Quantitative assessment of submicron scale anisotropy in tissue multifractality by scattering Mueller matrix in the framework of Born approximation

Das, Nandan; Dey, Rajib; Chakraborty, Semanti; Panigrahi, Prasanta K.; Meglinski, Igor; Ghosh, Nirmalya

doi:10.1016/j.optcom.2017.11.082

Cited by 27 publications

(25 citation statements)

References 35 publications

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“…The Stokes vector components (second and third components) deal with azimuth and ellipticity along with estimation of the polarization ellipticity through the fourth component of Stokes vector. The normal and diabetic kidney samples are well differentiated through the Stokes‐correlometry parameters dealing with phase and modulus of the polarization inhomogeneous images for the kidney samples of both type of tissue where the phase shift change is observed due to the various size of the birefringent fibrils and their curvilinearity and shows the fractal nature of the specimen. In this study, the different nature of refractive index of the biological specimen for the linear, linear‐45 and circular polarization has not taken into consideration.…”

Section: Resultsmentioning

confidence: 84%

Mapping of retardance, diattenuation and polarizance vector on Poincare sphere for diagnosis and classification of cervical precancer

Zaffar

Pradhan

2020

Journal of Biophotonics

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The mapping of diattenuation, polarizance and retardance vector (normalized Stokes vector) on Poincare sphere, evaluated from Mueller matrix of optically anisotropic stromal region of cervical tissues, is presented for cervical precancer detection and its staging. This reveals that the changes in the polarization states shown by these normalized Stokes vectors corresponds to the degradation of linearly arranged collagen fibers, breakage of the collagen cross links in the stromal region and change in the density of scattering sites when cervical cancer evolves. The distinct nature of real and imaginary parts of the refractive index for linear, linear-45 and circular polarization from the optically anisotropic stromal region underscore the various polarization structures of the connective tissue region which get modified during the pathological changes. It has been found that versatility of these vectors for normal and precancerous cervical tissue of various grades may be utilized as a key distinction for qualitative staging of cervical precancer tissue. Quantitative classification of precancerous stages of cervical precancer has been determined with 95%-100% sensitivity and 93%-100% specificity through the evaluation of linear and circular diattenuation, linear polarizance and linear birefringence from the components of the respective vectors. K E Y W O R D S cervical cancer, diattenuation vector, Mueller matrix, Poincare sphere, polarizance vector, retardance vector, stromal region

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Section: Resultsmentioning

confidence: 84%

Mapping of retardance, diattenuation and polarizance vector on Poincare sphere for diagnosis and classification of cervical precancer

Zaffar

Pradhan

2020

Journal of Biophotonics

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“…All elements of MM are real numbers, MM contains full information on polarimetric properties of the sample in the absence of non-linear effects. In the recently published studies, MM polarimetry has been applied to differentiating the polycrystalline structure of healthy and pathologically altered tissues of myocardium [13], characterization of rectum wall tissue, vaginal wall during genital prolapse, brain tissue [14], detection of healthy and pre-cancerous regions of uterine cervix tissue [15][16][17], blood films characterization for cancer diagnosis [18], detection of cancer of colorectal tissue [19,20] and characterization of other tissues [21,22]. Other polarization-based techniques, such as Stokes polarimetry based on circularly polarized illumination [23,24], Jones-matrix tomography [25,26], Stokes correlometry [27] were also widely used for the characterization of various tissues.…”

Section: Introductionmentioning

confidence: 99%

Evaluating β-amyloidosis progression in Alzheimer’s disease with Mueller polarimetry

Borovkova¹,

Bykov²,

Попов³

et al. 2020

Biomed. Opt. Express

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We applied the wide-field Mueller imaging polarimetry for the screening of formalinfixed paraffin-embedded samples of mouse brain tissue at different stages of brain β-amyloidosis in Alzheimer's disease (AD). The accumulation of amyloid-beta (Aβ) deposits throughout the brain tissue is one of the key pathological hallmarks observed with the AD progression. We demonstrate that the presence of Aβ plaques influences the properties of backscattered polarized light, in particular, its degree of depolarization. By means of statistical analysis, we demonstrate that the high-order statistical moments of depolarization distributions, acquired with the multi-spectral Mueller imaging polarimetry, can be used as sensitive markers of the growing presence of Aβ plaques. The introduced label-free polarimetric approach has a potential to facilitate the current practice of the histopathology screening in terms of diagnosis accuracy, time and cost efficiency.

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“…HE optically-based polarimetry is popular experimental approach widely used for non-invasive diagnosis of various turbid tissue-like scattering media [1][2][3][4][5][6], including those containing optically anisotropic layers [7][8][9] and fluids [10][11][12]. With the recent instrumentation developments in the field, a high sensitivity of laser polarimetry in screening of turbid cancerous biological tissues has been achieved [13][14][15][16]. The further development of this approach is based on the statistical analysis of averaged values of the polarization parameters (e.g.…”

Section: Introductionmentioning

confidence: 99%

Stokes-Correlometry Analysis of Biological Tissues With Polycrystalline Structure

Ushenko

Sdobnov

Dubolazov

et al. 2019

IEEE J. Select. Topics Quantum Electron.

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Quantitative assessment of submicron scale anisotropy in tissue multifractality by scattering Mueller matrix in the framework of Born approximation

Cited by 27 publications

References 35 publications

Mapping of retardance, diattenuation and polarizance vector on Poincare sphere for diagnosis and classification of cervical precancer

Mapping of retardance, diattenuation and polarizance vector on Poincare sphere for diagnosis and classification of cervical precancer

Evaluating β-amyloidosis progression in Alzheimer’s disease with Mueller polarimetry

Stokes-Correlometry Analysis of Biological Tissues With Polycrystalline Structure

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