cuerrier, Alain; Arnason, John T.; Khan, Ikhlas A.

doi:10.1556/jpc.24.2011.2.6

Cited by 4 publications

(5 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Salidroside and p ‐tyrosol have been previously reported in R. rosea , R. kirilowii , 20–22,27,47,48 R. crenulata and other Rhodiola species 24,25,49 . However, rosavins accumulation is restricted among the Rhodiola species and has been reported in R. rosea , 20,22,27 R. quadrifida and R. sachalinensis 33,35 . Recent studies from Han et al 25 reported the presence of rosavins in R. crenulata , unambiguously identified using ultra‐performance liquid chromatography (UPLC)‐Fourier transform‐ion cyclotron resonance mass spectrometry.…”

Section: Resultsmentioning

confidence: 96%

“…For example R. rosea from Poland contained 0.4% salidroside and 2.8% rosavin; from Mongolia 1.31% and 1.87%, respectively, while R. rosea from Sweden synthesised 5.07% rosavin and no salidroside was reported 33 . Rhodiola rosea from different areas of China contained 0.13–1.11% salidroside; 51 from the United States 0.24% rosarin, 0.42% rosavin and 0.06% rosin 35 . Rhodiola rosea collected from Göstling Alps, Austria had the respective amounts of 2.73% salidroside, 2.64% rosavin, 0.27% rosarin and 0.15% rosin 52 .…”

Section: Resultsmentioning

confidence: 99%

“…and R. yunnanensis (Franch.) S. H. Fu 19,32–34 or rosavin, such as R. crenulata , R. quadrifida , and R. sachalinensis 25,33,35 …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Authenticity and quality evaluation of different Rhodiola species and commercial products based on NMR‐spectroscopy and HPLC

Marchev

Koycheva

Aneva

et al. 2020

Phytochemical Analysis

View full text Add to dashboard Cite

Introduction: The main concern regarding the authenticity and quality of Rhodiola rosea L. (Sedum rosea (L.) Scop.) products is their adulteration with other Rhodiola species. Objective: The aim of the study was the development of a reliable and practical analytical platform for quality and quantity assessment of the characteristic molecules in three Rhodiola species (R. rosea, R. kirilowii (Regel) Maxim and R. crenulata (Hook. f. & Thomson) H. Ohba), commercial products and their possible application as markers for the authentication of R. rosea based products. Material and Methods: The major molecules were identified by one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR)-based metabolomics and quantitatively determined by high-performance liquid chromatography ultraviolet (HPLC-UV) analysis. The orthogonal projections to latent structures discriminant analysis (OPLS-DA) revealed the specific patterns in the metabolite profiles of R. rosea and R. crenulata. Results: The coumarin crenulatin was only identified in R. crenulata and can be used as a marker to detect potential adulteration of the commercial products. Crenulatin was identified in two of the four analysed products by NMR-spectroscopy. According to the HPLC data, in less than a quarter of all products, the labelled amounts of salidroside and total rosavins were confirmed. Conclusions: The developed analytical platform was found to be useful in the investigations of the phytochemical diversity of different Rhodiola species, the recognition of the unique metabolites between them and the identification of adulterated products. Therefore, this approach could be applied from the earliest to the latest stages of the value chain in the manufacturing of R. rosea based products.

show abstract

Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Authenticity and quality evaluation of different Rhodiola species and commercial products based on NMR‐spectroscopy and HPLC

Marchev

Koycheva

Aneva

et al. 2020

Phytochemical Analysis

View full text Add to dashboard Cite

show abstract

“…HPTLC has been used to both quantitatively and qualitatively evaluate several botanical species such as Caulophyllum thalictroides (L.) Michx., Morus spp., Lonicera japonica Thunb., Lancea tibetica Hook. f. & Thomson, and Rhodiola spp . Figure illustrates how HPTLC can provide a snapshot profile of authentic samples of Rhodiola spp.…”

Section: Authentication Of Botanicalsmentioning

confidence: 99%

“…f. & Thomson, 73 and Rhodiola spp. 74 Figure 6 illustrates how HPTLC can provide a snapshot profile of authentic samples of Rhodiola spp. as well as commercial products claiming to contain Rhodiola spp.…”

Section: ■ Authentication Of Botanicalsmentioning

confidence: 99%

Implementing a “Quality by Design” Approach to Assure the Safety and Integrity of Botanical Dietary Supplements

Khan

Smillie

2012

J. Nat. Prod.

Self Cite

View full text Add to dashboard Cite

Natural products have provided a basis for health care and medicine to humankind since the beginning of civilization. According to the World Health Organization (WHO), approximately 80% of the world population still relies on herbal medicines for health-related benefits. In the United States, over 42% of the population claimed to have used botanical dietary supplements to either augment their current diet or to "treat" or "prevent" a particular health-related issue. This has led to the development of a burgeoning industry in the U.S. ($4.8 billion per year in 2008) to supply dietary supplements to the consumer. However, many commercial botanical products are poorly defined scientifically, and the consumer must take it on faith that the supplement they are ingesting is an accurate representation of what is listed on the label, and that it contains the purportedly "active" constituents they seek. Many dietary supplement manufacturers, academic research groups, and governmental organizations are progressively attempting to construct a better scientific understanding of natural products, herbals, and botanical dietary supplements that have co-evolved with Western-style pharmaceutical medicines. However, a deficiency of knowledge is still evident, and this issue needs to be addressed in order to achieve a significant level of safety, efficacy, and quality for commercial natural products. The authors contend that a "quality by design" approach for botanical dietary supplements should be implemented in order to ensure the safety and integrity of these products. Initiating this approach with the authentication of the starting plant material is an essential first step, and in this review several techniques that can aid in this endeavor are outlined.

show abstract