Phytochemical variations of Rhodiola rosea L. wild-grown in Bulgaria

Marchev, Andrey S.; Aneva, Ina; Koycheva, Ivanka K.; Georgiev, Milen I.

doi:10.1016/j.phytol.2016.12.030

Cited by 28 publications

(27 citation statements)

References 16 publications

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“…Across all ASE extracts, cinnamyl alcohol glycoside composition showed to be rosavin > rosarin > rosin. This was previously reported for underground parts of wild-grown Rhodiola rosea from Bulgaria [31]. Concerning ethanolic maceration, 96% ethanol proved to be the preferable solvent to achieve higher content of salidroside, cinnamyl alcohol glycosides and flavonoids, although variation was high between extracts, especially for salidroside.…”

Section: Discussionsupporting

confidence: 67%

“…Freeze-drying of plant material before longer transportation could reduce these hydrolysis effects. As reported in earlier studies [31,32], it was found that phytochemical contents of Rhodiola rosea are highly dependent on individual plants and geographical area. Selection of plants showing favorable traits seems to be most promising for cultivation.…”

Section: Discussionsupporting

confidence: 62%

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Qualitative and Quantitative Analysis of Different Rhodiola rosea Rhizome Extracts by UHPLC-DAD-ESI-MSn

et al. 2019

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Rhodiola rosea has been used in folk medicine as ethanolic macerates for a long time. This study aims to provide a quantitative and qualitative analysis and comparison of different ethanolic Rhodiola rosea rhizome macerates (35%, 70%, and 96% v/v) and accelerated solvent extraction (ASE) extracts prepared with 85% methanol, in order to shed light on the effectivity of different extraction methods. Extract samples were analyzed by UHPLC-DAD-ESI-MS n on a ZORBAX SB-C18 column (100 × 2.1 mm, 1.8 µm) with a mobile phase consisting of water + 0.1% formic acid and acetonitrile. Qualitative analysis lead to the tentative identification of 18 compounds: Two cyanogenic glycosides (rhodiocyanoside A, lotaustralin), three phenylethanoids (salidroside, viridoside, 2-phenylethyl-vicianoside), two procyanidin and catechin derivatives (epigallocatechin-epigallocatechin gallate, epigallocatechin-3-O-gallate), five phenylpropanoids (cinnamyl alcohol, rosarin, rosavin, rosin, cinnamyl-(6'-O-β-d-xylopyranosyl)-O-β-glucopyranoside), two monoterpene alcohols (rhodioloside E, rosiridin) and four flavonols (rhodionidin, rhodiosin, rhodionin, kaempferol). Quantity was determined for salidroside, cinnamyl alcohol and its three major glycosides (rosarin, rosavin, rosin), as well as three flavonols (rhodionidin, rhodiosin, rhodionin). Methanolic ASE proved to be the superior extraction method for different substance groups. For macerates, high ethanol content increased yield and lowered hydrolysis of glycosides during extraction, but ethanolic macerates still showed low reproducibility and high fluctuations in quantity of marker compounds salidroside and rosavins, as well as flavonols. Rhodiola rosea rhizomes of wild origins seemed to underly great variability in chemical composition dependent on grow site.

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Section: Discussionsupporting

confidence: 67%

Section: Discussionsupporting

confidence: 62%

Qualitative and Quantitative Analysis of Different Rhodiola rosea Rhizome Extracts by UHPLC-DAD-ESI-MSn

et al. 2019

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“…The NMR-based metabolomics is an useful tool in terms of quality control, since it allows obtaining structural information for a wide range of compounds in complex plant extracts or commercial products with a high analytical precision (Georgiev et al, 2015). This technique has been successfully applied in development of procedures for detection of marker phytochemicals found in a definite plant or commercial product, thus confirming their authenticity (Booker et al, 2016;Marchev et al, 2017a).…”

Section: Clinical Studiesmentioning

confidence: 99%

Causes and solutions to “globesity”: The new fa(s)t alarming global epidemic

Vasileva

Marchev

Georgiev

2018

Food and Chemical Toxicology

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Diverse groups of factors are leading to increased weight gain and obesity, such as certain genetic phenotypes, neuroendocrine disturbances, the administration of some drugs, behavioral, social and environmental factors. The progressively escalating rates of overweight and obesity worldwide have led to an introduction of a new term "globesity". Excessive accumulation of body fat and especially of visceral adipose tissue is the main predisposing factor for the development of metabolic syndrome and other obesity related co-morbidities. At the present moment only few pharmacotherapeuticals are used for long-term treatment of obesity acting on narrow target spectra, e.g. pancreatic and gastric lipase inhibition, acting as adrenomimetics or activating the satiety centers in hypothalamus. Plant-based medications that accelerate weight loss, proved to be safe, effective and widely available, would be a preferable alternative for anti-obesity treatments. As plant extracts are multi-component systems they could also act by more than one mechanism, including decreased lipid absorption, decreased energy intake, increased energy expenditure, decreased pre-adipocyte differentiation and proliferation, decreased lipogenesis and increased lipolysis. The current review gives a summary of the risk factors for obesity development and its characteristics consequences. Current treatment options, combining lifestyle changes and conventional treatment with commercial anti-obesity drugs have been described as well. Special emphasis on in vitro, in vivo and human studies, of potential medicinal plant extracts and phytochemicals, such as polyphenols, terpenoids, alkaloids, saponins, able to modulate the molecular pathways and gene/protein expressions related to obesity, have been highlighted.

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“…More than 150 biologically active compounds have been identified in R. rosea [6,8,[13][14][15]. They belong to derivatives of alkanols, benzyl and phenols, phenylethanes, gallic acid, phenylpropanoids, flavonoids, monoterpenoids, triterpenes, and others [13,[15][16][17][18][19][20]. Among the other phenyletanes is tyrosol (a) and its derivative salidroside (b), phenylpropanoids: cinnamyl alcohol (c), its glycosides rosin (d), and rosavin (e), which are believed to be the most important markers of R. rosea and are responsible for its pharmacological activity ( Figure 1) [2,10,11,19,21].…”

Section: Introductionmentioning

confidence: 99%

Natural Deep Eutectic Solvents for the Extraction of Phenyletanes and Phenylpropanoids of Rhodiola rosea L.

Shikov

Косман²,

Flissyuk

et al. 2020

Molecules

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The extraction of Rhodiola rosea rhizomes using natural deep eutectic solvent (NADES) consisting of lactic acid, glucose, fructose, and water was investigated. A two-level Plackett-Burman design with five variables, followed by the steepest ascent method, was undertaken to determine the optimal extraction conditions. Among the five parameters tested, particle size, extraction modulus, and water content were found to have the highest impact on the extrability of phenyletanes and phenylpropanoids. The concentration of active compounds was analyzed by HPLC. The predicted results showed that the extraction yield of the total phenyletanes and phenylpropanoids (25.62 mg/g) could be obtained under the following conditions: extraction time of 154 min, extraction temperature of 22 • C, extraction modulus of 40, molar water content of 5:1:11 (L-lactic acid:fructose:water, mol/mol), and a particle size of rhizomes of 0.5-1 mm. These predicted values were further verified by validation experiments in predicted conditions. The experimental yields of salidroside, tyrosol, rosavin, rosin, cinnamyl alcohol and total markers (sum of phenyletanes and phenylpropanoids in mg/g) were 11.90 ± 0.02, 0.36 ± 0.02, 12.23 ± 0.21, 1.41 ± 0.01, 0.20 ± 0.01, and 26.10 ± 0.27 mg/g, respectively, which corresponded well with the predicted values from the models.

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Phytochemical variations of Rhodiola rosea L. wild-grown in Bulgaria

Cited by 28 publications

References 16 publications

Qualitative and Quantitative Analysis of Different Rhodiola rosea Rhizome Extracts by UHPLC-DAD-ESI-MSn

Qualitative and Quantitative Analysis of Different Rhodiola rosea Rhizome Extracts by UHPLC-DAD-ESI-MSn

Causes and solutions to “globesity”: The new fa(s)t alarming global epidemic

Natural Deep Eutectic Solvents for the Extraction of Phenyletanes and Phenylpropanoids of Rhodiola rosea L.

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