The relationship between structure and function as measured by OCT and Octopus perimetry

Abstract

Background/aims To determine the structurefunction relationship between equivalent visual field areas obtained with the Octopus perimeter (OP), and the peripapillary retinal nerve fibre layer (RNFL) thickness measured with spectral-domain optical coherence tomography (OCT) in healthy individuals and patients with glaucomatous optic neuropathy. Methods Eighty-eight normal subjects and 150 patients with open-angle glaucoma were prospectively recruited. Eligible participants for the glaucoma group were required to have elevated intraocular pressure and glaucomatous optic nerve head morphology. All participants underwent reliable automated perimetry with OP, and optic nerve head imaging with the Cirrus OCT. Principal component analysis of the mean threshold values for the visual field test points were performed independently for each hemifield. Pearson correlations were calculated between visual field regions and RNFL thickness sectors. Results Mild to moderate correlations were observed between the visual field regions and the peripapillary RNFL thicknesses. Each visual field region was significantly correlated with more than one RNFL sector, and vice versa. The strongest correlation was observed between the RNFL thickness at 5 and 7 clock-hour positions and the superonasal region of OP (r=0.63). Conclusions Retinal sensitivity evaluated with OP correlated moderately well with the RNFL thickness measured by OCT. There was an overlap of the visual field regions within the optic disc.

Comparison between the Correlations of Retinal Nerve Fiber Layer Thickness Measured by Spectral Domain Optical Coherence Tomography and Visual Field Defects in Standard Automated White-on-White Perimetry versus Pulsar Perimetry

“…This makes it easier to group functionally related test points into clusters and to couple these visual field clusters to defined areas of the ONH [ 12 , 17 ]. In a recent study, Monsalve et al [ 18 ] presented a structure-function map using OCT sectors and Octopus VF regions obtained completely from objective analysis of healthy participants and patients with glaucoma. This map shows reasonable agreement with that of Garway-Heath et al [ 15 , 18 ].…”

“…In a recent study, Monsalve et al [ 18 ] presented a structure-function map using OCT sectors and Octopus VF regions obtained completely from objective analysis of healthy participants and patients with glaucoma. This map shows reasonable agreement with that of Garway-Heath et al [ 15 , 18 ].…”

Comparison of structure–function relationship between corresponding retinal nerve fibre layer thickness and Octopus visual field cluster defect values determined by normal and tendency-oriented strategies

“…In contrast, the fast and easily performed TOP strategy has been widely used 2–6 13–15 22. However, due to its special algorithm, the threshold sensitivity values (and the parameters calculated from them) are influenced by the responses given at the neighbouring points, which modifies the final results 1 2 16.…”

Prevalence of Unknown Ocular Hypertension, Glaucoma Suspects, and Glaucoma in Patients Seen in an Ophthalmology Center in France

“…Uncomplicated ocular hypertension was defined as ocular hypertension without any criteria for glaucoma suspect or glaucoma. Glaucoma was defined as the association of a glaucomatous papilla (see criteria in Table 1) and a confirmed visual field defect on 2 successive tests, regardless of the IOP [8,11,12]. Other criteria for diagnosis of glaucoma according to the International Society for Geographical and Epidemiological Ophthalmology (ISGEO) classification were used for a sensitivity analysis ( Table 1) [13].…”