Correlation between Local Glaucomatous Visual Field Defects and Loss of Nerve Fiber Layer Thickness Measured with Polarimetry and Spectral Domain OCT

Horn, Folkert K.; Mardin, Christian Y.; Laemmer, Robert; Baleanu, D.; Juenemann, Anselm; Kruse, Friedrich E.; Tornow, Ralf P.

doi:10.1167/iovs.08-2405

Cited by 84 publications

(74 citation statements)

References 39 publications

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“…3 In this model, the measured RNFL thickness is T M (T M ¼ T A0 Â 10 À D/10 þ T R ). [3][4][5] In this formula, T A0 is the RNFL thickness attributable to the RGC axons in the healthy normal state, D is the VF defect value (dB), and T R is the residual or base thickness, including glial cells and blood vessels. In normal eyes (assuming D ¼ 0), T M consists of two components: T A0 (normal RGC axon thickness) and T R (base thickness).…”

Section: Discussionmentioning

confidence: 99%

“…T R was determined for each sector as the median of the RNFL thickness when localized VF losses were 4 À 10 dB; because when field losses are worse than À 10 dB, the RNFL thickness reaches an asymptotic value according to the function formula (T M ¼ T A0 Â 10 À D/10 þ T R) . 3,5 T A0 is the RNFL thickness attributable to the RGC axons in the healthy normal state and was calculated by assuming D ¼ 0. T M in normal subjects was the average RNFL thickness of age-matched control subjects for each sector.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4][5][6]12,14,[16][17][18] However, most of these studies used the Stratus time Correlation of localized glaucomatous VF defects and SD-OCT RNFL thinning H Wu et al domain OCT to measure RNFL thickness. [2][3][4]6,13,14,16,17 Although in two of these studies, SD-OCT was used to evaluated RNFL thickness, 5,18 the structure-function correspondence maps made in those studies correlated VF test points to regions of the ONH.…”

Section: Discussionmentioning

confidence: 99%

“…Significant correlations have been described between glaucomatous structural changes of the optic disc and/or retinal nerve fiber layer (RNFL) and functional changes on VF testing. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Determining whether there is good correlation between localized VF defects and localized RNFL defects may be important in deciding whether glaucomatous progression has occurred and in understanding the pathogenesis of the disease.…”

Section: Introductionmentioning

confidence: 99%

“…12 Because previous studies have suggested that structurefunction associations are stronger with OCT measurements compared with the other two technologies, 5,12 the current study used the Spectralis spectral domain OCT (SD-OCT) (Heidelberg Engineering, Inc., Heidelberg, Germany) for RNFL thickness structural assessments. This paper, in particular, focuses on the topographic association between specific areas of glaucomatous VF loss and specific locations in the course of the RNFL bundles, and this topographic association can be delineated by structure-function correspondence maps.…”

Section: Introductionmentioning

confidence: 99%

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Correlation of localized glaucomatous visual field defects and spectral domain optical coherence tomography retinal nerve fiber layer thinning using a modified structure–function map for OCT

Boer

Chen

et al. 2015

Eye

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Purpose To study the correlation between glaucomatous visual field (VF) defects assessed by standard automated perimetry (SAP) and peripapillary retinal nerve fiber layer (RNFL) thinning measured by spectral domain optical coherence tomography (OCT) using a modified OCT-based peripapillary RNFL structure-function map. Patients and methods Perimetric glaucoma patients and age-matched normal control subjects were recruited from a university hospital clinic. All eyes underwent testing with the Spectralis spectral domain OCT and SAP on the same day. An OCT-based correspondence map, which correlated VF areas with peripapillary RNFL sectors was created to evaluate the relationship between glaucomatous RNFL thinning and VF loss in six nerve fiber layer bundle areas. Correlations of RNFL thinning with corresponding VF defects were examined using Spearman rankorder correlations. To demonstrate the association between localized VF defects and RNFL thickness, the theoretical curves were made according to an established log-linear model. The measured RNFL thickness values and VF defects were presented in the same scatterplot for each sector. Results Fifty-six glaucoma patients and 85 normal subjects were included in the study.Significant association between localized VF loss and RNFL thinning was found in corresponding areas. Data from the current study fit well with established log-linear models, which compare RNFL thickness values with VF defects. Conclusion Analysis of RNFL thinning in eyes with localized glaucomatous VF defects showed good structure-function correlation in a new OCT-based structure-function correspondence map.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Correlation of localized glaucomatous visual field defects and spectral domain optical coherence tomography retinal nerve fiber layer thinning using a modified structure–function map for OCT

Boer

Chen

et al. 2015

Eye

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Structure-Function Relationship in Glaucoma Using Spectral-Domain Optical Coherence Tomography

Rao¹,

Zangwill²,

Weinreb³

et al. 2011

Arch Ophthalmol

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Relationship Between Fuchs Endothelial Corneal Dystrophy Severity and Glaucoma and/or Ocular Hypertension

et al. 2012

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Objective To investigate if Fuchs' Endothelial Corneal Dystrophy (FECD) severity is associated with glaucoma and/or ocular hypertension (G/OHTN). Methods A subset of eyes (n=1610) from the FECD Genetics Multi-Center Study were examined to estimate the association between FECD severity (grades 0–6 based on guttae confluence) and G/OHTN. Logistic regression models were fit that accounted for the correlation between eyes and adjusted for age, sex, central corneal thickness, intraocular pressure, presence of diabetes, and time of day of initial evaluation. Results 107 eyes (6.6%) had G/OHTN based on the study definition. The prevalence of G/OHTN in the control group was 6%. Prevalence was lower in index cases with an FECD grade of 1 through 3 and family members with a grade of 0 or 1 through 3 (0% and 2%, respectively) but higher in index cases and family members with a grade of 4 through 6 (11% and 9%, respectively). Adjusting for covariates, eyes with a grade of 4 through 6 were more likely to have concurrent G/OHTN than eyes with no FECD (index cases vs. controls: OR=2.10, p=0.04; affected vs. unaffected family: OR=7.06, p=0.07). Age (OR=1.06 per 1 year increase, p<0.001) and intraocular pressure (OR=1.15 per 1 mmHg increase, p<0.001) were also associated with an increased prevalence of G/OHTN. Sex, diabetes, time of day of evaluation, and central corneal thickness were not associated with the prevalence of G/OHTN (p>0.15). Conclusions Glaucoma and/or ocular hypertension occurs more often in eyes affected with severe FECD compared to unaffected eyes. Therefore, it may be beneficial to monitor for the development of glaucoma in these patients.

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Correlation between Local Glaucomatous Visual Field Defects and Loss of Nerve Fiber Layer Thickness Measured with Polarimetry and Spectral Domain OCT

Cited by 84 publications

References 39 publications

Correlation of localized glaucomatous visual field defects and spectral domain optical coherence tomography retinal nerve fiber layer thinning using a modified structure–function map for OCT

Correlation of localized glaucomatous visual field defects and spectral domain optical coherence tomography retinal nerve fiber layer thinning using a modified structure–function map for OCT

Structure-Function Relationship in Glaucoma Using Spectral-Domain Optical Coherence Tomography

Relationship Between Fuchs Endothelial Corneal Dystrophy Severity and Glaucoma and/or Ocular Hypertension

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