Quantifying the DNA-damaging Effects of FLASH Irradiation With Plasmid DNA

Abstract

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Technical note: Characterization and practical applications of a novel plastic scintillator for online dosimetry for an ultrahigh dose rate (FLASH)

“…The plastic scintillator was used in tandem with a Gafchromic EBT-XD film to measure the transmission dose in two FLASH-RT experiments-plasmid DNA detectors, 39,41 and cell plates that consisted either of Zebrafish embryos in well-type cell plates or conventional cell cultures in petri dishes. The results are shown in Figure 6.…”

Comparison of intratumor and local immune response between MV X-ray FLASH and conventional radiotherapies

“…This unique biological response drives research enthusiasm in the clinical applications of FLASH-RT [10] , [13] . Although the underlying mechanisms of the FLASH effect are unclear, attempts are ongoing to define the involved affecting factors and [3] , [14] , [15] , identify the triggering conditions of the FLASH effect to take advantage of the unique radiobiological response [8] , [16] , and enlarge the therapeutic window by incorporating other therapy techniques [17] .…”

Radical Production with Pulsed Beams: Understanding the Transition to FLASH

“…Recent experiments seem to support the radical recombination hypothesis [ 33 ]. A reduction in the yield of H 2 O 2 has been observed under FLASH irradiation in water [ 15 , 34 ].…”