Quantitative assessment of parkinsonian sialorrhea and results of treatment with botulinum toxin

Does botulinum toxin decrease frequency and severity of sialorrhea in Parkinson's disease?

“…However, 52% of our patients did not present improvement in the frequency of drooling. Previous authors observed that there is no association between decrease of saliva production and drooling due to swallowing dysfunction observed in this group of patients [1,5,6]. Our results suggest that unreduced frequency of drooling may reflect difficulties in swallowing, whereas reduction in severity may be related to a decrease of saliva production after use of BTX.…”

“…Drooling is common in several neurological diseases [1,2]. In the late course of Parkinson's disease, it is associated with increased morbidity [3].…”

Botulinum toxin type-B improves sialorrhea and quality of life in bulbaronset amyotrophic lateral sclerosis

“…Most studies performing BTX injections without ultrasound guidance did not find evidence of local diffusion into masticatory or facial muscles [4,5,8,13,14,19,27]. However, a mild transitory increase in difficulty of chewing was reported by three of our patients and one had a mild facial paralysis for 3 weeks.…”

Therapeutic uses and efficacy of botulinum toxin in orofacial medicine

“…Complementary therapies are also not completely satisfactory. The authors list many devices that can improve swallowing and tongue position [40][41][42]. Atypical swallowing is mainly related to neurological disorders caused by the previously mentioned pathologies.…”