Quantitative analysis of visual field and optic disk in glaucoma: retinal nerve fiber bundle-associated analysis

Jünemann, Anselm; Martus, Peter; Wisse, Martin; Jonas, Jost B.

doi:10.1007/s004170050357

Cited by 10 publications

(7 citation statements)

References 34 publications

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“…Interestingly, the number of regions created by our map was similar to that of the map created by Jünemann et al ,15 which comprised 10 regions and a relatively similar distribution. It derives from a functional map, originally created by Weber and Ulrich,16 which was recently modified by Jünemann et al according to the nerve fibre lines that showed a good correspondence with the anatomical course of the retinal nerve fibres.…”

Section: Discussionsupporting

confidence: 78%

The relationship between structure and function as measured by OCT and Octopus perimetry

et al. 2015

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Background/aims To determine the structurefunction relationship between equivalent visual field areas obtained with the Octopus perimeter (OP), and the peripapillary retinal nerve fibre layer (RNFL) thickness measured with spectral-domain optical coherence tomography (OCT) in healthy individuals and patients with glaucomatous optic neuropathy. Methods Eighty-eight normal subjects and 150 patients with open-angle glaucoma were prospectively recruited. Eligible participants for the glaucoma group were required to have elevated intraocular pressure and glaucomatous optic nerve head morphology. All participants underwent reliable automated perimetry with OP, and optic nerve head imaging with the Cirrus OCT. Principal component analysis of the mean threshold values for the visual field test points were performed independently for each hemifield. Pearson correlations were calculated between visual field regions and RNFL thickness sectors. Results Mild to moderate correlations were observed between the visual field regions and the peripapillary RNFL thicknesses. Each visual field region was significantly correlated with more than one RNFL sector, and vice versa. The strongest correlation was observed between the RNFL thickness at 5 and 7 clock-hour positions and the superonasal region of OP (r=0.63). Conclusions Retinal sensitivity evaluated with OP correlated moderately well with the RNFL thickness measured by OCT. There was an overlap of the visual field regions within the optic disc.

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Section: Discussionsupporting

confidence: 78%

The relationship between structure and function as measured by OCT and Octopus perimetry

et al. 2015

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“…23 In the past, the correlation between localized perimetric losses and measurements of the optic nerve was studied in corresponding sectors using parameters of the neuroretinal rim 4,8,24 and the thickness of the nerve fiber layer. 2,5,15,25,26 When comparing results of these studies, it should be considered that analyses with HRT and planimetry are based on optic disc data, whereas the results of SLP and SOCT, as used in the present study, are measured in the peripapillary region, not on the border of the optic disc.…”

Section: Discussionmentioning

confidence: 99%

“…Photographic methods as well as modern scanning laser devices have been used to measure retinal structures and to investigate the association between focal structural damages and possible losses in the corresponding visual field area (Garway-Heath DF, et al IOVS 2003;44:ARVO E-Abstract 980). 1,2,8 A matter of particular interest is the topographic association between glaucomatous scotomas and losses in the course of the nerve fiber layer bundles. 9,10 Retinal nerve fiber layer (RNFL) thickness can be measured with optical coherence tomography (OCT) and scanning laser polarimetry (SLP).…”

mentioning

confidence: 99%

Correlation between Local Glaucomatous Visual Field Defects and Loss of Nerve Fiber Layer Thickness Measured with Polarimetry and Spectral Domain OCT

Horn

Mardin

Laemmer

et al. 2009

Invest. Ophthalmol. Vis. Sci.

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“…An integer EOC score ranging from 0 (where the regression is non-significant, p.0.1) to 5 (where the regression is highly significant, p,0.002) is given to each sector. Similarly, the optic disc was divided into four sectors corresponding to the visual field (inferior, superior, nasal, and temporal, respectively 15 ). The sectoral optic disc EOC score was derived in an identical manner to that of the visual field based on the regression of sectoral neuroretinal rim area over follow up time.…”

Section: Discussionmentioning

confidence: 99%

Central corneal thickness and progression of the visual field and optic disc in glaucoma

Chauhan

2005

British Journal of Ophthalmology

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Aims: To determine whether central corneal thickness (CCT) is a significant predictor of visual field and optic disc progression in open angle glaucoma. Methods: Data were obtained from a prospective study of glaucoma patients tested with static automated perimetry and confocal scanning laser tomography every 6 months. Progression was determined using a trend based approach called evidence of change (EOC) analysis in which sectoral ordinal scores based on the significance of regression coefficients of visual field pattern deviation and neuroretinal rim area over time are summed. Visual field progression was also determined using the event based glaucoma change probability (GCP) analysis using both total and pattern deviation. Results: The sample contained 101 eyes of 54 patients (mean (SD) age 56.5 (9.8) years) with a mean follow up of 9.2 (0.7) years and 20.7 (2.3) sets of examinations every 6 months. Lower CCT was associated with worse baseline visual fields and lower mean IOP in the follow up. In the longitudinal analysis CCT was not correlated with the EOC scores for visual field or optic disc change. In the GCP analyses, there was a tendency for groups classified as progressing to have lower CCT compared to nonprogressing groups. In a multivariate analyses accounting for IOP, the opposite was found, whereby higher CCT was associated with visual field progression. None of the independent factors were predictive of optic disc progression. Conclusions: In this cohort of patients with established glaucoma, CCT was not a useful index in the risk assessment of visual field and optic disc progression.

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Quantitative analysis of visual field and optic disk in glaucoma: retinal nerve fiber bundle-associated analysis

Cited by 10 publications

References 34 publications

The relationship between structure and function as measured by OCT and Octopus perimetry

The relationship between structure and function as measured by OCT and Octopus perimetry

Correlation between Local Glaucomatous Visual Field Defects and Loss of Nerve Fiber Layer Thickness Measured with Polarimetry and Spectral Domain OCT

Central corneal thickness and progression of the visual field and optic disc in glaucoma

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