Botulinum toxin type-B improves sialorrhea and quality of life in bulbaronset amyotrophic lateral sclerosis

Abstract

Anatomic guided BTX type B injections seem effective and safe to treat sialorrhea in bulbar-onset ALS.

Thickened saliva after effective management of drooling with botulinum toxin A

“…Incidental side-effects have been reported, such as flu-like symptoms lasting for less than 2 days, swallowing difficulties, viscous saliva and dryness of the mouth, transient slight weakness of the masseter muscle or mouth openers, and, rarely, jaw dislocation. [1][2][3][4][5][6] Human saliva serves multiple functions in the oral cavity, including moistening of food, facilitation of mastication and swallowing, and cleaning and lubrication of the oral mucosa. 7 The seromucous sublingual, submandibular, and palatine glands secrete mucins that coat and protect the epithelial tissue of the oral cavity and give the typical viscoelastic character to saliva.…”

Saliva management options for difficult-to-wean people with tracheostomy following severe acquired brain injury (ABI): A review of the literature

“…In addition to medical therapy, treatment of sialorrhoea can be accomplished with botulinum toxin (Botox Õ or Dysport Õ ) type A [19,76,[80][81][82][83] or type B [84][85][86] injections into the submandibular [19,76,[80][81][82][83][84][85][86] or parotid glands [19,76,81,82,84,85]. In Australia, Botulinum toxin type A is available, whereas Botulinum toxin type B is not.…”

Managing excessive saliva with salivary gland irradiation in patients with amyotrophic lateral sclerosis

“…One of the first is prescribing anticholinergic agents [1], which can decrease salivary production, but symptom control can often require higher doses over time, leading to undesirable side effects such as urinary retention and constipation. Alternatively, more invasive techniques may be attempted such as botulinum toxin injections directly into the salivary glands [3][4][5], which is effective, though it has been associated with several severe adverse effects, including worsening dysphagia. Finally, surgical approaches exist, such as salivary duct ligation [6] and transtympanic neurectomy [7].…”