Quantitative EEG mapping and PET in Alzheimer's disease

Szelies, B.; Grond, Martin; Herholz, Karl; Kessler, Joseph; Wullen, T.; Heiss, Wolf‐Dieter

doi:10.1016/0022-510x(92)90008-9

Cited by 87 publications

(51 citation statements)

References 38 publications

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“…A previous study (d 'Onofrio et al, 1996) has shown a slowing in the beginning of alpha frequency in vascular demented subjects that fits our findings, although the mentioned study was carried out using fixed but not individual frequency bands. Furthermore, these results are in line with previous evidence showing that lesions of the white matter in VaD were directly related to a widespread slowing of EEG rhythmicity (Szelies et al, 1992(Szelies et al, , 1999. The white matter lesions of multiple sclerosis also decreased the frequency of the alpha rhythm (Leocani et al, 2000), while successful immunosuppressive treatment, probably restoring appropriate nerve propagation, resulted in recovery of normal alpha frequency without effects on the relative power (Colon et al, 1981).…”

Section: Relative Power and Frequency Of Alpha Rhythms In Mild Dementiasupporting

confidence: 90%

“…These findings are considered indirect evidence of the fundamental role of cholinergic system in modulating alpha rhythms, given the well-known selective deficit of acetylcholine occurring from the earliest stages of AD. However, the typical 'slowing' of EEG rhythms seen in AD (Coben et al, 1983(Coben et al, , 1990Sloan et al, 1995) has also been reported in vascular dementia (VaD; Szelies et al, 1992).…”

Section: Introductionmentioning

confidence: 90%

“…Quantitative analysis of electroencephalographic (EEG) rhythms in resting subjects is a low-cost and potentially useful neurophysiological approach to the study of normal aging and dementia (Gueguen et al, 1991;Maurer and Dierks, 1992;Szelies et al, 1992;Leuchter et al, 1993;Schreiter-Gasser et al, 1993;Bennys et al, 2001). This type of analysis includes the estimation of the power density of selected EEG frequency bands (AD; Besthorn et al, 1997;Chiaramonti et al, 1997;Schreiter-Gasser et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

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Individual analysis of EEG frequency and band power in mild Alzheimer's disease

Moretti

Babiloni

Binetti

et al. 2004

Clinical Neurophysiology

325

251

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Objective: This EEG study investigates the role of the cholinergic system, cortico-cortical connections, and sub-cortical white matter on the relationship between individual EEG frequencies and their relative power bands.Methods: EEGs were recorded at rest in 30 normal elderly subjects (Nold), 60 mild Alzheimer disease (AD) and 20 vascular dementia (VaD) patients, comparable for Mini Mental State Evaluation scores . Individual EEG frequencies were indexed by the theta/alpha transition frequency (TF) and by the individual alpha frequency (IAF) with power peak in the extended alpha range (5 -14 Hz). Relative power was separately computed for delta, theta, alpha1, alpha2, and alpha3 bands, on the basis of the TF and IAF.Results: Using normal subjects as a reference, VaD patients showed 'slowing' of alpha frequency (TF-IAF) and lower alpha2 power; Mild AD patients showed lower alpha2 and alpha3 power; delta power was higher in both AD and VaD patients; Theta power was higher only in VaD patients.Conclusions: Individual analysis of the alpha frequency and power can discriminate mild AD from VaD and normal elderly subjects.Significance: This analysis may probe pathophysiological mechanisms causing AD and VaD.

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Section: Relative Power and Frequency Of Alpha Rhythms In Mild Dementiasupporting

confidence: 90%

Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Individual analysis of EEG frequency and band power in mild Alzheimer's disease

Moretti

Babiloni

Binetti

et al. 2004

Clinical Neurophysiology

325

251

View full text Add to dashboard Cite

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“…In fact, a theoretical model considering a mean speed propagation in white matter fibers of 7.5 m/s (together with other parameters) is associated with a fundamental mode frequency of 9 Hz (Nunez, 1995;Nunez and Srinivasan, 2006), that is, the typical mode of scalp-recorded EEG. It is to be noted that a correlation between white matter damage and widespread slowing of EEG rhythmicity was found in other studies, following the presence of cognitive decline (d'Onofrio et al, 1996;Szelies et al, 1992Szelies et al, , 1999, multiple sclerosis (Leocani et al, 2000), or cerebral tumors (Gloor et al, 1977;Goldensohn, 1979). In the present study, we found neither impact of vascular damage on the IAF, nor significant correlation between CV damage score and IAF.…”

Section: Eeg Frequency Indices Of a Rhythms And CV Damagementioning

confidence: 64%

Vascular damage and EEG markers in subjects with mild cognitive impairment

Moretti

Miniussi

Frisoni

et al. 2007

Clinical Neurophysiology

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Objective: We evaluated the changes induced by cerebrovascular (CV) damage on brain rhythmicity recorded by electroencephalography (EEG) in a cohort of subjects with mild cognitive impairment (MCI). Methods: We enrolled 99 MCI subjects (Mini-Mental State Examination [MMSE] mean score 26.6). All subjects underwent EEG recording and magnetic resonance imaging (MRI). EEGs were recorded at rest. Individual EEG frequencies were indexed by the h/a transition frequency (TF) and by the individual a frequency (IAF) with power peak in the extended a range (5-14 Hz). Relative power was separately computed for d, h, a1, a2, and a3 frequency bands on the basis of the TF and IAF values. Subsequently, we divided the cohort in four sub-groups based on subcortical CV damage as scored by the age-related white matter changes scale (ARWMC). Results: CV damage was associated with 'slowing' of TF proportional to its severity. In the spectral bandpower the severity of vascular damage was associated with increased d power and decreased a2 power. No association of vascular damage was observed with IAF and a3 power. Moreover, the h/a1 ratio could be a reliable index for the estimation of the individual extent of CV damage. Conclusions: EEG analysis may show physiological markers sensitive to CV damage. The appropriate use of this EEG index may help the differential diagnosis of different forms of cognitive decline, namely primary degenerative and secondary to CV damage. Significance: The EEG neurophysiological approach, together with anatomical features from imaging, could be helpful in the understanding of the functional substrate of dementing disorders.

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“…Já Sloam e col. 14 mostraram achados congruentes entre a análise de coerência do EEG e pela tomografia por emissão de pósitron único (SPECT). Resultados semelhantes foram obtidos por Szelies e col. 15 ao comparar EEG quantitativo (EEGQ) a tomografia por emissão de pósitrons (PET).…”

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Estudo da coerência do eletrencefalograma para a banda de frequência alfa em indivíduos adultos normais e com provável demência do tipo Alzheimer

Anghinah

Kanda

Jorge

et al. 2000

Arq. Neuro-Psiquiatr.

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RESUMO -Estudamos a coerência inter-hemisférica do espectro do eletrencefalograma (EEG) obtido pela transformada rápida de Fourier, da região occipital do escalpo (eletrodos O1 e O2) para a banda de frequência alfa (alfa 1 -8,0 a 10,0 Hz e alfa 2 -10,1 a 12,5 Hz) em indivíduos normais maiores de 50 anos e pacientes com diagnóstico provável de demência do tipo Alzheimer (DTA), no intuíto de observar se há diferenças entre estes parâmetros que contribuam com o diagnóstico desta enfermidade. Encontramos diminuição na coerência interhemisférica dos indivíduos com DTA para ambas as sub-bandas do ritmo alfa. Acreditamos que a análise de coerência do EEG possa ser um método de grande auxílio no diagnóstico de DTA.PALAVRAS-CHAVE: eletrencefalograma quantitativo, análise de coerência, demência. Alpha band coherence analysis of EEG in healthy adult and Alzheimer's type dementia subjectsABSTRACT -We studied the occiptal inter-hemispheric coherence (IHCoh) of EEG (electrodes O1-O2) for alpha band (alpha 1 -8,0 to 10,0 Hz and alpha 2 -10,1 to 12,5 Hz) in healthy adults and Alzheimer's type dementia (ATD) subjects, to observe if there is any significant difference between these two groups that could help in the early diagnosis of ATD. We found a decrease of occipital IHCoh in ATD group for both alpha sub-bands. We believe that Coh analysis of EEG is a powerful auxiliary method in ATD diagnosis.KEY WORDS: quantitative electroencephalography, coherence analysis, dementia.Coerência (Coh) é a medida da covariância do espectro de dois sinais de eletrencefalograma (EEG). A alta Coh entre dois sinais do EEG tem sido considerada como evidência estrutural e funcional da ocorrência de conexões entre áreas corticais 1 . Desde os primeiros estudos da quantificação do EEG por Lehmann (1971) 2 e Duffy e cols.. (1979) 3 o estudo da análise espectral e estatística do EEG vem sendo largamente utilizado. Contrariamente a isto, estudos da Coh do EEG são raramente encontrados na literatura 4 . A informação obtida pelo estudo da Coh é essencial para o entendimento de como relacionamentos mútuos entre regiões cerebrais podem mudar sob diferentes condições 5 .Das infinitas possibilidades de correlações entre diferentes áreas cerebrais, a análise de Coh é uma medida já estabelecida como capaz de mensurar as relações inter-hemisféricas através do corpo caloso tanto na vigília como no sono 6 .

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Quantitative EEG mapping and PET in Alzheimer's disease

Cited by 87 publications

References 38 publications

Individual analysis of EEG frequency and band power in mild Alzheimer's disease

Individual analysis of EEG frequency and band power in mild Alzheimer's disease

Vascular damage and EEG markers in subjects with mild cognitive impairment

Estudo da coerência do eletrencefalograma para a banda de frequência alfa em indivíduos adultos normais e com provável demência do tipo Alzheimer

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