Quantitative determination of oxprenolol and timolol in urine by capillary zone electrophoresis

Maguregui, Miren Itxaso; Jiménez, Roberto; Alonso, Rosa M.; Akesolo, Urtzi

doi:10.1016/s0021-9673(01)01320-6

Cited by 19 publications

(13 citation statements)

References 17 publications

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“…BP estimated Timolol Maleate potentiometrically [13]. Literature review reveals several methods have been reported for the estimation of Timolol Maleate in biological fluids [14][15][16][17][18][19] and there are some methods reported by voltammetry [20], spectroscopy [21][22][23], HPTLC [24] HPLC [25][26][27][28], UPLC [29,30] and capillary electrophoresis [31]. Two methods were only reported for estimation of this combination, the first is HPTLC [32] and the other is HPLC method [33].…”

Section: Timolol Maleate Is (2s)mentioning

confidence: 99%

Development and Validation of HPLC Method for Simultaneous Estimation of Brimonidine Tartrate and Timolol Maleate in Bulk and Pharmaceutical Dosage Form

Elshanawane¹,

Abdel‐Aziz²,

Mohram³

et al. 2014

J Chromat Separation Techniq

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Brimonidine tartrate and Timolol Maleate are used in treatment of glaucoma by decreasing intra ocular pressure. A validated HPLC method was developed for the assay of them. The method was performed on BDS HYPERSIL Cyano column (250×4.6 mm, 5 μ) and the mobile phase consisted of Ammonium acetate (pH 5.0, 0.01 M) -Methanol (40:60, V/V) which pumped at a flow rate equals to 1.5 ml/min at ambient temperature. 20 µl of drugs sample solutions were monitored at two fixed wavelengths (lambda=254.0 nm for Brimonidine Tartrate and 300.0 nm for Timolol Maleate). The proposed method was validated in terms of linearity, accuracy, precision and limits of detection and quantitation according to ICH.

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Section: Timolol Maleate Is (2s)mentioning

confidence: 99%

Development and Validation of HPLC Method for Simultaneous Estimation of Brimonidine Tartrate and Timolol Maleate in Bulk and Pharmaceutical Dosage Form

Elshanawane¹,

Abdel‐Aziz²,

Mohram³

et al. 2014

J Chromat Separation Techniq

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“…CE-based methods [46,47] were also developed but these methods were only reported for qualitative analysis. Alonso et al [48] have described a simple CZE/UV method for quantitative determination of oxprenolol and timolol in human urine. Prior to the analysis by CZE, urine samples obtained from hypertensive patients with ingestion of a therapeutic dose were first treated by SPE using Bond Elut Certify LRC SPE columns.…”

Section: Oxprenolol and Timololmentioning

confidence: 99%

Recent progress in pharmacokinetic applications of capillary electrophoresis

Lin

Chen

2003

Electrophoresis

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This review is a continuation of the previous reviews (Electrophoresis 1999, 20, 3259-3268; Electrophoresis 2001, 22, 4244-4248) to update the recent publications from 2001 to 2003 on pharmacokinetic studies using capillary electrophoresis (CE). During this period of time, CE remains as a unique analytical method for some studies, which would otherwise be limited by many factors, such as the sample volume, detection sensitivity, or separation power. It is particularly noticeable that the separation of chiral drugs in biological sample and the use of solid-phase extraction (SPE) as a simple and convenient means of sample preparation appear to become popular for CE-based assays. The use of CE for assessing complete pharmacokinetic information, however, did not show a significant growth during this period of time. In order to provide a broad range of view on how biological samples are analyzed by CE, this review will cover publications during the past two years on the use of CE for the analysis of drugs in biological fluids for general pharmacokinetic applications including drug monitoring and bioavailability studies.

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“…Literature survey revealed that few methods have been reported for the determination of TIM in pharmaceutical preparations such as spectrophotometric methods [28][29][30]. Here, also, derivative ultraviolet [31,32], high-performance liquid chromatography [33,34], liquid chromatography [35], chemiluminescence [36] and electrophoresis [37]. Timolol is officially recognised in the USP [38] and BP [39].…”

Section: Introductionmentioning

confidence: 99%

Direct Spectrophotometric Determination of Atenolol and Timolol Anti-Hypertensive Drugs

El‐Didamony

Moustafa

2017

Int J Pharm Pharm Sci

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Objective: Direct and sensitive spectrophotometric method is described for the quantitative determination of some anti-hypertensive drugs such as atenolol (ATN) and timolol (TIM) in pure forms as well as in their dosage forms. Methods:The proposed method is based on the redox reaction between the selected drugs and KMnO4 in alkaline medium. The method involves treating the aqueous solution of the selected drugs with KMnO4 in alkaline medium and measuring the bluish-green product at 610 nm. The different experimental parameters affecting the development and stability of the color were carefully studied and optimized. Results:The fixed-time method is adopted for constructing the calibration curves, which were found to be linear over the concentration ranges of 2.0-14 µg/ml and 2.0-28 µg/ml for ATN and TIM, respectively. The determination of the studied drugs by initial rate, variable time and rate constant method was workable with the calibration equations obtained but the fixed time method has been found to be more applicable. Conclusion:The applicability of the proposed method was demonstrated by the determination of the selected drugs in both pure and in commercial dosage forms and has met the validation requirements.

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Quantitative determination of oxprenolol and timolol in urine by capillary zone electrophoresis

Cited by 19 publications

References 17 publications

Development and Validation of HPLC Method for Simultaneous Estimation of Brimonidine Tartrate and Timolol Maleate in Bulk and Pharmaceutical Dosage Form

Development and Validation of HPLC Method for Simultaneous Estimation of Brimonidine Tartrate and Timolol Maleate in Bulk and Pharmaceutical Dosage Form

Recent progress in pharmacokinetic applications of capillary electrophoresis

Direct Spectrophotometric Determination of Atenolol and Timolol Anti-Hypertensive Drugs

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