Comparison of structure–function relationship between corresponding retinal nerve fibre layer thickness and Octopus visual field cluster defect values determined by normal and tendency-oriented strategies

Abstract

Octopus normal and TOP strategies provide similar, moderate-to-strong negative correlation between the corresponding cluster defect and sector RNFLT values for all 10 manufacturer-provided clusters. For corrected clusters the relationship is poor, which suggests that by correcting for diffuse sensitivity loss some local glaucomatous defect is removed. For structure-function based clinical decisions, use of TOP is possible but use of corrected clusters is not recommended.

Relationship between optical coherence tomography sector peripapillary angioflow-density and Octopus visual field cluster mean defect values

“…In the current investigation we evaluated the relationship between global, inferotemporal and superotemporal peripapillary PAFD, a non-invasive OCT angiography parameter of peripapillary perfusion of the RPC layer, and the spatially corresponding global and cluster Octopus visual field MD values, respectively, in a population comprising healthy, medically controlled OHT and predominantly mild-to-moderate primary open-angle glaucoma eyes. Global MD and the 10 cluster MDs are those Octopus visual field parameters offered by the EyeSuite software for the G test which have been widely used for glaucoma severity classification, glaucoma diagnostics and follow-up in clinical practice [ 22 , 23 ]. In addition, to establish the relationship between the corresponding sector PAFD and cluster MD values for those sector—cluster pairs which have been established in our earlier study for sector RNFLT and are available with the PAFD analysis software version used by us [ 14 , 15 , 23 ] we also compared the strength of the relationship between the corresponding sector RNFLT and sector PAFD, and the spatially corresponding visual field cluster MD.…”

“…In the current investigation the RNFLT values provided for the total circle (total peripapillary RNFLT) and 2 of the 16 22.5°-sized sector RNFLT values (the inferotemporal and the superotemporal RNFLT, Fig 1 ) were used. The RNFLT sectors were determined based on anatomical considerations using the instrument-provided 16 RNFLT sectors [ 23 , 26 ].…”

“…Only reproducible tests with less than 20% false positive and 20% false negative response rates were used for evaluation. The manufacturer-provided 10 visual field clusters [ 23 ] were used ( Fig 1 ). The clusters of the left eyes were mirrored and numbered as those of right eyes.…”

“…In glaucoma structural damage is often localized in early to moderate disease stages. Recently we have shown strong positive relationship between narrow sector RNFLT and Octopus visual field cluster sensitivity values [ 22 ], and moderate-to-strong negative relationship between 10 sector RNFLT values and the corresponding 10 Octopus visual field cluster mean defect (cluster MD) values [ 23 ]. We found a particularly strong relationship between inferotemporal RNFLT and the corresponding superotemporal cluster MD [ 23 ].…”

“…Recently we have shown strong positive relationship between narrow sector RNFLT and Octopus visual field cluster sensitivity values [ 22 ], and moderate-to-strong negative relationship between 10 sector RNFLT values and the corresponding 10 Octopus visual field cluster mean defect (cluster MD) values [ 23 ]. We found a particularly strong relationship between inferotemporal RNFLT and the corresponding superotemporal cluster MD [ 23 ]. In the current investigation we evaluated the relationship between sector PAFD and Octopus visual field cluster MD values for those sector—cluster pairs which have been established in our previous investigations and are available with the software version used by us (the inferotemporal sector—superotemporal cluster pair; and the superotemporal sector—inferotemporal cluster pair, Fig 1 ).…”